Corticolimbic activation patterns during aversive audiogenic stress assessed by cerebral perfusion using [99mTc]HMPAO SPECT/CT [0.03%]
使用[99mTc]HMPAO SPECT/CT评估听觉应激期间的脑血流模式以观察皮层边缘系统的激活模式
Angel Moldes-Anaya,Lorenzo Ragazzi,Torgil R Vanberg et al.
Angel Moldes-Anaya et al.
Background: Emotional experiences modulate behavior by influencing the central and peripheral nervous systems, playing a crucial role in the pathophysiology of neuropsychiatric disorders. This study investigates the neura...
Preclinical evaluation and dosimetry of [64Cu/67Cu]Cu-NGUL for PSMA-targeted prostate cancer theranostics [0.03%]
铜-64/67铜-NGUL用于PSMA靶向前列腺癌诊疗的药代学研究与剂量学研究
Hye Yeon Seo,Minseok Suh,Nadeem Ahmed Lodhi et al.
Hye Yeon Seo et al.
Background: Prostate-specific membrane antigen (PSMA) is a promising target for imaging and theranostics in prostate cancer (PCa). Current PSMA tracers face limitations due to short half-lives and logistics. We developed ...
Targeted alpha therapy of ovarian cancer with 212Pb-labeled anti-PTK7 antibody: On-site 212Pb production and preclinical insights [0.03%]
用于卵巢癌治疗的212Pb标记抗PTK7抗体靶向α疗法：现场212Pb生产及前期研究发现
Yani Berckmans,Roxanne Wouters,Zeljka Raskovic-Lovre et al.
Yani Berckmans et al.
Background: Targeted alpha therapy (TAT) is recognized as a promising approach for eradicating tumor micro-metastases, owing to its high linear energy transfer. These micro-metastases are often associated with elevated re...
Illuminating radionuclide therapy response: Monitoring cancer cell and CAF survival in a direct 2D co-culture model [0.03%]
放射核素治疗反应的检测：直接二维共培养模型中癌细胞和CAF存活情况的监测
Circe D van der Heide,Roisin McMorrow,Felipe Gama-Franceschi et al.
Circe D van der Heide et al.
Background: Targeted radionuclide therapy (TRT) directed at fibroblast activation protein (FAP), highly expressed on cancer-associated fibroblasts (CAFs), is a promising approach for treating stroma-rich tumors such as pa...
Evaluation of an 211At-labeled RGD peptide in an orthotopic glioblastoma model by targeted alpha therapy [0.03%]
评价211At标记的RGD肽在原位胶质母细胞瘤模型中的靶向α治疗效应
Hiroaki Echigo,Masayuki Munekane,Takeshi Fuchigami et al.
Hiroaki Echigo et al.
Introduction: Glioblastoma, the most aggressive and malignant glioma type, remains challenging to treat, necessitating novel therapeutic strategies. Building on our previous development of an 211At-labeled RGD peptide, Ga...
Evaluation of astatine-211-labeled benzoate derivatives for improved in vivo stability [0.03%]
评估苯甲酸衍生物的砹-211标记以提高其体内稳定性
Mutsuho Murata,Kento Kannaka,Souta Tatsuta et al.
Mutsuho Murata et al.
Purpose: Astatine-211 (211At) is one of the most promising α-particle-emitting radionuclides used for targeted-alpha therapy. Benzene derivatives are currently commonly used as 211At-labeling moieties for preparing 211At...
Alternative production of Lead-203: Optimizing production, purification, and radiolabelling for enhanced theranostic applications [0.03%]
铅-203的替代生产：优化生产、纯化和放射性标记以增强诊疗应用
Nadia Audouin,Héloïse Dufour,Aurélien Vidal et al.
Nadia Audouin et al.
Introduction: this study investigates the production of Lead-203 (203Pb) using a deuteron beam and demonstrates its application with DOTATATE for diagnostic imaging of neuroendocrine tumours (NETs) thanks to its γ-ray em...
Johannes Ermert,Stephen Moerlein
Johannes Ermert
Ravi Naik,Hyojin Cha,Fangyi Shen et al.
Ravi Naik et al.
Background: Positron-emission tomography (PET) imaging of the complement system could advance understanding of the innate immune system in central nervous system (CNS) diseases and development of new drugs. The goal of th...
L-5-[11C]-glutamine PET of breast cancer: Preclinical studies in mouse models [0.03%]
L-5-[11C]谷氨酰胺乳腺癌小鼠模型的正电子发射断层扫描研究
Christopher T Hensley,Prashanth Padakanti,Raheema Damani et al.
Christopher T Hensley et al.
Background: Glutamine is an important metabolic substrate in many aggressive tumors, with comparable importance to glucose metabolism. Utilizing human breast cancer mouse xenograft models, we studied the kinetics of the P...