C-H (radio)fluorination of hydroxamides via strained and electronically tunable α-lactams enabled by N-O scission [0.03%]
通过N=O键断裂实现的环张力及电子可调α- lactam介导的羟胺酸的C-H/(Radio)氟化反应
Siran Qian,Surendra Reddy Gundam,Carol Garcia et al.
Siran Qian et al.
Positron emission tomography (PET) fluorine-18 radiosynthesis primarily relies on operationally robust, albeit scope-limited methodologies. Therefore, a marked scientific need remains for new PET-compatible labelling protocols to expand rad...
Kinetic modelling and evaluation of the TrkA/B/C radioligand [18F]TRACK in the pig brain [0.03%]
标记追踪在猪脑中的动力学模型及评估研究
Cassis Varlow,Clara A Madsen,Carolin Jaworski et al.
Cassis Varlow et al.
Tropomyosin receptor kinase B (TrkB) is a critical mediator of neuronal growth, survival, and synaptic plasticity, which is activated by the endogenous ligand, brain-derived neurotrophic factor (BDNF). TrkB has been implicated in a wide ran...
Rodent biodistribution and dosimetry of the PET radioligands [18F]CHDI-385 and [18F]CHDI-386 targeting mutant huntingtin aggregates [0.03%]
针对突变亨廷顿蛋白聚集体的正电子发射断层扫描放射配体[18F]CHDI-385和[18F]CHDI-386在啮齿类动物中的生物分布与剂量学研究
Jordy Akkermans,Alan Miranda,Jeroen Verhaeghe et al.
Jordy Akkermans et al.
Background: Huntington's disease is a neurodegenerative condition resulting from an expanded CAG repeat in the huntingtin gene that produces a mutant form of the huntingtin protein (mHTT). In this study we estimated the r...
PET evaluation of cholinergic system differences in progressive supranuclear palsy and age-matched controls using [18F]VAT [0.03%]
使用[18F]VAT对进行性核上性麻痹和年龄匹配对照组胆碱能系统差异的正电子发射断层扫描评估
Ying-Hwey Nai,John L O&#x;Donnell,Aaron Tanenbaum et al.
Ying-Hwey Nai et al.
Background: The availability of binding sites for the vesicular acetylcholine transporter (VAChT) provides a measure of presynaptic cholinergic neuron terminals, which undergo degeneration in various conditions, including...
Scandium-47 as a radionuclide precursor: Feasibility of production in a 47Ca/47Sc generator-like system [0.03%]
47Sc作为放射性核素前体的可行性研究：在47Ca/47Sc发生器系统中生产的影响因素分析
Izabela Cieszykowska,Małgorzata Żółtowska,Dariusz Pawlak et al.
Izabela Cieszykowska et al.
Background: Scandium-47 (47Sc), a medium-energy β- emitter with a half-life of 3.35 days and associated γ emission (159 keV, 68.1 %), is an attractive radionuclide for targeted radionuclide therapy and theranostics. Pro...
PET imaging of [64Cu]copper(II) chloride and tetrathiomolybdate administration in animal models of triple-negative breast cancer [0.03%]
三阴性乳腺癌动物模型中[64Cu]氯化铜(II)和四硫钼酸盐的正电子发射断层成像(PET)
Michael R Lewis,Claudia G Chambers,Maryam Heidari-Kharaji et al.
Michael R Lewis et al.
Background: In the United States, breast cancer is the second leading cause of cancer-related death. Triple-negative breast cancer (TNBC) is of substantial concern, as it lacks the receptors usually targeted by convention...
Matched pair suitability of 89Zr and 177Lu-labeled L804-LLP2A theranostics for targeting VLA-4 in melanoma [0.03%]
89Zr和177Lu标记的L804-LLP2A配对用于黑色素瘤VLA-4靶向诊疗的匹配性研究
Cyril O Y Fong,Ejike V Iweha,Fabio Gallazzi et al.
Cyril O Y Fong et al.
There is a need for chelators that are versatile for complexing multiple radiometals. We previously demonstrated that the macrocyclic 1,2-HOPO chelator, L804, has utility for complexing 177Lu(III) for radiopharmaceutical therapy and 89Zr(IV...
Development of glycoside-based nuclear medicine imaging agents for the sodium-glucose co-transporters in cancer cells [0.03%]
基于糖苷的核医学影像剂的发展用于癌细胞中的钠葡萄糖同向转运蛋白
Kakeru Sato,Ririka Handa,Jianwei Yao et al.
Kakeru Sato et al.
Introduction: Sodium-glucose co-transporters (SGLTs), particularly SGLT1 and SGLT2, play an active role in glucose uptake by cancer cells and have gained attention as novel therapeutic targets. However, the development of...
Integrating [11C]methylreboxetine PET and MRI to map in vivo norepinephrine transporter distribution: A proof-of-concept study of noradrenergic vulnerability in neurodegeneration [0.03%]
整合[11C]甲基雷波西汀PET和MRI以在体绘制去甲肾上腺素转运蛋白分布：神经变性中交感神经系统脆弱性的概念验证研究
Jaime D Mondragon,Sofia Marcolini,Bruno Lima Giacobbo et al.
Jaime D Mondragon et al.
Background: The locus coeruleus (LC) and its noradrenergic projections are among the earliest sites displaying pathology in Alzheimer's disease (AD) and Parkinson's disease (PD). In vivo measures of norepinephrine transpo...
Recovery of zinc-68 from gallium-68 cyclotron target effluent: A method to establish wet chemistry capabilities for metal precursor recovery in PET radiometals [0.03%]
从Ga-68回旋加速器靶废液中回收Zn-68：建立PET放射金属前体湿法化学回收能力的方法
Ian M Horn,Anna C Bitzer,Patrick L Day et al.
Ian M Horn et al.
Background: Gallium-68 (68Ga) is a PET isotope that is finding more use in the clinical setting as a PET diagnostic tool, e.g. 68Ga PSMA is widely used in the diagnosis of prostate cancer, and 68Ga dotatate for the diagno...