Adaptation of a commercially available module for the production of alpha-[11C]methyl-L-tryptophan ([11C]AMT) for human use [0.03%]
一种用于生产正电子发射断层扫描(PET)示踪剂alpha-［11C］甲基左旋色氨酸(［11C］AMT)的商业化模块的人用改造及验证研究
Karsten Bamminger,Cécile Philippe,Natalie Schindler et al.
Karsten Bamminger et al.
The complex radiosynthesis of alpha-[11C]methyl-L-tryptophan ([11C]AMT) involves harsh chemicals and conditions, posing challenges for its implementation on commercially available synthesis modules. This study describes the adaptation of th...
Application of [99mTc]Tc-GSA in the diagnosis of Staphylococcus aureus infections [0.03%]
应用于金黄色葡萄球菌感染诊断的[99mTc]Tc-GSA
Asuka Mizutani,Ami Kondo,Yuka Muranaka et al.
Asuka Mizutani et al.
Introduction: Staphylococcus aureus can cause a variety of conditions such as bacteremia, sepsis, toxic shock syndrome, pneumonia, and infective endocarditis; therefore, a rapid and accurate diagnosis should be made to pi...
Nicotinic acetylcholine receptor imaging with [18F]ASEM for skeletal muscle denervation: A novel assessment for peripheral neuromuscular disorders [0.03%]
用于骨骼肌失神经的[18F]ASEM烟碱型乙酰胆碱受体显像：外周神经肌肉病的一种新评估方法
Jae Sung Park,Jin Hwa Jung,Seog-Young Kim et al.
Jae Sung Park et al.
Purpose: Despite its invasive and subjective nature, needle electromyography (nEMG) remains a standard method for evaluating peripheral nerve injuries. Increased alpha-7 nicotinic acetylcholine receptor (alpha7-nAChR) exp...
Novel dibutyl ether resin for the purification of the Auger emitter antimony-119 from tin targets [0.03%]
一种新型二丁基醚树脂用于从锡靶中纯化砹-119（Auger电子发射体）
Aivija Grundmane,Caterina F Ramogida,Valery Radchenko
Aivija Grundmane
Antimony-119 (119Sb, t1/2 = 38.19 h) is an Auger electron emitting radionuclide of interest for radiopharmaceutical therapy (RPT). The potential of 119Sb has only been explored theoretically, due to the absence of a suitable bifunctional ch...
Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy [0.03%]
用于分子放射治疗的CD44v6靶向抗体的亲和力成熟和优化
Anja Charlotte Lundgren Mortensen,Camilla Hofström,Helena Persson et al.
Anja Charlotte Lundgren Mortensen et al.
Aim: This study aimed to improve the efficacy of the CD44v6-targeting antibody UU-40 for molecular radiotherapy through affinity maturation and IgG subclass optimization. M&M: A panel of affinity-matured antibody candidat...
Biodistribution of [18F]BCPP-BF in humans: a first-in-human positron emission tomography study [0.03%]
[18F]BCPP-BF在人体内的生物分布：一项首次在人类中的正电子发射断层扫描研究
Kengo Sato,Tomoyasu Bunai,Akinori Oda et al.
Kengo Sato et al.
Introduction: [18F]BCPP-BF and [18F]BCPP-EF are PET probes used to evaluate mitochondrial function by targeting MC-I. Clinical studies on [18F]BCPP-EF have been reported, particularly brain studies. However, no reports ex...
Verena Pichler,Matthias Manfred Herth,Verena Hugenberg et al.
Verena Pichler et al.
The rapid growth of radiopharmaceutical sciences, driven by regulatory approvals of theranostic agents and the expanding role of PET imaging, underscores the need for sustainable and green practices. While radiopharmaceuticals offer high pr...
Radiation dosimetry of the 18 kDa translocator protein ligand [18F]PBR111 in humans [0.03%]
人受试者[18F]PBR111放射剂量学研究(18kDa转运蛋白配体)
Benjamin B Tournier,Zahra Mansouri,Yazdan Salimi et al.
Benjamin B Tournier et al.
Purpose: The 18 kDa translocator protein (TSPO) is a mitochondrial protein that becomes overexpressed during neuroinflammatory conditions, such as in Alzheimer's disease or multiple sclerosis. TSPO is of interest because ...
Corrigendum to "Alpha Atlas: Mapping global production of α-emitting radionuclides for targeted alpha therapy" [Nucl Med Biol (March-April 2025) 108990] [0.03%]
勘误表：“Alpha Atlas：全球生产用于靶向α疗法的α发射放射性核素的地图”[Nucl Med Biol (2025年3-4月) 108990]
Marianna Tosato,Chiara Favaretto,Janke Kleynhans et al.
Marianna Tosato et al.
IAEA activities to support the member states in the production of targeted alpha therapy radiopharmaceuticals [0.03%]
国际原子能机构支持成员国生产靶向阿尔法治疗放射性药物的活动
A R Jalilian,J Kleynhans,P Bouziotis et al.
A R Jalilian et al.
Due to the growing interest of International Atomic Energy Agency (IAEA) Member States in implementing targeted radionuclide therapy (TRT) in general, the demand for alpha-emitting radionuclides and radiopharmaceuticals is enormous. As an i...