Radiochemistry of cyclen-derived chelators comprising five-membered azaheterocyclic arms with 212Pb2+, 213Bi3+, and 225Ac3 [0.03%]
含有五个氮杂环臂的cyclen衍生物螯合物与212Pb2+、213Bi3+和225Ac3+的放射化学研究
Ina Hierlmeier,Parmissa Randhawa,Brooke L McNeil et al.
Ina Hierlmeier et al.
In this work, we introduce the cyclen-based metal chelator DOTThia comprising four methylthiazole arms for metal complexation. Together with the recently described congener DOTI-Me bearing four methylimidazole arms, the radiochemistry of th...
Synthesis and evaluation of a 99mTc-labelled deuterated tropane derivative as a SPECT probe for dopamine transporter [0.03%]
一种新的99mTc标记的氘代生物碱衍生物作为合成代谢型单胺转运体SPECT显像剂的研究
Jing Kang,Jingwen Li,Chunyi Liu et al.
Jing Kang et al.
Introduction: The dopamine transporter (DAT) is intricately associated with a broad spectrum of neurological disorders including Parkinson's disease and various other neurodegenerative conditions. In vivo imaging DAT with...
Dmitry Filosofov,Ayagoz Baimukhanova,Jurabek Khushvaktov et al.
Dmitry Filosofov et al.
Targeted Alpha Therapy (TAT) holds significant promise as a localized treatment for cancer. Encouraging clinical results from using peptides and antibodies labeled with alpha emitters to treat patients with metastatic cancers, particularly ...
Carbon-11-labelling of the histone deacetylase 6 radioligand EKZ-001 [0.03%]
一种用于标记HDAC6放射配体EKZ-001的碳-11方法
Tetsuro Tago,Jun Toyohara
Tetsuro Tago
Purpose: Histone deacetylase 6 (HDAC6) is involved in microtubule stabilisation and protein degradation, and is attracting attention as a therapeutic target molecule for neurodegenerative diseases. [18F]EKZ-001 is a posit...
Enhancing the therapeutic index of [211At]YF2 with iodo pseudo carrier: A simple strategy for reducing accumulation in kidneys, salivary and lacrimal glands [0.03%]
用碘伪载体增强[YF₂]²¹₁At的治疗指数：一种减少肾脏、唾液腺和泪腺蓄积的简单策略
Truc T Huynh,Yutian Feng,Rebecca L Banks et al.
Truc T Huynh et al.
Introduction: Low-molecular-weight (LMW) PSMA-targeted agents have enjoyed success; however, their off-target toxicity in normal tissues such as kidneys, salivary gland and lacrimal gland can be dose limiting. Herein, we ...
Evaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [18F]SynVesT-1 metabolism analysis in rats [0.03%]
评价放射薄层色谱作为放射HPLC的小鼠[18F]SynVesT-1代谢分析的替代方法
Tutukhanim Balayeva,Ruth H Asch,Peng Wen Tan et al.
Tutukhanim Balayeva et al.
Purpose: Alterations in synaptic vesicle glycoprotein 2A (SV2A) are linked to various neurodegenerative and neuropsychiatric disorders. Positron emission tomography (PET) imaging with radiotracers targeting SV2A, such as ...
Biodistribution and long-term toxicity of neutron-activated Samarium-153 oxide-loaded polystyrene microspheres in healthy rats [0.03%]
健康大鼠体内~(153)Sm中毒理学效应及长期毒性研究
Hun Yee Tan,Yin How Wong,Azahari Kasbollah et al.
Hun Yee Tan et al.
Purpose: Selective internal radiation therapy (SIRT) is an effective, minimally invasive treatment for intermediate and advanced-stage liver malignancies, particularly when other curative options are not viable. As an alt...
Adaptation of a commercially available module for the production of alpha-[11C]methyl-L-tryptophan ([11C]AMT) for human use [0.03%]
一种用于生产正电子发射断层扫描(PET)示踪剂alpha-［11C］甲基左旋色氨酸(［11C］AMT)的商业化模块的人用改造及验证研究
Karsten Bamminger,Cécile Philippe,Natalie Schindler et al.
Karsten Bamminger et al.
The complex radiosynthesis of alpha-[11C]methyl-L-tryptophan ([11C]AMT) involves harsh chemicals and conditions, posing challenges for its implementation on commercially available synthesis modules. This study describes the adaptation of th...
Application of [99mTc]Tc-GSA in the diagnosis of Staphylococcus aureus infections [0.03%]
应用于金黄色葡萄球菌感染诊断的[99mTc]Tc-GSA
Asuka Mizutani,Ami Kondo,Yuka Muranaka et al.
Asuka Mizutani et al.
Introduction: Staphylococcus aureus can cause a variety of conditions such as bacteremia, sepsis, toxic shock syndrome, pneumonia, and infective endocarditis; therefore, a rapid and accurate diagnosis should be made to pi...
Nicotinic acetylcholine receptor imaging with [18F]ASEM for skeletal muscle denervation: A novel assessment for peripheral neuromuscular disorders [0.03%]
用于骨骼肌失神经的[18F]ASEM烟碱型乙酰胆碱受体显像：外周神经肌肉病的一种新评估方法
Jae Sung Park,Jin Hwa Jung,Seog-Young Kim et al.
Jae Sung Park et al.
Purpose: Despite its invasive and subjective nature, needle electromyography (nEMG) remains a standard method for evaluating peripheral nerve injuries. Increased alpha-7 nicotinic acetylcholine receptor (alpha7-nAChR) exp...