[18F]FMISO-PET imaging reveals the role of hypoxia severity in checkpoint blockade response [0.03%]
[18F]氟甲基碘氧乙烯正电子发射断层扫描显像揭示低氧水平严重程度在检查点封锁反应中的作用
Kaytlyn C McNeal,Kirsten M Reeves,Patrick N Song et al.
Kaytlyn C McNeal et al.
Context: Hypoxia within the tumor microenvironment is a critical factor influencing the efficacy of immunotherapy, including immune checkpoint inhibition. Insufficient oxygen supply, characteristic of hypoxia, has been re...
Application of copper (I) selective ligands for PET imaging of reactive oxygen species through metabolic trapping [0.03%]
铜(I)选择性配体在PET成像中通过代谢截获应用以成像活性氧物质
Tetsuro Tada,Yuki Mizuno,Yuki Shibata et al.
Tetsuro Tada et al.
Introduction: Reactive oxygen species (ROS) are attractive targets for clinical PET imaging. In this study, we hypothesized that PET imaging of ROS would be possible by using chelating ligands (L) that form stable complex...
Synthesis and evaluation of a 68Ga-labeled spermine derivative for tumor PET imaging [0.03%]
一种用于肿瘤PET成像的放射性六十八镓标记正四甲基二氨基乙烯衍生物的合成与评价研究
Kaixin Qin,Dongmei Shi,Yuzhou Zheng et al.
Kaixin Qin et al.
Background: The polyamine transporter system (PTS), which renders it a promising target for tumor therapy and imaging applications, facilitates the transmembrane transport of polyamines. We reported a novel derivative of ...
Initial insights into the interaction of antibodies radiolabeled with Lutetium-177 and Actinium-225 with tumor microenvironment in experimental human and canine osteosarcoma [0.03%]
抗体标记镥-177和锕-225与实验性人和犬骨肉瘤微环境的相互作用的初步见解
Sabeena Giri,Kevin J H Allen,Chandra Bose Prabaharan et al.
Sabeena Giri et al.
Background: Osteosarcoma (OS) is a prevalent primary bone cancer affecting both humans and canines. This study describes initial insights into the interaction of the human monoclonal antibody IF3 to an insulin-like growth...
PSMA-reactive NB7 single domain antibody fragment: A potential scaffold for developing prostate cancer theranostics [0.03%]
用于开发前列腺癌诊疗一体化的NB7单域抗体片段：靶向前列腺特异性膜抗原
Truc T Huynh,Yutian Feng,Rebecca Meshaw et al.
Truc T Huynh et al.
Introduction: Single domain antibody fragments (sdAbs) are an appealing scaffold for radiopharmaceutical development due to their small size (~15 kDa), high solubility, high stability, and excellent tumor penetration. Pre...
A third generation PSMA-targeted agent [211At]YF2: Synthesis and in vivo evaluation [0.03%]
一种针对PSMA的第三代放射性配体[211At]YF2：合成及体内评价
Yutian Feng,Rebecca L Meshaw,Sean W Finch et al.
Yutian Feng et al.
Introduction: Targeted α-particle therapy agents have shown promising responses in patients who have developed resistance to β--particle emitting radionuclides, albeit off-target toxicity remains a concern. Astatine-211...
Chemokine receptor PET imaging: Bridging molecular insights with clinical applications [0.03%]
趋化因子受体PET显像：从分子机制到临床应用
Chanelle Hunter,Benjamin Larimer
Chanelle Hunter
Chemokine receptors are important components of cellular signaling and play a critical role in directing leukocytes during inflammatory reactions. Their importance extends to numerous pathological processes, including tumor differentiation,...
Reduction of the hepatic radioactivity levels of [111In]In-DOTA-labeled antibodies via cleavage of a linkage metabolized in lysosomes [0.03%]
通过裂解在溶酶体中代谢的连接降低[111In]In-DOTA标记抗体的肝脏放射性水平
Hiroyuki Suzuki,Masato Matsukawa,Rikako Madokoro et al.
Hiroyuki Suzuki et al.
Introduction: Radiolabeled antibodies are promising tools for cancer diagnosis using nuclear medicine. A DOTA-chelating system is useful for preparing immuno-positron emission tomography and immuno-single-photon emission ...
Synthesis and evaluation of novel trifunctional chelating agents for pretargeting approach using albumin binder to improve tumor accumulation [0.03%]
一种新型三功能螯合剂的合成与评价用于使用白蛋白结合器的预靶向方法以提高肿瘤蓄积量
Shohei Tsuchihashi,Kazuma Nakashima,Hiroyuki Watanabe et al.
Shohei Tsuchihashi et al.
Introduction: The pretargeting approach consists of in vivo ligation between pre-injected antibodies and low-molecular-weight radiolabeled effectors. The advantage of the pretargeting approach is to improve a tumor-to-bac...
Tracking the fate of bacteria-derived site-specific immunomodulators by positron emission tomography [0.03%]
采用正电子发射断层扫描追踪细菌源性特异性免疫调节剂的命运
Alexia Kirby,Mojmír Suchý,Daniel Duan et al.
Alexia Kirby et al.
Introduction: Site-specific immunomodulators (SSIs) are a novel class of therapeutics made from inactivated bacterial species designed to regulate the innate immune system in targeted organs. QBECO is a gut-targeted SSI t...