Imane Bensalim,Lahcen Belyamani,Saber Boutayeb et al.
Imane Bensalim et al.
Prostate cancer is among the top causes of cancer-related mortality in men, according to the latest data from GLOBOCAN, driven primarily by androgen receptor signaling and initially treated with androgen deprivation therapy. However, most p...
Extracellular vesicles and their cargo molecules for peripheral nerve injuries and neuropathies: The composition, properties, and impact [0.03%]
外泌体及其货物分子在周围神经损伤和神经病中的作用：组成、特性及影响
Anam Anjum,Abel Lindley,Meaghan Harley-Troxell et al.
Anam Anjum et al.
Peripheral nerve repair remains a major clinical challenge due to limited functional recovery and the lack of effective therapeutic options. Extracellular vesicles (EVs) have emerged as potential mediators of nerve regeneration due to their...
Unravelling the mystery of hypoxia-induced miRNAs in breast cancer: A molecular cross-talk driving tumour progression and therapy resistance [0.03%]
揭秘乳腺癌低氧诱导的miRNA之谜：调控肿瘤进展和治疗抵抗的分子对话机制
Namrta Sharma,Varsha Yadav,Saket Sinha et al.
Namrta Sharma et al.
Breast cancer (BC) is estimated to be around 2.3 million new cases and 670 000 deaths in 2020 resulting it into the most frequent cancer globally and ranks fifth among mortalities. Numerous studies have established the link between BC and m...
Decoding the dialogue: The vagus nerve at the interface of brain, body, and Tumor [0.03%]
解读对话：迷走神经在大脑、身体和肿瘤之间的界面作用
Hao-Ran Dang,Wei-Lin Jin
Hao-Ran Dang
Cancer transcends a local disease by engaging in systemic crosstalk with the host's physiology. This review redefines the vagus nerve as a central bioelectric processor within a dynamic brain-body-tumor homeostatic network, orchestrating a ...
Doryan Masmoudi,Catherine Alix-Panabières,Zahra Eslami-S
Doryan Masmoudi
In cancer immunotherapy, peptide-major histocompatibility complexes are increasingly exploited as precise therapeutic targets. For instance, T-cell receptor (TCR)-engineered T cells, peptide vaccines, and TCR-mimic antibodies leverage the d...
Beyond 100 years of vitamin E and related molecules - Milestones and open challenges [0.03%]
超越维生素E及相关分子的百年历史——里程碑与未来挑战
Witt-Wallert Maria,Atkinson Jeffrey,Azzi Angelo et al.
Witt-Wallert Maria et al.
Over the past century, research on vitamin E has evolved from its initial identification as a fertility factor to the recognition of α-tocopherol (α-TOH) as an essential micronutrient with antioxidant and gene regulatory functions. Despit...
RNA editing of pathogenic variants causing inherited retinal diseases using endogenous ADAR-current and future perspectives [0.03%]
利用内源性ADAR编辑遗传性视网膜疾病致病突变的RNA修复当前和未来展望
Manar Salameh,Nina Schneider,Johanna Valensi et al.
Manar Salameh et al.
Inherited retinal diseases (IRDs) are a clinically and genetically heterogeneous group of disorders affecting millions worldwide, with limited therapeutic options for the majority of patients. Recent advances in RNA editing-particularly ade...
Advancing precision medicine in pancreatic cancer using novel biomarkers and clinical targets [0.03%]
运用新型生物标志物和临床靶点推进胰腺癌的精准医疗
Divya Murthy,Attila A Seyhan,Petra den Hollander et al.
Divya Murthy et al.
Precision-guided therapy is imperative in the battle against pancreatic ductal adenocarcinoma (PDAC), one of the most lethal solid malignancies with limited improvements in survival despite advances in molecular profiling and systemic thera...
Glucagon-like peptide-1 receptor agonists across anti-inflammation [0.03%]
胰高血糖素样肽-1受体激动剂的抗炎作用机制研究进展
Daohong Chen
Daohong Chen
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) can ignite the downstream signal transduction in various tissues/organs due to the receptor expression across cell types, thus playing multifaceted biological roles in and beyond anti-dia...
Dual-targeting strategies for cancer and diabetes: Converging pharmacological pathways and repurposed therapies [0.03%]
针对癌症和糖尿病的双重治疗策略：汇聚的药理通路与老药新用
Gurjit Kaur Bhatti,Ishtiaq Ahmed,Abhishek Sehrawat et al.
Gurjit Kaur Bhatti et al.
The rising global burden of cancer and diabetes mellitus, particularly type 2 diabetes (T2DM), underscores a critical need for integrated therapeutic strategies. Epidemiological studies reveal a compelling bidirectional association between ...