Optimization and scale-up of [68Ga]Ga-FAPI-46 production on a Modular-Lab PharmTracer platform for clinical application [0.03%]
在模块化实验室PharmTracer平台上优化和放大[68Ga]Ga-FAPI-46的生产以供临床应用
Irene Brusa,Veronica Serena Cabitza,Stefano Emiliani et al.
Irene Brusa et al.
Background: Due to the increasing application of the fibroblast activation protein (FAP) targeting radiotracer [68Ga]Ga-FAPI-46 in cancer diagnostics by PET/CT, there is a need for a convenient way for routine production ...
Investigating the fate of Zirconium-89 labelled antibody in cynomolgus macaques [0.03%]
研究恒河猴体内89锆标记抗体的命运
Takanori Sasaki,Sadaaki Kimura,Akihiro Noda et al.
Takanori Sasaki et al.
Background: Preclinical pharmacokinetic studies of therapeutic antibodies in non-human primates are desired because of the difficulty in extrapolating ADME data from animal models to humans. We evaluated the pharmacokinet...
Terbium-161 in nuclear medicine: Preclinical and clinical progress in comparison with lutetium-177 [0.03%]
核医学中的铽-161：与镥-177相比的临床前和临床进展
František Trejtnar,Pavel Bárta,Ján Kozempel et al.
František Trejtnar et al.
The use of new radiopharmaceuticals labeled with lutetium-177 represents a successful translation of experimental results into clinical practice. Recent experimental data suggests that terbium-161 might well follow the example of lutetium-1...
Longitudinal multi-tracer imaging of hepatocellular carcinoma identifies novel stage- and oncogene-specific changes [0.03%]
肝细胞癌的纵向多示踪剂成像可识别新型分期及致癌基因特异性变化
Mari Teuter,Yuhai Hu,Tobias L Ross et al.
Mari Teuter et al.
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, globally. There is a need for novel biomarkers for early detection and novel, effective targeted therapies. Molecular imaging can fai...
Radiolabeling yield dependency of post-dry distillation decay of astatine-211 [0.03%]
砹-211干燥蒸馏后放射性标记产量的衰变依赖性
Ellinor Hansson,Chiara Timperanza,Holger Jensen et al.
Ellinor Hansson et al.
Aim/introduction: Astatine-211 (211At) is one of the most promising nuclides for targeted alpha therapy. However, while several clinical trials are ongoing worldwide, some aspects of the element remain unexplored. This wo...
Quantitative imaging using [18F]F-TZ3108 to assess metabolic-associated fatty liver disease progression and low-carbohydrate diet efficacy [0.03%]
使用[18F]F-TZ3108定量成像评估代谢相关性脂肪性肝病进展和低碳水化合物饮食疗效
Zongping Han,Min Yang,Lei Bi et al.
Zongping Han et al.
Objective: The Sigma-1 receptor (Sig-1R), located in the mitochondrion-associated membranes (MAMs), is an important biomarker for endoplasmic reticulum (ER) stress and plays a crucial role in the advancement of metabolic-...
First-in-human healthy volunteer dosimetry studies of the excitatory amino acid transporter 2 (EAAT2) PET imaging tracer methyl N4-(7-[18F]fluoro-9H-fluoren-2-yl)asparaginate, [18F]RP-115 [0.03%]
人首次放射性新药甲基N4-（7-[-18F]氟-9H-荧烯-2-基）天冬氨酰的健康志愿者首例剂量学研究：用于兴奋性氨基酸转运体2（EAAT2）PET显影剂
Chih-Kai Chao,Joseph Blecha,Ilona Polvoy et al.
Chih-Kai Chao et al.
Objective and background: The objective of this first-in-human study was to investigate the radiosynthesis, and the preliminary safety, biodistribution, and organ radiation dosimetry of the positron emission tomography (P...
Production and purification of radiolabeling-ready 132/135La from the irradiation of metallic natBa targets with low energy protons [0.03%]
低能质子辐照天然钡靶生产并提纯用于放射性标记的132/135La同位素
E S Kurakina,B L McNeil,J Khushvaktov et al.
E S Kurakina et al.
Introduction: Radiolanthanides 132La and 135La form a promising chemically matched theranostic pair. With a half-life of 18.95 h, 135La acts as the therapeutic isotope as it releases approximately 11 Auger electrons per d...
[18F]BCPP-EF positron emission tomography of rat ovaries for evaluation of mitochondrial function [0.03%]
用于评估线粒体功能的大鼠卵巢正电子发射断层扫描([18F]BCPP-EF)
Yuki Tomonari,Hiroyuki Ohba,Hideo Tsukada
Yuki Tomonari
Background: The ovary is an important female organ not only for pregnancy but also for the regulation of life activities via hormone release. Ovarian function is measured by blood hormone levels, but the hormone level ref...
Cross sections of the 226Ra(p,xn) reactions relevant for 225Ac production [0.03%]
有关于225Ac产生的226Ra（p，xn）反应的部分截面
Ondřej Lebeda,Kateřina Ondrák Fialová,Lukáš Ondrák et al.
Ondřej Lebeda et al.
Limited availability constrains the implementation of 225Ac, the most promising α emitter for targeted therapy, in clinical practice. Proton activation of 226Ra is one of few realistic solutions to this problem. We have therefore measured ...