NMB Innovators Series Professor Dae Yoon Chi, Ph.D.: Understanding of 18F-chemistry and its applications toward drug developments used in diagnosis and therapeutics [0.03%]
NMB创新者系列Chi大云教授博士:氟-18化学研究及其在药物开发中的应用：诊断和治疗
Hee Seup Kil,Byung Chul Lee,Dong Wook Kim et al.
Hee Seup Kil et al.
Hongchao Zhang,Olof Eriksson,Matts Olovsson et al.
Hongchao Zhang et al.
Introduction: Endometriosis, affecting up to 10% of women, is a chronic estrogen dependent disorder where ectopic endometrial-like tissue causes pelvic pain and infertility. Endometriosis is challenging to diagnose due to...
Enhanced tumor retention of the novel LAT1-targeting PET probe [18F]FAMT-OMe: A comparative study with [18F]FAMT in glioma mouse models [0.03%]
新型LAT1靶向PET探针[18F]FAMT-OMe在肿瘤中的滞留增强：与[18F]FAMT在胶质瘤小鼠模型中的比较研究
Thosapol Sampunta,Tadashi Watabe,Sadahiro Naka et al.
Thosapol Sampunta et al.
Introduction: [18F]fluoro-L-α-methyltyrosine ([18F]FAMT) has been reported as a positron-emission tomography (PET) probe that has high specificity for L-type amino acid transporter 1 (LAT1), which is overexpressed in var...
Automated cassette-based synthesis, metabolism, and dosimetry of [18F]ApaScan, a PET tracer for aldosterone synthase imaging [0.03%]
自动化的卡式盒基于合成、代谢及[18F]ApaScan剂量学PET追踪物成像醛固酮合成酶影像研究
Yuki Shimizu,Toko Otaka,Miho Shidahara et al.
Yuki Shimizu et al.
Introduction: Aldosterone-producing adenomas (APAs) account for most cases of primary aldosteronism (PA), a major cause of secondary hypertension and hypokalemia. Although adrenal vein sampling (AVS) is the diagnostic gol...
Development of a new 18F-labeled PET tracer for potential application to HDAC2 neuroimaging [0.03%]
一种新的用于组蛋白去乙酰酶2神经影像潜在应用的氟-18标记正电子发射断层显像剂的研发
Yafei Huang,Yongle Wang,Yanli Wang et al.
Yafei Huang et al.
Histone deacetylases (HDACs) play an important role in the regulation of cellular functions and have attracted highly attention as promising therapeutic targets for the treatment of neurodegenerative diseases. Among the various HDAC isoform...
Sharon L Samuel,Solana Fernandez,Shelbie J Cingoranelli et al.
Sharon L Samuel et al.
Objective: This study aims to characterize and compare the saturation limits, spatial resolution, and image quality of various conventional and emerging positron-emitting radionuclides using a preclinical PET/CT scanner. ...
Nektarios Pirmettis,Alexandros Pappas,Sevban Doğan Ekici et al.
Nektarios Pirmettis et al.
Azeotropic removal of water remains a significant limitation in fluorine-18 radiochemistry, often leading to longer synthesis times, variable yields, increased solvent use and operational complexity, and, indirectly, increased resource dema...
Post-column derivatization high-performance liquid chromatography-ultraviolet-ultraviolet (HPLC-UV) method for the detection of Kryptofix 2.2.2 content in Positron Emission Tomography (PET) tracers [0.03%]
柱后衍生化高效液相色谱-双紫外检测法测定正电子发射断层扫描(PET)示踪剂中Kryptofix 2.2.2含量的方法研究
Lei Xu,Zhenhao Dong,Hong Zhang et al.
Lei Xu et al.
A post-column derivatization high-performance liquid chromatography-ultraviolet (HPLC-UV) method was developed to determine Kryptofix 2.2.2 (K2.2.2) in PET tracers. This method utilizes the specific complexation between K2.2.2 and Pb2+, for...
Takako Furukawa,Yasuhisa Fujibayashi,Charles Metzger
Takako Furukawa