Johannes Ermert,Stephen Moerlein
Johannes Ermert
Ravi Naik,Hyojin Cha,Fangyi Shen et al.
Ravi Naik et al.
Background: Positron-emission tomography (PET) imaging of the complement system could advance understanding of the innate immune system in central nervous system (CNS) diseases and development of new drugs. The goal of th...
L-5-[11C]-glutamine PET of breast cancer: Preclinical studies in mouse models [0.03%]
L-5-[11C]谷氨酰胺乳腺癌小鼠模型的正电子发射断层扫描研究
Christopher T Hensley,Prashanth Padakanti,Raheema Damani et al.
Christopher T Hensley et al.
Background: Glutamine is an important metabolic substrate in many aggressive tumors, with comparable importance to glucose metabolism. Utilizing human breast cancer mouse xenograft models, we studied the kinetics of the P...
[18F]FDG-PET provides insights into the liver-brain axis and confirms SUVgluc as a surrogate for MRGlu in a mouse model of liver fibrosis [0.03%]
[18F] FDG-PET 揭示肝脑轴并证实SUVgluc可作为肝纤维病鼠模型中MRGlu的替代指标
Thomas Wanek,Mari Teuter,Asha Balakrishnan et al.
Thomas Wanek et al.
Purpose: The liver-brain axis regulates metabolic homeostasis, with glucose metabolism playing a key role. Liver dysfunction, such as fibrosis, may impact brain metabolism and consequently, brain function. Positron emissi...
Shayla Shmuel,Lin Qiu,Alex Vanover et al.
Shayla Shmuel et al.
Human Epidermal Growth Factor Receptor 2 (HER2) is a membrane receptor tyrosine kinase overexpressed in a subset of gastric cancers and is the target of multiple clinically approved therapies, including the antibody-drug conjugate trastuzum...
Characterization of [11C]DASB and [18F]FE-PE2I using microPET imaging in SERT and DAT knockout rats [0.03%]
微PET成像在中枢单胺转运体基因敲除大鼠中的应用研究
Cyprien G J Guerrin,Debbie R M Tesselaar,Emile E Zweistra et al.
Cyprien G J Guerrin et al.
Rationale: [11C]DASB is widely used for PET imaging of brain serotonin transporters (SERT) and the tropane ligand [18F]FE-PE2I is used for PET imaging of dopamine transporters (DAT). However, their in vivo selectivity has...
PET imaging of the cannabinoid receptor 2 ligand 4-O-[11C]methylhonokiol in a rat glioma model [0.03%]
放射性碳-11标记的甲基红葵碱正电子发射断层成像术在胶质瘤模型中对大麻素受体2配体的作用
Jia-Zhe Lin,Maria Kominia,Janine Doorduin et al.
Jia-Zhe Lin et al.
Purpose: Several studies have suggested that the neolignan 4-O-methylhonokiol has antitumor activity. The aim of this study was to investigate the distribution, kinetics and tumor accumulation of this potential antitumor ...
Predictive tumor dosimetry and pharmacokinetic evaluation of [67Cu]Cu-rhPSMA-10.1 and [68Ga]Ga-rhPSMA-10.1 with PET/SPECT MRI in an orthotopic mouse model of glioblastoma [0.03%]
在正交鼠脑胶质母细胞瘤模型中，用PET / SPECT MRI预测[67Cu]Cu-rhPSMA-10.1和[68Ga]Ga-rhPSMA-10.1的肿瘤剂量学和药代动力学
Thomas Kolle Ekaney,Ursula Søndergaard,Rodrigo Berzaghi et al.
Thomas Kolle Ekaney et al.
Targeted radionuclide therapy (TRT) is an emerging pillar of precision medicine, with prostate-specific membrane antigen (PSMA)-targeted agents like [177Lu]PSMA-617 demonstrating notable clinical success. Achieving optimal therapeutic effic...
Myocardial kinetics of [11C]β-hydroxybutyrate in healthy pigs: Comparison of positron emission tomography imaging vs. arteriovenous balance methods [0.03%]
健康猪的心肌[11C]β-羟丁酸动力学：正电子发射断层显像与动静脉平衡法的比较
Mette Louise Gram Kjærulff,Mie Ringgaard Dollerup,Aage Kristian Olsen Alstrup et al.
Mette Louise Gram Kjærulff et al.
Background: Accurate assessment of myocardial ketone uptake and oxidation is essential for understanding cardiac metabolism. This study aims to validate positron emission tomography (PET) imaging as a non-invasive method ...
ImmunoPET for mesothelin positive tissues using bio-orthogonal in-vivo click chemistry [0.03%]
基于生物正交点击化学的间皮素阳性组织免疫PET研究
Edwin C Pratt,Komal Mandleywala,David Bauer et al.
Edwin C Pratt et al.
Mesothelin is a membrane bound antigen overexpressed in a wide array of cancers including ovarian, pancreatic, lung, and triple negative breast cancers. Here a full-length IgG antibody developed against mesothelin, called MESO-HSS1 was conj...