The Haemonchus contortus UNC-49B subunit possesses the residues required for GABA sensitivity in homomeric and heteromeric channels [0.03%]
无须翻译，或者可以翻译为较为通用的描述：“研究揭示了HaamonchuscontortusUNC-49B亚单位在同源和异源通道中具有GABA敏感性的必需残基”
Michael V Accardi,Sean G Forrester
Michael V Accardi
Hco-UNC-49 is a GABA receptor from the parasitic nematode Haemonchus contortus that has a relatively low overall sequence similarity to vertebrate GABA receptors but is very similar to the UNC-49 receptor found in the free living nematode C...
Transcriptional profiling of stage specific gene expression in the parasitic ciliate Ichthyophthirius multifiliis [0.03%]
寄生双星虫Ichthyophthirius multifiliis阶段特异性基因表达的转录谱分析
Donna M Cassidy-Hanley,Marie-Michèle Cordonnier-Pratt,Lee H Pratt et al.
Donna M Cassidy-Hanley et al.
The parasitic ciliate, Ichthyophthirius multifiliis (Ich), is among the most important protozoan pathogens of freshwater fish. Ichthyophthirius cannot be grown in cell culture, and the development of effective prophylactic and therapeutic t...
Enzymatic activity and immunolocalization of Schistosoma mansoni and Schistosoma haematobium neutral sphingomyelinase [0.03%]
曼氏血吸虫和尿血吸虫中性丝氨醇单胞磷脂酶的活性及免疫定位
Hatem Tallima,Mohammad Farhan Al-Halbosiy,Rashika El Ridi
Hatem Tallima
We predicted, and provided evidence for, the existence of a schistosome tegument-associated Mg(2+)-dependent neutral sphingomyelinase (nSMase), which controls hydrolysis of surface membrane sphingomyelin molecules, thus allowing nutrients, ...
Analysis of the transcriptome of the root lesion nematode Pratylenchus coffeae generated by 454 sequencing technology [0.03%]
使用454测序技术分析咖啡短体线虫根病变转录组文库及生物信息学分析
Annelies Haegeman,Soumi Joseph,Godelieve Gheysen
Annelies Haegeman
To study interactions between plants and plant-parasitic nematodes, several omics studies have nowadays become extremely useful. Since most data available so far is derived from sedentary nematodes, we decided to improve the knowledge on mi...
Plasmodium falciparum resistance to cytocidal versus cytostatic effects of chloroquine [0.03%]
恶性疟原虫对氯喹细胞杀灭作用和细胞周期阻滞作用的耐药性差异
Michelle F Paguio,Kelly L Bogle,Paul D Roepe
Michelle F Paguio
With one exception (Gligorijevic et al., Mol Biochem Parasitol 2008;159:7-23.) all previous quantification of chloroquine (CQ) potency vs. P. falciparum has been by growth inhibition assays, meaning potency is defined as cytostatic potentia...
A Gateway® compatible vector for gene silencing in bloodstream form Trypanosoma brucei [0.03%]
一种适用于环状文库形式基因沉默的吉门兼容型载体
Savitha Kalidas,Qiong Li,Margaret A Phillips
Savitha Kalidas
RNA interference is the most rapid method for generation of conditional knockdown mutants in Trypanosoma brucei. The dual T7 promoter (pZJM) and the stem-loop vectors have been widely used to generate stable inducible RNAi cell lines with t...
Secretion of a new spherical body protein of Babesia bovis into the cytoplasm of infected erythrocytes [0.03%]
巴贝斯氏体分泌新的球形体蛋白到感染的红血球细胞质中
Mohamad Alaa Terkawi,Faasoa Junior Seuseu,Putut Eko-Wibowo et al.
Mohamad Alaa Terkawi et al.
A cDNA encoding a new Babesia bovis spherical body protein 4 (BbSBP-4) was reported to have no significant homology to other apicomplexan proteins or previously reported B. bovis spherical body proteins. In the present study, we further exa...
Alexis A Cogswell,James J Collins rd,Phillip A Newmark et al.
Alexis A Cogswell et al.
The genome sequence for Schistosoma mansoni has been determined, allowing the complete protein complement to be predicted. However, few functional genomics techniques have been developed for use in S. mansoni, limiting the usefulness of the...
Clonorchis sinensis enolase: identification and biochemical characterization of a glycolytic enzyme from excretory/secretory products [0.03%]
从分泌抗原中鉴定并生化表征肝吸虫己糖单磷酸化酶
Xiaoyun Wang,Wenjun Chen,Fengyu Hu et al.
Xiaoyun Wang et al.
Enolase plays a key role in energy metabolism and development of most organisms. We isolated a gene encoding enolase from Clonorchis sinensis (C. sinensis) adult cDNA library and expressed the recombinant protein in Escherichia coli. C. sin...
Identification and functional characterization of CsStefin-1, a cysteine protease inhibitor of Clonorchis sinensis [0.03%]
人肺吸虫半胱天冬酶抑制剂CsStefin-1的鉴定及功能分析
Jung-Mi Kang,Kon-Ho Lee,Woon-Mok Sohn et al.
Jung-Mi Kang et al.
Cathepsin Fs of Clonorchis sinensis (CsCFs) are major secreted proteins that are expressed in the intestine of the parasite and play pivotal roles in parasite nutrition and host-parasite interactions. However, strict regulation of their act...