Serge K Lyashchenko,Tuan Tran,Steffen Happel et al.
Serge K Lyashchenko et al.
Introduction: Zirconium-89 (89Zr) is a positron emitter with several advantages over other shorter-lived positron emission tomography (PET) compatible radiometals such as gallium-68 or copper-64. These include practically...
Evaluation of a bimodal, matched pair theranostic agent targeting prostate-specific membrane antigen [0.03%]
用于靶向前列腺特异性膜抗原的双模式配对治疗诊断剂的评估
Michael R Lewis,Alexander W Schaedler,Khanh-Van Ho et al.
Michael R Lewis et al.
Background: Prostate cancer affects 1 in 6 men, and it is the second‑leading cause of cancer-related death in American men. Surgery is one of the main treatment modalities for prostate cancer, but it often results in inc...
Transcatheter pseudo-vascular isolation for localization and concentration of a large molecule theranostic probe into a transgenic OncoPIG kidney tumor [0.03%]
经导管假血管隔离法用于转基因OncoPIG肾脏肿瘤内大型分子治疗诊断探针定位及浓集
Samuel L Rice,Fernando Gómez Muñoz,Jamaal Benjamin et al.
Samuel L Rice et al.
Introduction: Great strides have been made identifying molecular and genetic changes expressed by various tumor types. These molecular and genetic changes are used as pharmacologic targets for precision treatment using la...
An electrochemical generator for the continual supply of 213Bi from 225Ac for use in targeted alpha therapy applications [0.03%]
一种电化学连续制备靶向α治疗应用的213Bi(由225Ac生成)的发电机
Ryan Forrester,Guy Dutech,Andrew Akin et al.
Ryan Forrester et al.
Bismuth-213 is a radionuclide of interest for targeted alpha therapy and is supplied via a radiochemical generator system through the decay of 225Ac. Radionuclide generators employ longer lived "parent" radionuclides to routinely supply sho...
Actinium-225 photonuclear production in nuclear reactors using a mixed radium-226 and gadolinium-157 target [0.03%]
掺入226Ra和157Gd的目标在反应堆中产生225Ac的光核反应
Artem V Matyskin,Susanna B Angermeier,Saleem S Drera et al.
Artem V Matyskin et al.
Background: Actinium-225 is one of the most promising radionuclides for targeted alpha therapy. Its limited availability significantly restricts clinical trials and potential applications of 225Ac-based radiopharmaceutica...
Combining poly-epitope MoonTags and labeled nanobodies for signal amplification in cell-specific PET imaging in vivo [0.03%]
结合多表位MoonTag和纳米抗体标签在活体细胞特异性PET成像中放大信号
Katharina S Höffgen,Jennifer Dabel,Christian P Konken et al.
Katharina S Höffgen et al.
Immunorecognition provides an excellent basis for targeted imaging techniques covering a wide range from basic research to diagnostics and from single cells to whole organisms. Fluorescence- or radioisotope-labeled antibodies, antibody frag...
Target engagement of an anti-MT1-MMP antibody for triple-negative breast cancer PET imaging and beta therapy [0.03%]
用于三阴性乳腺癌PET显像和β治疗的特异性靶向MT1-MMP抗体
Natalia Magro,Marta Oteo,Eduardo Romero et al.
Natalia Magro et al.
Purpose: Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that lacks effective diagnostic and therapeutic options. Membrane type 1 matrix metalloproteinase (MT1-MMP) is an attractive bi...
Synthesis and characterization of 64Cu-labeled Geldanamycin derivative for imaging HSP90 expression in breast cancer [0.03%]
一种用于检测乳腺癌中HSP90表达的放射性铜同位素64Cu标记的格尔德安霉衍生物的合成与表征
Feng Li,Yubo Fan,Lan Zhou et al.
Feng Li et al.
Heat shock protein 90 (HSP90) plays a crucial role in cancer cell growth and metastasis by stabilizing overexpressed signaling proteins. Inhibiting HSP90 has emerged as a promising anti-cancer strategy. In this study, we aimed to develop an...
Preclinical evaluation of MC1R targeting theranostic pair [155Tb]Tb-crown-αMSH and [161Tb]Tb-crown-αMSH [0.03%]
靶向MC1R治疗诊断对[155Tb]Tb-crown-αMSH和[161Tb]Tb-crown-αMSH的临床前评估研究
Luke Wharton,Scott W McNeil,Chengcheng Zhang et al.
Luke Wharton et al.
Background: Targeted radionuclide therapy is established as a highly effective strategy for the treatment of metastatic tumors; however, the co-development of suitable imaging companions to therapy remains significant cha...
Study of activation cross sections of double neutron capture reaction on 193Ir for the reactor production route of radiotherapeutic 195mPt [0.03%]
研究反应堆生产治疗放射性同位素195mPt双中子俘获活化截面
Alexander S Madumarov,Nikolay V Aksenov,Gospodin A Bozhikov et al.
Alexander S Madumarov et al.
The radiotherapeutic 195mPt is among the most effective Auger electron emitters of the currently studied radionuclides that have a potential theranostic application in nuclear medicine. Production of 195mPt through double neuron capture of ...