Nektarios Pirmettis,Alexandros Pappas,Sevban Doğan Ekici et al.
Nektarios Pirmettis et al.
Azeotropic removal of water remains a significant limitation in fluorine-18 radiochemistry, often leading to longer synthesis times, variable yields, increased solvent use and operational complexity, and, indirectly, increased resource dema...
Post-column derivatization high-performance liquid chromatography-ultraviolet-ultraviolet (HPLC-UV) method for the detection of Kryptofix 2.2.2 content in Positron Emission Tomography (PET) tracers [0.03%]
柱后衍生化高效液相色谱-双紫外检测法测定正电子发射断层扫描(PET)示踪剂中Kryptofix 2.2.2含量的方法研究
Lei Xu,Zhenhao Dong,Hong Zhang et al.
Lei Xu et al.
A post-column derivatization high-performance liquid chromatography-ultraviolet (HPLC-UV) method was developed to determine Kryptofix 2.2.2 (K2.2.2) in PET tracers. This method utilizes the specific complexation between K2.2.2 and Pb2+, for...
Takako Furukawa,Yasuhisa Fujibayashi,Charles Metzger
Takako Furukawa
Spontaneous association of different forms of non-conjugated astatine-211 to serum albumin [0.03%]
不同形式的非偶联砹-211与血清白蛋白的自发结合
Emma Aneheim,Sture Lindegren,Holger Jensen et al.
Emma Aneheim et al.
Aim/introduction: Astatine-211 is one of the alpha-particle emitting nuclides investigated for use within Targeted Alpha Therapy (TAT) of disseminated cancer. In previous studies, a difference in blood clearance has been ...
Mesothelin-targeted alpha therapy in PDAC with [225Ac]Ac-Macropa-PEG6-Amatuximab [0.03%]
锕-225标记的Macropa-amatuximab靶向治疗人源PDAC异种移植模型中的间皮素阳性肿瘤
Syed Qaiser Shah,Ralph Santos-Oliveira,Madeeha Shabnam et al.
Syed Qaiser Shah et al.
Pancreatic ductal adenocarcinoma (PDAC) continues to be deadly and resistant to traditional treatments. Overexpressed in >80% of PDACs, mesothelin is an ideal target for antibody-based α-therapy. Actinium-225 (225Ac) produces high-LET α-p...
Implemented one-pot two step fully automated synthesis of [18F]FPIA for metabolic imaging applications [0.03%]
用于代谢成像应用的[18F]FPIA一键两步全自动合成法的成功实现
José S Enriquez,Vincenzo Paolillo,Ryan Armijo et al.
José S Enriquez et al.
Background: [18F]Fluoropivalate ([18F]FPIA), also known as 18F-pivalate or 18F-RAD101, is the fluorinated analogue of pivalic acid and has shown promise in ongoing clinical trials for the detection of brain metastases. Th...
Development of an automated one-step radiolabeling procedure for a PSMA-targeted radiotherapeutic for prostate cancer [0.03%]
前列腺癌PSMA放射治疗药物的自动一步法放射标记程序的研发
Meltem Ocak,Kanishka Sikligar,Michael Pun et al.
Meltem Ocak et al.
Background: CTT1403 (177Lu-CTT2001), an irreversible phosphoramidate PSMA inhibitor developed by Cancer Targeted Technology, was initially synthesized using a two-step radiolabeling method and has previously been evaluate...
H3RESCA chelator-enabled [18F]AlF labeling: An optimized temperature-resilient platform for PSMA-targeted PET tracers in prostate cancer [0.03%]
H3RESCA配体导向的[18F]AlF标记：前列腺癌PSMA靶向PET示踪剂的优化和耐温性平台
Yukai Zhang,Zhoumi Hu,Qingyu Zhang et al.
Yukai Zhang et al.
Objective: Prostate-specific membrane antigen (PSMA) has emerged as a pivotal biomarker for the molecular imaging and targeted therapy of prostate cancer. To address the ongoing need for PSMA-targeting radiotracers with i...
In vitro evaluation of anti-HIV radioimmunoconjugates labeled with astatine-211, thorium-227 and actinium-225 [0.03%]
211At、227Th和225Ac标记的抗HIV放射免疫结合物的体外评价研究
Anne-Sophie Kuhlmann,Donald K Hamlin,Yawen Li et al.
Anne-Sophie Kuhlmann et al.
We conducted an in vitro investigation of the selective cytotoxicity of alpha-emitting radioimmunoconjugates (α-RICs) directed against cells expressing HIV envelope (Env) proteins. It is well known that monoclonal antibody (mAb)-targeted ...
Substitution matters: Comparison of four N,1,4-tri(methoxy-2-hydroxybenzyl)-DAZA ligands as potential PET/CT liver imaging agents [0.03%]
N,1,4-三(甲氧基-2-羟基苯基)乙二胺配体取代效应对潜在肝脏PET/CT显像剂的药代动力学影响研究
Anne Zenner,Thomas Winkens,Marta Pomraenke et al.
Anne Zenner et al.
Four regioisomers of [68Ga]Ga-TMoS-DAZA, a PET/CT radio tracer for liver function imaging, were studied as candidates of potentially improved hepatobiliary biokinetics. Liver uptake and biliary clearance behavior were compared using an in o...