A catecholamine transporter from the human parasite Schistosoma mansoni with low affinity for psychostimulants [0.03%]
一种来自人类寄生虫血吸虫的儿茶酚胺转运蛋白，对精神兴奋剂的亲和力低
Mads B Larsen,Andréia C K Fontana,Lizandra G Magalhães et al.
Mads B Larsen et al.
The trematode Schistosoma mansoni is the primary cause of schistosomiasis, a devastating neglected tropical disease that affects 200 million individuals. Identifying novel therapeutic targets for the treatment of schistosomiasis is therefor...
Characterization of the DMAE-modified juvenile excretory-secretory protein Juv-p120 of Litomosoides sigmodontis [0.03%]
N-二甲基氨基乙醇对须毛嚢线虫幼虫分泌抗原Juv-p120的修饰研究
Ulrike Wagner,Jörg Hirzmann,Martin Hintz et al.
Ulrike Wagner et al.
Juv-p120 is an excretory-secretory 160 kDa glycoprotein of juvenile female Litomosoides sigmodontis and exhibits features typical for mucins. 50% of its molecular mass is attributed to posttranslational modifications with the unusual substi...
A genetic analysis of Plasmodium falciparum RNA polymerase II subunits in yeast [0.03%]
酵母中恶性疟原虫RNA聚合酶II亚基的遗传分析
Adonis Hazoume,Kambiz Naderi,Ermanno Candolfi et al.
Adonis Hazoume et al.
RNA polymerase II is an essential nuclear multi subunit enzyme that transcribes nearly the whole genome. Its inhibition by the alpha-amanitin toxin leads to cell death. The enzyme of Plasmodium falciparum remains poorly characterized. Using...
Genetic variability of the 18 kDa/HP6 protective antigen in Taenia saginata and Taenia asiatica: implications for vaccine development [0.03%]
钩球属绦虫18kDa/HP6保护性抗原的遗传变异及其对疫苗研发的影响
Luis M González,Raquel Ramiro,Luz García et al.
Luis M González et al.
Genomic characterization of the genes encoding the Taenia 18 kDa/HP6 protective antigens was carried out for Taenia saginata and T. asiatica using 42 taeniid isolates comprising 23 samples of T. saginata, 13 samples of T. asiatica and 6 sam...
Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3 [0.03%]
利什曼原虫糖原合成酶激酶-3的结构测定及其与布氏锥虫GSK-3抑制剂的结构活性比较关系研究
Kayode K Ojo,Tracy L Arakaki,Alberto J Napuli et al.
Kayode K Ojo et al.
Glycogen synthase kinase-3 (GSK-3) is a drug target under intense investigation in pharmaceutical companies and constitutes an attractive piggyback target for eukaryotic pathogens. Two different GSKs are found in trypanosomatids, one about ...
Peggy J Rooney,Lawrence Ayong,Crystal M Tobin et al.
Peggy J Rooney et al.
Polyphosphate is found in every cell, having roles in diverse processes, including differentiation and response to stress. In this study, we characterize a Toxoplasma gondii mutant containing an insertion within the carboxy-terminal end of ...
Fluorescence in situ hybridization (FISH) mapping of single copy genes on Trichomonas vaginalis chromosomes [0.03%]
应用于Trichomonas vaginalis染色体的单拷贝基因荧光原位杂交(FISH)定位技术
Zuzana Zubáčová,Vladimír Krylov,Jan Tachezy
Zuzana Zubáčová
The highly repetitive nature of the Trichomonas vaginalis genome and massive expansion of various gene families has caused difficulties in genome assembly and has hampered genome mapping. Here, we adapted fluorescence in situ hybridization ...
Futile import of tRNAs and proteins into the mitochondrion of Trypanosoma brucei evansi [0.03%]
无效的tRNA和蛋白质输入布氏无鞭毛体线粒体
Zdeněk Paris,Hassan Hashimi,Sijia Lun et al.
Zdeněk Paris et al.
Trypanosoma brucei brucei has two distinct developmental stages, the procyclic stage in the insect and the bloodstream stage in the mammalian host. The significance of each developmental stage is punctuated by specific changes in metabolism...
The role of a Brugia malayi p38 MAP kinase ortholog (Bm-MPK1) in parasite anti-oxidative stress responses [0.03%]
毕氏马来丝虫p38映射接头激酶同源物调控寄生虫抗氧化应激反应的功能研究
Akruti Patel,Agnieszka Nawrocka Chojnowski,Katie Gaskill et al.
Akruti Patel et al.
Filariasis, caused by thread-like nematode worms, affects millions of individuals throughout the tropics and is a major cause of acute and chronic morbidity. Filarial nematodes effectively evade host immunological responses and are long liv...
Glucose-6-phosphate dehydrogenase is the target for the trypanocidal action of human steroids [0.03%]
葡萄糖六磷酸脱氢酶是人类固醇滴虫杀灭作用的目标
Shreedhara Gupta,Artur T Cordeiro,Paul A M Michels
Shreedhara Gupta
Steroids such as dehydroepiandrosterone (DHEA) and epiandrosterone (EA) exert multiple effects in mammals including the inhibition of glucose-6-phosphate dehydrogenase (G6PDH). Initially, the inhibition was considered specific for the mamma...