The Trypanosoma brucei zinc finger protein ZC3H18 is involved in differentiation [0.03%]
锥虫锌指蛋白ZC3H18参与分化调控
Corinna Benz,Julius Mulindwa,Benard Ouna et al.
Corinna Benz et al.
In mammalian cells, the degradation of mRNAs that have AU-rich elements in their 3'-untranslated regions is accelerated by the binding of proteins that contain two CCCH-zinc-finger-domains. Three CCCH zinc-finger proteins, TbZFP1, TbZFP2, a...
Differential protein expression throughout the life cycle of Trypanosoma congolense, a major parasite of cattle in Africa [0.03%]
锥虫属刚地锥虫生命周期中蛋白质的差异表达式群分析
Brett A Eyford,Tatsuya Sakurai,Derek Smith et al.
Brett A Eyford et al.
Trypanosoma congolense is an important pathogen of livestock in Africa. To study protein expression throughout the T. congolense life cycle, we used culture-derived parasites of each of the three main insect stages and bloodstream stage par...
TcNDPK2, a Trypanosoma cruzi microtubule-associated nucleoside diphosphate kinase [0.03%]
TcNDPK2，克氏锥虫微管相关核苷二磷酸激酶
Mariana R Miranda,Maria de los Milagros Camara,León A Bouvier et al.
Mariana R Miranda et al.
Nucleoside diphosphate kinases (NDPKs) are enzymes required to preserve the intracellular nucleoside phosphate equilibrium. Trypanosoma cruzi has four putative nucleoside diphosphate kinases with unidentified biological roles and subcellula...
A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue [0.03%]
一种以氧化还原指标WST-1为检测手段的疟疾配子体杀灭活性筛选试验
Takeshi Q Tanaka,Kim C Williamson
Takeshi Q Tanaka
Efforts to move from malaria control to eradication will require new approaches to block malaria transmission, such as the development of anti-malarial drugs with gametocytocidal activity. Here fluorescent oxidoreduction indicator alamarBlu...
Martin Simuunza,Huseyin Bilgic,Tulin Karagenc et al.
Martin Simuunza et al.
The tick-borne protozoan parasite, Babesia bovis is one of the causes of bovine babesiosis, an economically important disease of cattle in tropical and sub-tropical countries. Using the recently published genome sequence of the parasite, we...
Malaria drug resistance is associated with defective DNA mismatch repair [0.03%]
疟疾药物耐药性与缺陷DNA错配修复相关
Meryl A Castellini,Jeffrey S Buguliskis,Louis J Casta et al.
Meryl A Castellini et al.
Malarial parasites exhibit striking genetic plasticity, a hallmark of which is an ever-increasing rate of resistance to new drugs, especially in Southeast Asia where multi-drug resistance (MDR) threatens the last line of antimalarial drugs,...
A survey of schistosome protein domain types: insights into unique biological properties [0.03%]
日本血吸虫蛋白质结构域类型的调查：独特的生物学特性的见解
Austin L Hughes,Robert Friedman
Austin L Hughes
Using the PROSITE database and search tools, we conducted a comprehensive bioinformatic analysis of the predicted protein sequences of the flatworm parasites Schistosoma mansoni and Schistosoma japonicum and seven other animal genomes in or...
Ana Brennand,Melisa Gualdrón-López,Isabelle Coppens et al.
Ana Brennand et al.
Eukaryotic cells can degrade their own components, cytosolic proteins and organelles, using dedicated hydrolases contained within the acidic interior of their lysosomes. This degradative process, called autophagy, is used under starvation c...
John Okombo,Eric Ohuma,Stephane Picot et al.
John Okombo et al.
The emergence and spread of antimalarial resistance remain burgeoning issues. Any strategy to slow down or overcome these problems requires an understanding of the genetic changes underlying this resistance. Quinine, the first antimalarial,...
The Hus1 homologue of Leishmania major encodes a nuclear protein that participates in DNA damage response [0.03%]
利什曼原毛膜虫的Hus1同源物编码一种参与DNA损伤反应的核蛋白
Vinicius S Nunes,Jeziel D Damasceno,Raimundo Freire et al.
Vinicius S Nunes et al.
The protozoan parasite Leishmania presents a dynamic and plastic genome in which gene amplification and chromosome translocations are common phenomena. Such plasticity hints at the necessity of dependable genome maintenance pathways. Eukary...