PET evaluation of cholinergic system differences in progressive supranuclear palsy and age-matched controls using [18F]VAT [0.03%]
使用[18F]VAT对进行性核上性麻痹和年龄匹配对照组胆碱能系统差异的正电子发射断层扫描评估
Ying-Hwey Nai,John L O&#x;Donnell,Aaron Tanenbaum et al.
Ying-Hwey Nai et al.
Background: The availability of binding sites for the vesicular acetylcholine transporter (VAChT) provides a measure of presynaptic cholinergic neuron terminals, which undergo degeneration in various conditions, including...
Scandium-47 as a radionuclide precursor: Feasibility of production in a 47Ca/47Sc generator-like system [0.03%]
47Sc作为放射性核素前体的可行性研究：在47Ca/47Sc发生器系统中生产的影响因素分析
Izabela Cieszykowska,Małgorzata Żółtowska,Dariusz Pawlak et al.
Izabela Cieszykowska et al.
Background: Scandium-47 (47Sc), a medium-energy β- emitter with a half-life of 3.35 days and associated γ emission (159 keV, 68.1 %), is an attractive radionuclide for targeted radionuclide therapy and theranostics. Pro...
PET imaging of [64Cu]copper(II) chloride and tetrathiomolybdate administration in animal models of triple-negative breast cancer [0.03%]
三阴性乳腺癌动物模型中[64Cu]氯化铜(II)和四硫钼酸盐的正电子发射断层成像(PET)
Michael R Lewis,Claudia G Chambers,Maryam Heidari-Kharaji et al.
Michael R Lewis et al.
Background: In the United States, breast cancer is the second leading cause of cancer-related death. Triple-negative breast cancer (TNBC) is of substantial concern, as it lacks the receptors usually targeted by convention...
Matched pair suitability of 89Zr and 177Lu-labeled L804-LLP2A theranostics for targeting VLA-4 in melanoma [0.03%]
89Zr和177Lu标记的L804-LLP2A配对用于黑色素瘤VLA-4靶向诊疗的匹配性研究
Cyril O Y Fong,Ejike V Iweha,Fabio Gallazzi et al.
Cyril O Y Fong et al.
There is a need for chelators that are versatile for complexing multiple radiometals. We previously demonstrated that the macrocyclic 1,2-HOPO chelator, L804, has utility for complexing 177Lu(III) for radiopharmaceutical therapy and 89Zr(IV...
Development of glycoside-based nuclear medicine imaging agents for the sodium-glucose co-transporters in cancer cells [0.03%]
基于糖苷的核医学影像剂的发展用于癌细胞中的钠葡萄糖同向转运蛋白
Kakeru Sato,Ririka Handa,Jianwei Yao et al.
Kakeru Sato et al.
Introduction: Sodium-glucose co-transporters (SGLTs), particularly SGLT1 and SGLT2, play an active role in glucose uptake by cancer cells and have gained attention as novel therapeutic targets. However, the development of...
Integrating [11C]methylreboxetine PET and MRI to map in vivo norepinephrine transporter distribution: A proof-of-concept study of noradrenergic vulnerability in neurodegeneration [0.03%]
整合[11C]甲基雷波西汀PET和MRI以在体绘制去甲肾上腺素转运蛋白分布：神经变性中交感神经系统脆弱性的概念验证研究
Jaime D Mondragon,Sofia Marcolini,Bruno Lima Giacobbo et al.
Jaime D Mondragon et al.
Background: The locus coeruleus (LC) and its noradrenergic projections are among the earliest sites displaying pathology in Alzheimer's disease (AD) and Parkinson's disease (PD). In vivo measures of norepinephrine transpo...
Recovery of zinc-68 from gallium-68 cyclotron target effluent: A method to establish wet chemistry capabilities for metal precursor recovery in PET radiometals [0.03%]
从Ga-68回旋加速器靶废液中回收Zn-68：建立PET放射金属前体湿法化学回收能力的方法
Ian M Horn,Anna C Bitzer,Patrick L Day et al.
Ian M Horn et al.
Background: Gallium-68 (68Ga) is a PET isotope that is finding more use in the clinical setting as a PET diagnostic tool, e.g. 68Ga PSMA is widely used in the diagnosis of prostate cancer, and 68Ga dotatate for the diagno...
Estimation of the binding potential of the PET ligand [18F]FEDAC to translocator protein 18 kDa (TSPO) in the brain of experimental stroke model rats [0.03%]
估算实验性脑卒大鼠模型大脑中正电子发射断层显影配体[18F]FE-DAM与18kD转位蛋白的结合率
Tomoteru Yamasaki,Yiding Zhang,Wakana Mori et al.
Tomoteru Yamasaki et al.
Purpose: Translocator protein 18 kDa (TSPO) is a biomarker for neuroinflammation, and [18F]FEDAC was developed as a clinically usable radioligand for its imaging. Here, quantitative PET analyses of [18F]FEDAC in the brain...
Recent advances in understanding and improving the stability of 211At-radiopharmaceuticals [0.03%]
近期关于211At放射性药物稳定性的研究进展与改进措施
Romain Fouinneteau,Nicolas Galland,Cécile Perrio et al.
Romain Fouinneteau et al.
Astatine-211 is more than ever a serious candidate radionuclide to achieve success of targeted alpha therapy of cancers in the close future. However, several challenges remain to be overcome in order to guarantee the translation of 211At-la...
Radiolabelling bacteria with 89Zr-DBN for PET/MRI: comparing [89Zr]Zr oxalate and [89Zr]Zr phosphate [0.03%]
放射性标记细菌进行正电子发射断层扫描/磁共振成像(PET/MRI)：89Zr-DBN的草酸盐与磷酸盐比较研究
Diksha,Sarah C Donnelly,Mojmir Suchy et al.
Diksha et al.
Purpose: Our bodies host a diverse and complex community of bacteria, known as the microbiota, which play a crucial role in overall wellness. The gut microbiota perform essential functions, such as food fermentation, path...