Prognostic value of 3'-deoxy-3'-18F-fluorothymidine ([(18)F] FLT PET) in patients with recurrent malignant gliomas [0.03%]
复发性恶性胶质瘤患者3'-脱氧-3'-(18F)氟胸腺嘧啶((18F)FLT正电子发射断层扫描(PET))的预后价值
Fen Zhao,Yunfeng Cui,Minghuan Li et al.
Fen Zhao et al.
Introduction: 3'-deoxy-3'-18F-fluorothymidine ([(18)F] FLT) PET has been proven to be of value in diagnosis and assessment of glioma grading, in differentiating tumor recurrence from necrosis, in response assessment and i...
Photo-production of (99)Mo/(99m)Tc with electron linear accelerator beam [0.03%]
电子直线加速器光子活化生产钼-99/ technetium-99m
R Avagyan,A Avetisyan,I Kerobyan et al.
R Avagyan et al.
We report on the development of a relatively new method for the production of (99)Mo/(99m)Tc. The method involves the irradiation of natural molybdenum using high-intensity bremsstrahlung photons from the electron beam of the LUE50 linear e...
Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[(11)C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors [0.03%]
标记碳-11的N-(((5-(4-氟-2-(碳-11甲基)-6-氟苯基)吡啶-3-基)甲基)环戊烷胺)作为PET示踪剂用于含有NR2B亚单位的NMDA受体的合成与临床前评价
Johannes A M Christiaans,Pieter J Klein,Athanasios Metaxas et al.
Johannes A M Christiaans et al.
Introduction: The N-methyl-D-Aspartate (NMDA) receptor plays an important role in learning and memory. Overactivation is thought to play an important role in neurodegenerative disorders such as Alzheimer's disease. Curren...
Dopamine D(2)/D(3) receptor binding of [(123)I]epidepride in risperidone-treatment chronic MK-801-induced rat schizophrenia model using nanoSPECT/CT neuroimaging [0.03%]
纳米SPECT/CT神经影像在利培酮治疗慢性MK-801诱导的大鼠精神分裂模型中检测[(123)I]epidepride对D(2)/D(3)受体的亲和力
Y R Huang,C W Pai,K H Cheng et al.
Y R Huang et al.
Introduction: Epidepride is a compound with an affinity in picomolar range for D2/D3 receptors. The aim of this work was designed to investigate the diagnostic possibility of [(123)I]epidepride imaging platform for risper...
Jurgen Seidel,Marcelino L Bernardo,Karen J Wong et al.
Jurgen Seidel et al.
Introduction: We describe and illustrate a method for creating ECG-gated PET images of the heart for each of several mice imaged at the same time. The method is intended to increase "throughput" in PET research studies of...
Assessment of the best N(3-) donors in preparation of [M(N)(PNP)]-based (M=(99m)Tc-; (188)Re) target-specific radiopharmaceuticals: Comparison among succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG600-DTCZ) [0.03%]
评估[N(3-)]配体(SDH, HDTCZ和HO2C-PEG600-DTCZ)在制备[M(N)(PNP)](-)(M=(99m)Tc,-,(188)Re)靶向放射性药物中的作用：SDH，N-甲基-S-甲基二硫卡巴肼(HDTCZ)和PEG修饰的N-甲基-S-甲基二硫卡巴肼(HO2C-PEG600-DTCZ)之间的比较
Davide Carta,Christian Jentschel,Stefan Thieme et al.
Davide Carta et al.
Succinic dihydrazide (SDH), N-methyl-S-methyl dithiocarbazate (HDTCZ) and PEGylated N-methyl-S-methyl dithiocarbazate (HO2C-PEG600-DTCZ) are nitrido nitrogen atom donors employed for the preparation of nitride [M(N)]-complexes (M=(99m)Tc an...
Comparative Study
Nuclear medicine and biology. 2014 Aug;41(7):570-81. DOI:10.1016/j.nucmedbio.2014.04.126 2014
(11)C-Labeling of a potent hydroxyethylamine BACE-1 inhibitor and evaluation in vitro and in vivo [0.03%]
用于标记一种有效的羟乙胺BACE-1抑制剂的(11)C及其体内外评价
Patrik Nordeman,Sergio Estrada,Luke R Odell et al.
Patrik Nordeman et al.
Introduction: The enzyme β-secretase 1 (BACE-1) is associated with the catalytic cleavage of amyloid precursor protein (APP) which leads to the production of amyloid-β, an amyloidogenic peptide that forms insoluble fibr...
A radiometabolite study of the serotonin transporter PET radioligand [(11)C]MADAM [0.03%]
一种新的五羟色胺转运体PET配体(11C)MADAM的放射性代谢物研究
F Gourand,P Emond,J P Bergström et al.
F Gourand et al.
Introduction: (11)C]MADAM is a radioligand suitable for PET studies of the serotonin transporter (SERT). Metabolite analysis in human and non-human plasma samples using HPLC separation has shown that [(11)C]MADAM was rapi...
Pre-clinical evaluation of [(68)Ga]Ga-DO3A-VS-Cys(40)-Exendin-4 for imaging of insulinoma [0.03%]
一种新型放射性标记GLP-1类似物 exendin-4的体内评价及其在胰岛素瘤显像中的应用研究
Ram Kumar Selvaraju,Irina Velikyan,Veronika Asplund et al.
Ram Kumar Selvaraju et al.
Introduction: Insulinoma is the most common form of pancreatic endocrine tumors responsible for hyperinsulinism in adults. These tumors overexpress glucagon like peptide-1 (GLP-1) receptor, and biologically stable GLP-1 a...