The potential of targeted radionuclide therapy to treat hypoxic tumor cells [0.03%]
靶向核素治疗用于缺氧肿瘤细胞治疗的潜力
S T M Wenker,S A M van Lith,G Tamborino et al.
S T M Wenker et al.
Tumor hypoxia contributes to cancer progression and therapy resistance. Several strategies have been investigated to relieve tumor hypoxia, of which some were successful. However, their clinical application remains challenging and therefore...
In vitro and in vivo study of 221Fr and 213Bi progeny release from the 225Ac-labelled TiO2 nanoparticles [0.03%]
一种标记的TiO₂纳米颗粒中²²⁵Ac及其衰变子体²²¹Fr和²¹³Bi的释放:离体和活体研究
Michal Sakmár,Ján Kozempel,Jan Kučka et al.
Michal Sakmár et al.
Background: Targeted alpha therapy (TAT) is an effective option for cancer treatment. To maximize its efficacy and minimize side effects, carriers must deliver radionuclides to target tissues. Most of the nuclides used in...
Convection-enhanced delivery of [177Lu]Lu-labeled gold nanoparticles combined with anti-PD1 checkpoint immunotherapy improves the survival of immunocompetent C57BL/6J mice with orthotopic GL261 murine glioma tumors [0.03%]
结合抗PD1检查点免疫疗法的[177Lu]Lu标记金纳米颗粒的对流增强递送可提高免疫Competent C57BL / 6J小鼠原位GL261小鼠胶质瘤肿瘤的生存率
Constantine J Georgiou,Madeline K Brown,Zhongli Cai et al.
Constantine J Georgiou et al.
Introduction: Our objective was to study convection enhanced delivery (CED) of 177Lu-labeled metal chelating polymer (MCP) conjugated to gold nanoparticles ([177Lu]Lu-MCP-AuNP) alone or combined with anti-PD1 immune check...
Brain drug delivery from the nasal olfactory region is enhanced using lauroylcholine chloride: An estimation using in vivo PET imaging [0.03%]
laureoyl氯化胆碱可增强经鼻嗅粘膜脑递药：小鼠体内PET研究
Shota Fukakusa,Chie Suzuki,Keita Sasaki et al.
Shota Fukakusa et al.
Introduction: Intranasal (IN) administration, often referred to as nose-to-brain (N2B) drug delivery, is an attractive approach for delivering drugs to the central nervous system. However, the efficacy of this method is l...
Evaluation of chelating agents based on pyridine-azacrown compounds H4PATA, PATAM, and H4PATPA for 68Ga and 177Lu [0.03%]
基于吡啶-氮冠醚化合物H4PATA、PATAM和H4PATPA的螯合剂评价及其对放射性核素68Ga和177Lu的影响研究
Anna A Shchukina,Anastasia D Zubenko,Oksana V Tarasenko et al.
Anna A Shchukina et al.
In this article, we present the synthesis and characterization of three macrocyclic chelators, H4PATA, PATAM, and H4PATPA, based on a pyridine-azacrown compound. Their complexation with 68Ga and 177Lu has been thoroughly investigated using ...
Cerebral and myocardial kinetics of [11C]acetoacetate and [11C]β-hydroxybutyrate: A comparative crossover study in healthy rats [0.03%]
乙酰乙酸和β-羟丁酸在健康大鼠脑组织和心肌中的动力学：交叉对照研究
Mette Louise Gram Kjærulff,Thien Vinh Luong,Gabriel Richard et al.
Mette Louise Gram Kjærulff et al.
Background: Ketone metabolism has been studied using positron emission tomography (PET) with the radiotracers [11C]acetoacetate and [11C]β-hydroxybutyrate. However, whether these two radiotracers actually yield equivalen...
Antimicrobial peptide LyeTx I mn∆K labeled with 68Ga is a potential PET radiopharmaceutical for molecular imaging of infections [0.03%]
标记68镓的抗菌肽LyeTx I mn∆K是感染分子成像的潜在PET放射药剂
Leonardo Lima Fuscaldi,Ana Claudia Ranucci Durante,Rosina Dapueto et al.
Leonardo Lima Fuscaldi et al.
Background: Antimicrobial peptides have been radiolabeled and investigated as molecular diagnostic probes due to their propensity to accumulate in infectious sites rather than aseptic inflammatory lesions. LyeTx I is a ca...
Filippo C Michelotti,Gregory Bowden,Wael Eter et al.
Filippo C Michelotti et al.
Purpose: Monitoring β-cell mass and function would provide a better understanding of diabetes, setting the stage for truly individualized therapies. We applied a combined PET/MRI protocol to monitor engrafted islets mass...
Influence of PEGylation on HER2-targeting retro A9 peptide analogue [0.03%]
聚乙二醇化对HER2靶向retro A9肽模拟物的影响
Sushree Arpitabala Yadav,V Kusum Vats,Rohit Sharma et al.
Sushree Arpitabala Yadav et al.
Elevated levels of HER2 receptor in breast cancer can be targeted through receptor-specific peptides for precise detection and therapy by nuclear medicine approach. Previously reported retro analogue of A9 peptide had shown HER2-specificity...
Gastrin-releasing peptide receptor as theranostic target in estrogen-receptor positive breast cancer: A preclinical study of the theranostic pair [55Co]Co- and [177Lu]Lu-DOTA-RM26 [0.03%]
雌激素受体阳性乳腺癌中胃泌素释放肽受体的诊疗靶点：放射性核素55Co-Co-DOTA-RM26和177Lu-Lu-DOTA-RM26的动物研究
Christina Baun,Birgitte Brinkmann Olsen,Carla Maria Lourenco Alves et al.
Christina Baun et al.
Background: Patients with advanced metastatic estrogen receptor-positive breast cancer often develop resistance to standard treatments, leading to uncontrolled progression. Thus, innovative therapies are urgently needed. ...