Preoperative [18F]fluoro-PEG-folate PET/CT in advanced stage epithelial ovarian cancer: A safety and feasibility study [0.03%]
术前[18F]氟代聚乙二醇叶酸正电子发射断层扫描/X线计算机体层成像用于晚期上皮性卵巢癌患者：一项安全性及可行性研究
Isabeau A Ciggaar,Lysanne D A N de Muynck,Lioe-Fee de Geus-Oei et al.
Isabeau A Ciggaar et al.
Purpose: The selection for either primary or interval cytoreductive surgery (CRS) in patients with epithelial ovarian cancer (EOC) is currently based on imaging techniques like computed tomography (CT), [18F]fluorodeoxygl...
Towards imaging the immune state of cancer by PET: Targeting legumain with 11C-labeled P1-Asn peptidomimetics carrying a cyano-warhead [0.03%]
采用正电子发射断层扫描技术成像癌症免疫状态的研究：携带腈基-P1-Asn肽类模拟物靶向肿瘤半乳糖凝集素酶
Severin K Lustenberger,Claudia A Castro Jaramillo,Lena A Bärtschi et al.
Severin K Lustenberger et al.
Purpose: M2-type tumor-associated macrophages (TAM) residing in the tumor microenvironment (TME) have been linked to tumor invasiveness, metastasis and poor prognosis. M2 TAMs suppress T cell activation, silencing the rec...
Evaluation of heterotopic ossification maturity using SPECT/CT and PET/CT in preclinical model [0.03%]
利用SPECT/CT和PET/CT评估异位骨化成熟度的临床前模型研究
Shorouk Dannoon,Saud Alenezi,Abdelhamid Elgazzar
Shorouk Dannoon
Background: Heterotopic ossification (HO) is the formation of bone within soft tissue where bone normally does not exist. In general, it is characterized by highly active tissue with high bone turnover and rapid bone form...
The importance of radiochemical purity: Cellular binding and internalization of different radiometal chlorides in prostate cancer cells [0.03%]
放射化学纯度的重要性：不同放射金属氯化物在前列腺癌细胞中的结合和内吞作用
Julia Raitanen,Lena Palm,Marcus Hacker et al.
Julia Raitanen et al.
Radiometals play an important role in nuclear medicine, both for imaging and therapy. Binding studies represent an important step in the development of new radiolabeled ligands, as valuable insights into the binding properties can be gained...
Automation of simplified two-step radiolabeling via ditosylate synthon for 18F-labeled radiotracers using AllinOne module [0.03%]
使用AllinOne模块自动化二步合成放射示踪剂的简化放射标记途径（氟-18）
Shihong Li,Alexander Schmitz,Yu-Ting Lu et al.
Shihong Li et al.
Direct fluorination of a tosylate or mesylate precursor has been a wide-spread and reliable way for radio-fluorination. This approach can be difficult to achieve when the precursor cannot be easily obtained or is chemically unstable. A poss...
Production, purification and formulation of nanoradiopharmaceutical with 211At: An emerging candidate for targeted alpha therapy [0.03%]
使用211At生产、纯化和配制纳米放射药物用于靶向α治疗
Sanchita Ghosh,Debashis Banerjee,Apurav Guleria et al.
Sanchita Ghosh et al.
Introduction: Astatine-211 has attained significant interest in the recent times as a promising radioisotope for targeted alpha therapy (TAT) of cancer. In this study, we report the production of 211At via 209Bi (α, 2n) ...
Preclinical evaluation of [225Ac]Ac-crown-TATE - An alpha-emitting radiopharmaceutical for neuroendocrine tumors [0.03%]
89号锕元素-冠状-TATE-[225Ac]Ac-crown-TATE的神经内分泌肿瘤放射药的临床前评估
Aidan Ingham,Luke Wharton,Helena Koniar et al.
Aidan Ingham et al.
Background: Targeted alpha therapy (TAT) of somatostatin receptor-2 (SSTR2) positive neuroendocrine tumors (NETs) involving Ac-225 ([225Ac]Ac-DOTA-TATE) has previously demonstrated improved therapeutic efficacy over conve...
Structure-affinity-pharmacokinetics relationships of 111In-labeled PSMA-targeted ligands with different albumin binders [0.03%]
具有不同白蛋白结合剂的111In标记PSMA靶向配体的结构-亲和力-药代动力学关系研究
Keisei Yamaguchi,Nobuki Kazuta,Shohei Tsuchihashi et al.
Keisei Yamaguchi et al.
Introduction: Prostate-specific membrane antigen (PSMA) is a promising target for treating metastatic castration-resistant prostate cancer. Our previous report presented 111In- or 225Ac-labeled PSMA-NAT-DA1 (PNT-DA1) as a...
Preclinical investigation of the effect of stress on the binding of [18F]F13640, a 5-HT1A radiopharmaceutical [0.03%]
应激对五羟色胺1A放射性药物[18F]F13640结合的影响的临床前研究
Pierre Courault,Sandrine Bouvard,Caroline Bouillot et al.
Pierre Courault et al.
Background: [18F]F13640 is a new PET radiopharmaceutical for brain molecular imaging of serotonin 5-HT1A receptors. Since we intend to use this radiopharmaceutical in psychiatric studies, it is crucial to establish possib...
Synthesis and preclinical evaluation of [18F]AlF-NODA-MP-C6-CTHRSSVVC as a PET tracer for CD163-positive tumor-infiltrating macrophages [0.03%]
以CD163阳性肿瘤浸润巨噬细胞为靶点的正电子发射断层显像（PET）示踪剂[18F]AlF-NODA-MP-C6-CTHRSSVVC的合成及临床前评价
Bruna Fernandes,Ines F Antunes,Kavya Prasad et al.
Bruna Fernandes et al.
Positron emission tomography (PET) can provide information about tumor-associated macrophage (TAM) infiltration, as long as a suitable tracer is available. This study aimed to evaluate the radiolabeled peptide [18F]AlF-NODA-MP-C6-CTHRSSVVC ...