Evaluating the tumour detection efficacy of [18F]Fluorthanatrace positron emission tomography in a metastatic lung cancer animal model [0.03%]
评价[18F]fluothanatrace正电子发射断层扫描在转移性肺癌动物模型中检测肿瘤的有效性
Chi-Chang Weng,Che-Hsing Chu,Faria Khan et al.
Chi-Chang Weng et al.
Lung cancer is a leading cause of cancer-related mortality worldwide, with high metastatic potential and limited imaging tools for guiding targeted therapies. Poly(ADP-ribose) polymerase (PARP)-1 is overexpressed in multiple malignancies an...
Development of a pyrogallol-formaldehyde resin column for one-step pre-purification of 68Ge/68Ga generator eluates: Enhanced [68Ga]Ga-DOTA-TATE radiolabeling yield by selective removal of tetravalent cationic impurities [0.03%]
一种用于一步预纯化68Ge/68Ga发生器洗脱液的焦棓鞣酸-甲醛树胶柱的开发：通过选择性去除四价阳离子杂质提高[68Ga]Ga-DOTA-TATE放射标记产率
Fatemeh Ebrahimi,Zahra Ghiamaty,Sara Roustaei et al.
Fatemeh Ebrahimi et al.
A pyrogallol-formaldehyde resin (PGR) column was developed for one-step pre-purification of 68Ge/68Ga generator eluates. The resin selectively adsorbs tetravalent cations (Ge4+, Sn4+, Ti4+) with efficiencies of 81.8%, 42.4%, and 29.8% in st...
[68Ga]Ga-NOTA-ATH001 positron emission tomography as a general tool for non-invasive detection of platelet derived growth factor receptor beta in mesenchymal cells [0.03%]
[68Ga]Ga-NOTA-ATH001正电子发射断层显像用于非侵入性检测间充质细胞血小板衍生生长因子受体-beta
Bogdan Mitran,Olof Eriksson
Bogdan Mitran
Introduction: Platelet-derived growth factor receptor beta (PDGFRβ) is a widely used and important marker for mesenchymal cells, including fibroblasts, vascular smooth muscle cells, and pericytes. Dysfunction of the mese...
NMB innovators Series Professor Olof Solin: Bridging the gap between the targetry and clinical diagnostics [0.03%]
NMB创新者系列：奥洛夫·索林教授：连接靶向和临床诊断之间的桥梁
Anna K Kirjavainen,Sarita Forsback,Anu J Airaksinen
Anna K Kirjavainen
Biodistribution of 161Tb- or 177Lu-labeled immunoconjugate in comparison with its potential metallic radioactive degradation products and contaminants [0.03%]
161Tb或177Lu标记的免疫缀合物与其潜在的金属放射性降解产物和污染物的竞争分布研究
Pavel Bárta,Nikta Mehdizadeh,Marie Skálová et al.
Pavel Bárta et al.
Radionuclides emitting beta- particles and Auger electrons present real or perspective radioactive components of radiopharmaceuticals used or developed for radionuclide therapy. Two important representatives of such radionuclides, lutetium-...
Importance of an alkyl group inserted into the DOTA backbone for reducing renal radioactivity levels of 111In-labeled antibody fragments [0.03%]
Dota骨架中插入的烷基基团对降低抗体重链抗体片段的肾脏放射性水平的重要性研究
Hiroyuki Suzuki,Kento Ichinohe,Mari Araki et al.
Hiroyuki Suzuki et al.
Introduction: 1,4,7,10-Tetrazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a promising chelator for radiotheranostic applications. Recently, we developed a DOTA-based radiolabeled antibody fragment, [111In]In-DO3AiBu...
Comparative biological evaluation of [18F]fluciclovine, [18F]FBPA-Fr, and [18F]FET for boron neutron capture therapy: Preclinical validation and clinical feasibility [0.03%]
[18F]氟氯氨酸、[18F]FBPA-Fr和[18F]FET用于硼中子俘获治疗的生物对比评估： preclinical验证与临床可行性
Ting-Yu Chang,Ko-Han Lin,Tzu-Yu Lee et al.
Ting-Yu Chang et al.
Purpose: The PET tracer 4‑borono-2-[18F]-fluoro-phenylalanine fructose ([18F]FBPA-Fr) is commonly used to estimate the biodistribution of L-4-dihydroxy-borylphenylalanine fructose (BPA-Fr). However, its limited regulator...
Preclinical characterization of a novel FAP-targeted PET tracer, [68Ga]Ga-CB6NT-FAPI [0.03%]
新型FAP靶向PET示踪剂[68Ga]Ga-CB6NT-FAPI的临床前特征化研究
Hye Yeon Seo,Hwa Sil Kim,Ran Ji Yoo et al.
Hye Yeon Seo et al.
Fibroblast activation protein (FAP) is an established target for molecular imaging of the tumor stroma. In this study, we report the development and preclinical evaluation of a novel FAP-targeted positron emission tomography (PET) tracer, [...
Development of angiostatin based radiopharmaceutical as a sensitive tool for detection of ATP synthase during acute vascular damage [0.03%]
基于angiostatin的放射性药物的发展作为检测急性血管损伤期间ATP合成酶的敏感工具
Ankon Das,Tikum Florence,Carolina Rego Rodrigues et al.
Ankon Das et al.
Background: Angiostatin (ANG) is an endogenously cleaved protein of the plasminogen-plasmin conversion pathway which is activated during tumor angiogenesis and oxidative stress. One of the hallmarks of sub-clinical oxidat...
Development of a novel xCT transporter imaging using a radiopharmaceutical with inhibitor-type compounds [0.03%]
开发一种使用放射性药物和抑制类型化合物的新型xCT转运蛋白成像技术
Kakeru Sato,Jundai Yamagagta,Yuka Hirayama et al.
Kakeru Sato et al.
Background: The cystine/glutamate antiporter xCT has attracted attention due to its role in maintaining redox homeostasis. Noninvasive techniques for visualizing xCT expression in tumors provide valuable diagnostic inform...