William C Eckelman,Chuen-Yen Lau,Ronald D Neumann
William C Eckelman
Imaging the myocardium at risk with ⁹⁹mTc-lactadherin administered after reperfusion in a porcine model [0.03%]
再灌注后给药99mTc-乳黏蛋白成像猪模型中的风险心肌
Runa H Poulsen,Jan T Rasmussen,Hans Erik Bøtker et al.
Runa H Poulsen et al.
Introduction: Phosphatidylserine is translocated from the inner to the outer leaflet of the plasma membrane in the early stages of apoptosis and necrosis and in reversibly injured cells. In rabbit hearts, ischemia followe...
PET imaging with [¹⁸F]fluoroethoxybenzovesamicol ([¹⁸F]FEOBV) following selective lesion of cholinergic pedunculopontine tegmental neurons in rat [0.03%]
PET 示踪剂[¹⁸F]氟乙氧基苯并维沙米酮([¹⁸F]FEOBV)成像小鼠选择性损毁胆碱能中脑被盖核神经元后的显像研究
Marilyn Cyr,Maxime J Parent,Naguib Mechawar et al.
Marilyn Cyr et al.
Introduction: [(18)F]fluoroethoxybenzovesamicol ([(18)F]FEOBV) is a PET radiotracer with high selectivity and specificity to the vesicular acetylcholine transporter (VAChT). It has been shown to be a sensitive in vivo mea...
Decreased ipsilateral [¹²³I]iododexetimide binding to cortical muscarinic receptors in unilaterally 6-hydroxydopamine lesioned rats [0.03%]
5-羟色胺损毁大鼠海马同侧区胆碱能受体结合力下降
Remco J J Knol,Kora de Bruin,Brent Opmeer et al.
Remco J J Knol et al.
Introduction: Dysfunction of the cholinergic neurotransmitter system is present in Parkinson's disease, Parkinson's disease related dementia and dementia with Lewy bodies, and is thought to contribute to cognitive deficit...
Biodistribution and antitumor effect of Cetuximab-targeted lentivirus [0.03%]
西妥昔单抗靶向 lentivirus 的体内分布及其抗肿瘤效果研究
Tuulia Huhtala,Minna U Kaikkonen,Hanna P Lesch et al.
Tuulia Huhtala et al.
Viral vectors are central tools for gene therapy. Targeting of the vector to desired tissues followed by expression of the therapeutic gene forms one of the most critical points in effective therapy. In this study we used streptavidin-displ...
In vitro and in vivo evaluation of the effects of aluminum [¹⁸F]fluoride radiolabeling on an integrin αvβ₆-specific peptide [0.03%]
体外及体内评价层粘连蛋白αvβ6-特异多肽的铝[18F]氟化物标记效应
Sven H Hausner,Nadine Bauer,Julie L Sutcliffe
Sven H Hausner
Introduction: Incorporation of fluorine-18 ((18)F) into radiotracers by capturing ionic [(18)F]-species can greatly accelerate and simplify radiolabeling for this important positron emission tomography (PET) radioisotope....
Comparative biodistributions and dosimetry of [¹⁷⁷Lu]DOTA-anti-bcl-2-PNA-Tyr³-octreotate and [¹⁷⁷Lu]DOTA-Tyr³-octreotate in a mouse model of B-cell lymphoma/leukemia [0.03%]
177Lu-DOTA-抗Bcl-2 PNA-Tyr3-奥曲肽和177Lu-DOTA-Tyr3-奥曲肽在B细胞淋巴瘤/白血病小鼠模型中的生物分布与剂量学研究比较
Ethan R Balkin,Dijie Liu,Fang Jia et al.
Ethan R Balkin et al.
Introduction: The B-cell lymphoma/leukemia-2 (bcl-2) proto-oncogene in non-Hodgkin's lymphoma (NHL) is a dominant inhibitor of apoptosis. We developed a (177)Lu-labeled bcl-2 antisense peptide nucleic acid (PNA)-peptide c...
Comparative Study
Nuclear medicine and biology. 2014 Jan;41(1):36-42. DOI:10.1016/j.nucmedbio.2013.10.006 2014
²¹³Bi-anti-EGFR radioimmunoconjugates and X-ray irradiation trigger different cell death pathways in squamous cell carcinoma cells [0.03%]
用于鳞状细胞癌的放射免疫药物²¹³Bi-抗EGFR和X射线辐射触发不同的细胞凋亡途径
Anja Pickhard,Guido Piontek,Christof Seidl et al.
Anja Pickhard et al.
Introduction: Treatment of patients with squamous cell carcinoma of head and neck is hampered by resistance of tumor cells to irradiation. Additional therapies enhancing the effect of X-ray irradiation may be beneficial. ...
Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach [0.03%]
基于常规分组方法的硬币注射比率方法在小鼠中的两种放射性示踪剂比较研究
Shuping Dou,Yuzhen Wang,Bruce Barton et al.
Shuping Dou et al.
Introduction: The differences between two agents often need to be accurately defined in vivo. Usually they are injected respectively into two groups of subjects. However, if the two agents do not interact with each other ...
Comparative Study
Nuclear medicine and biology. 2014 Jan;41(1):127-31. DOI:10.1016/j.nucmedbio.2013.10.001 2014
In vivo PET quantification of the dopamine transporter in rat brain with [¹⁸F]LBT-999 [0.03%]
体内[¹⁸F]LBT-999正电子发射断层显像定量法测定大鼠脑多巴胺转运蛋白
Sophie Sérrière,Clovis Tauber,Johnny Vercouillie et al.
Sophie Sérrière et al.
Introduction: We examined whether [(18)F]LBT-999 ((E)-N-(4-fluorobut-2-enyl)2β-carbomethoxy-3β-(4'-tolyl)nortropane) is an efficient positron emission tomography (PET) tracer for the quantification of the dopamine trans...