Novel dibutyl ether resin for the purification of the Auger emitter antimony-119 from tin targets [0.03%]
一种新型二丁基醚树脂用于从锡靶中纯化砹-119（Auger电子发射体）
Aivija Grundmane,Caterina F Ramogida,Valery Radchenko
Aivija Grundmane
Antimony-119 (119Sb, t1/2 = 38.19 h) is an Auger electron emitting radionuclide of interest for radiopharmaceutical therapy (RPT). The potential of 119Sb has only been explored theoretically, due to the absence of a suitable bifunctional ch...
Affinity maturation and optimization of CD44v6-targeting antibodies for molecular radiotherapy [0.03%]
用于分子放射治疗的CD44v6靶向抗体的亲和力成熟和优化
Anja Charlotte Lundgren Mortensen,Camilla Hofström,Helena Persson et al.
Anja Charlotte Lundgren Mortensen et al.
Aim: This study aimed to improve the efficacy of the CD44v6-targeting antibody UU-40 for molecular radiotherapy through affinity maturation and IgG subclass optimization. M&M: A panel of affinity-matured antibody candidat...
Biodistribution of [18F]BCPP-BF in humans: a first-in-human positron emission tomography study [0.03%]
[18F]BCPP-BF在人体内的生物分布：一项首次在人类中的正电子发射断层扫描研究
Kengo Sato,Tomoyasu Bunai,Akinori Oda et al.
Kengo Sato et al.
Introduction: [18F]BCPP-BF and [18F]BCPP-EF are PET probes used to evaluate mitochondrial function by targeting MC-I. Clinical studies on [18F]BCPP-EF have been reported, particularly brain studies. However, no reports ex...
Verena Pichler,Matthias Manfred Herth,Verena Hugenberg et al.
Verena Pichler et al.
The rapid growth of radiopharmaceutical sciences, driven by regulatory approvals of theranostic agents and the expanding role of PET imaging, underscores the need for sustainable and green practices. While radiopharmaceuticals offer high pr...
Radiation dosimetry of the 18 kDa translocator protein ligand [18F]PBR111 in humans [0.03%]
人受试者[18F]PBR111放射剂量学研究(18kDa转运蛋白配体)
Benjamin B Tournier,Zahra Mansouri,Yazdan Salimi et al.
Benjamin B Tournier et al.
Purpose: The 18 kDa translocator protein (TSPO) is a mitochondrial protein that becomes overexpressed during neuroinflammatory conditions, such as in Alzheimer's disease or multiple sclerosis. TSPO is of interest because ...
Corrigendum to "Alpha Atlas: Mapping global production of α-emitting radionuclides for targeted alpha therapy" [Nucl Med Biol (March-April 2025) 108990] [0.03%]
勘误表：“Alpha Atlas：全球生产用于靶向α疗法的α发射放射性核素的地图”[Nucl Med Biol (2025年3-4月) 108990]
Marianna Tosato,Chiara Favaretto,Janke Kleynhans et al.
Marianna Tosato et al.
IAEA activities to support the member states in the production of targeted alpha therapy radiopharmaceuticals [0.03%]
国际原子能机构支持成员国生产靶向阿尔法治疗放射性药物的活动
A R Jalilian,J Kleynhans,P Bouziotis et al.
A R Jalilian et al.
Due to the growing interest of International Atomic Energy Agency (IAEA) Member States in implementing targeted radionuclide therapy (TRT) in general, the demand for alpha-emitting radionuclides and radiopharmaceuticals is enormous. As an i...
Optimization and scale-up of [68Ga]Ga-FAPI-46 production on a Modular-Lab PharmTracer platform for clinical application [0.03%]
在模块化实验室PharmTracer平台上优化和放大[68Ga]Ga-FAPI-46的生产以供临床应用
Irene Brusa,Veronica Serena Cabitza,Stefano Emiliani et al.
Irene Brusa et al.
Background: Due to the increasing application of the fibroblast activation protein (FAP) targeting radiotracer [68Ga]Ga-FAPI-46 in cancer diagnostics by PET/CT, there is a need for a convenient way for routine production ...
Investigating the fate of Zirconium-89 labelled antibody in cynomolgus macaques [0.03%]
研究恒河猴体内89锆标记抗体的命运
Takanori Sasaki,Sadaaki Kimura,Akihiro Noda et al.
Takanori Sasaki et al.
Background: Preclinical pharmacokinetic studies of therapeutic antibodies in non-human primates are desired because of the difficulty in extrapolating ADME data from animal models to humans. We evaluated the pharmacokinet...
Terbium-161 in nuclear medicine: Preclinical and clinical progress in comparison with lutetium-177 [0.03%]
核医学中的铽-161：与镥-177相比的临床前和临床进展
František Trejtnar,Pavel Bárta,Ján Kozempel et al.
František Trejtnar et al.
The use of new radiopharmaceuticals labeled with lutetium-177 represents a successful translation of experimental results into clinical practice. Recent experimental data suggests that terbium-161 might well follow the example of lutetium-1...