Vav3, a potential diagnostic and prognostic marker of diabetes, regulates glycolipid metabolism [0.03%]
Vav3是一种潜在的糖尿病诊断和预后标志物，可调节糖脂代谢
Chenmoji Wang,Mengjuan Wei,Yu Wang et al.
Chenmoji Wang et al.
Vav3 can significantly affect the energy metabolism of cancer cells by changing the cytoskeletal structure, involving the mechanism of disulfidptosis, while affecting the function of glucose transporters, regulating cellular glucose and lip...
Zinc bioavailability in alcohol-associated liver disease: Mechanisms and therapeutic implications [0.03%]
酒精相关性肝病中锌的生物利用度：机制及治疗意义
Yinrui Feng,Qingshan Yang,Dan Wang et al.
Yinrui Feng et al.
Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality worldwide. Hepatic zinc deficiency is a consistent feature of ALD, yet the therapeutic efficacy of zinc supplementation remains limited. This...
Membrane remodeling, ion channels, Ca2+ signaling, and stress pathways as molecular links between type 2 diabetes and cancer [0.03%]
膜重塑、离子通道、Ca2+信号转导和应激途径是2型糖尿病与癌症之间的分子联系
Gonzalo Ferreira,Luisina Chavarría,Agustín DeMarco et al.
Gonzalo Ferreira et al.
The interrelationship between type 2 diabetes mellitus (T2DM) and cancer reflects a convergence of molecular disturbances involving metabolism, inflammation, and cellular stress, often underpinned by genetic alterations. This review examine...
Multidimensional review of viral infectious ocular diseases: Post-Pandemic epidemiology and future directions for control [0.03%]
病毒性感染性眼病的多维度回顾：疫情后的流行病学及控制的未来方向
Chang Liu,Qianhao Yang,Yang Shen et al.
Chang Liu et al.
Viral Infectious Ocular Diseases (VIODs) remain a major global cause of vision loss, ranging from highly transmissible conjunctivitis to blinding keratitis and complex neuro-ophthalmic syndromes. Furthermore, the Coronavirus Disease 2019 (C...
Viral pathogens in bone- and bone-marrow derived malignancies: Friends or foes? [0.03%]
骨髓和骨髓来源的恶性肿瘤中的病毒病原体：朋友还是敌人？
Pei Liu,Weiwei Wang,Kun Zhao et al.
Pei Liu et al.
BONE: and bone-marrow associated cancers, including osteosarcoma, Ewing sarcoma, multiple myeloma, and various leukemias, are highly aggressive tumors with limited therapeutic options and poor outcomes. Viruses play a paradoxical role in th...
Precision gene therapy: Tailoring rAAV-mediated gene therapies for inherited retinal dystrophies (IRDs) [0.03%]
精准基因治疗：针对遗传性视网膜变性疾病的腺相关病毒介导的基因疗法个性化研究(I RDs)
Fábio Duarte,Yvan Arsenijevic
Fábio Duarte
Inherited retinal dystrophies (IRDs) are a heterogeneous group of rare genetic disorders that affect multiple retinal cell types, including photoreceptors, Müller glia, bipolar cells, retinal ganglion cells (RGCs), and the retinal pigment ...
Corrigendum to: "Unveiling the P2X7 receptor: Exploring its mechanisms, pathogenic role in ocular diseases, and emerging therapeutic potential" [Mol. Aspect. Med. 105 (2025) 101389 https://doi.org/10.1016/j.mam.2025.101389] [0.03%]
勘误：揭开P2X7受体的面纱——探索其机制、在眼部疾病中的致病作用及新兴治疗潜力[Mol. Aspect. Med. 105 (2025) 101389 https://doi.org/10.1016/j.mam.2025.101389]
Kai-Yang Chen,Hoi-Chun Chan,Chi-Ming Chan
Kai-Yang Chen
Published Erratum
Molecular aspects of medicine. 2025 Nov 12:101425. DOI:10.1016/j.mam.2025.101425 2025
Viruses in gastrointestinal cancers: Molecular pathogenesis, oncogenic mechanisms, and translational perspectives [0.03%]
胃肠肿瘤中的病毒：分子发病机制、致癌机制和转化前景
Bin Liu,Chengjiang Liu,Caroline Sunggip et al.
Bin Liu et al.
Viral pathogens are one of the most significant causes of human carcinogenesis, contributing to up to 15-20 % of worldwide cancers. The gastrointestinal (GI) tract is one of the most vulnerable human organ system to virus-mediated tumorigen...
Navigating the ocular barrier: Viral- and nanotechnology-based delivery systems as promising therapeutic agents for ocular diseases [0.03%]
基于病毒和纳米技术的递送系统在眼病治疗中的应用及发展前景
Subo Cai,Xiao Liang,Hongshuai Wu et al.
Subo Cai et al.
While the intricate and precisely specialized structure of the human eye is critical for its appropriate function, it also presents a number of anatomical and physiological barriers, such as tight junctions, enzymatic degradation, and dynam...
Pharmacological reprogramming of plitidepsin as a SARS-CoV-2 inhibitor [0.03%]
将plitidepsin药理重编程为SARS-CoV-2抑制剂
Jose Jimeno,Jose Felipe Varona,Jose A Lopez-Martin et al.
Jose Jimeno et al.
Selective pressures in the ocean promote the evolution of potent molecules that may be useful in therapeutic settings. Tunicates provide a rich source of bioactive molecules that have been shown to have anti-neoplastic and anti-microbial ac...