A study on nitroimidazole-99mTc(CO)3 complexes as hypoxia marker: some observations towards possible improvement in in vivo efficacy [0.03%]
硝基咪唑-99mTc(CO)3配合物作为低氧示踪剂的研究：关于体内有效性的改进方法的初步探索
Madhava B Mallia,Suresh Subramanian,Anupam Mathur et al.
Madhava B Mallia et al.
Introduction: Hypoxia plays a negative role in the clinical management of cancer. Detection of hypoxic status of a cancer is important for selecting patients for hypoxia directed therapy. Though [(18)F]fluoromisonidazole ...
Human whole-body biodistribution and dosimetry of a new PET tracer, [(11)C]ketoprofen methyl ester, for imagings of neuroinflammation [0.03%]
新的PET示踪剂((11)C]氟化甲基酮洛芬的全身生物分布及剂量学研究在神经炎症分子显像中的应用
Akihito Ohnishi,Michio Senda,Tomohiko Yamane et al.
Akihito Ohnishi et al.
Introduction: Neuroinflammatory processes play an important role in the pathogenesis of Alzheimer's disease and other brain disorders, and nonsteroidal anti-inflammatory drugs (NSAIDs) are considered therapeutic candidate...
Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability [0.03%]
人动脉粥样硬化斑块基质金属蛋白酶基因表达水平及放射性标记抑制剂显像剂评价
Adrienne Müller,Stefanie D Krämer,Romana Meletta et al.
Adrienne Müller et al.
Introduction: Atherosclerotic plaque rupture is the primary cause for myocardial infarction and stroke. During plaque progression macrophages and mast cells secrete matrix-degrading proteolytic enzymes, such as matrix met...
Comparison of trans-1-amino-3-[18F]fluorocyclobutanecarboxylic acid (anti-[18F]FACBC) accumulation in lymph node prostate cancer metastasis and lymphadenitis in rats [0.03%]
反式-1-氨基-3-[18F]氟环丁烷甲酸（反-[18F]FACBC）在前列腺癌淋巴结转移瘤与炎性淋巴结大鼠模型中的摄取比较研究
Masaru Kanagawa,Yoshihiro Doi,Shuntaro Oka et al.
Masaru Kanagawa et al.
Introduction: Trans-1-amino-3-[(18)F]fluorocyclobutanecarboxylic acid (anti-[(18)F]FACBC) is a positron emission tomography (PET) tracer used to visualize prostate cancer (PCa). In this study, we investigated the differen...
Comparative Study
Nuclear medicine and biology. 2014 Aug;41(7):545-51. DOI:10.1016/j.nucmedbio.2014.04.004 2014
Kit formulated asialoglycoprotein receptor targeting tracer based on copolymer for liver SPECT imaging [0.03%]
基于共聚物的以天冬酰胺苷凝集素受体为靶点的放射性药物肝显像研究
Chang Liu,Zhide Guo,Pu Zhang et al.
Chang Liu et al.
Introduction: Specific targeting of galactose-carrying molecule to ASGP-R in normal hepatocytes has been demonstrated before. In this study, galactosyl polystyrene was synthesized from controllable ratio of functional mon...
Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors [0.03%]
克龄蒙对绝经后妇女血管舒缩症状影响的随机、双盲、安慰剂平行对照的多中心临床试验
Nicholas J Lodge,Yu-Wen Li,Frederick T Chin et al.
Nicholas J Lodge et al.
Introduction: A radioligand for measuring the density of corticotropin-releasing factor subtype-1 receptors (CRF1 receptors) in living animal and human brain with positron emission tomography (PET) would be a useful tool ...
PEG spacers of different length influence the biological profile of bombesin-based radiolabeled antagonists [0.03%]
不同长度的聚乙二醇Spacer对抗体炸弹肽类似物的生物分布的影响
Mazen Jamous,Maria L Tamma,Eleni Gourni et al.
Mazen Jamous et al.
Introduction: The gastrin-releasing peptide receptor (GRPR) was shown to be expressed with high density on several types of cancers. Radiolabeled peptides for imaging and targeted radionuclide therapy have been developed....
Radiolabeling and in vitro evaluation of (67)Ga-NOTA-modular nanotransporter--a potential Auger electron emitting EGFR-targeted radiotherapeutic [0.03%]
新型放射性核素标记的纳米载体及其体外评价研究：一种潜在的抗EGFR靶向治疗新方法
Eftychia Koumarianou,Tatiana A Slastnikova,Marek Pruszynski et al.
Eftychia Koumarianou et al.
Introduction: Modular nanotransporters (MNTs) are vehicles designed to transport drugs from the cell surface via receptor-mediated endocytosis and endosomal escape to nucleus. Hence their conjugation to Auger electron emi...
Synthesis and evaluation of (18)F-labeled bile acid compound: a potential PET imaging agent for FXR-related diseases [0.03%]
一种FXR相关疾病正电子显像剂的合成与评价
Lina Jia,Dawei Jiang,Pengcheng Hu et al.
Lina Jia et al.
The farnesoid-X-receptor (FXR) is a member of the nuclear hormone receptor superfamily. The FXR has critical functions in maintaining bile acid synthesis and homeostasis, liver regeneration and tumorigenesis, intestinal diseases, intestinal...
Development and preclinical evaluation of new (124)I-folate conjugates for PET imaging of folate receptor-positive tumors [0.03%]
新型(I-124)-叶酸偶联物的开发及临床前评估用于叶酸受体阳性肿瘤PET显像
I AlJammaz,B Al-Otaibi,F Al-Rumayan et al.
I AlJammaz et al.
In an attempt to develop new folate radiotracers with favorable biochemical properties for detecting folate receptor-positive cancers, we have synthesized [(124)I]-SIB- and [(124)I]-SIP-folate conjugates using a straightforward and two-step...