Ca2+-activated transbilayer movement of plasma membrane phospholipids in Leishmania donovani during ionomycin or thapsigargin stimulation [0.03%]
雷诺凡尼利什曼原虫在离子霉素或石蒜碱刺激下，细胞膜磷脂的跨层运动现象需钙离子参与
Adrien Weingärtner,Marcos Gonzaga dos Santos,Björn Drobot et al.
Adrien Weingärtner et al.
The protozoan parasite Leishmania causes serious infections in humans all over the world. After being inoculated into the skin through the bite of an infected sandfly, Leishmania promastigotes must gain entry into macrophages to initiate a ...
A transmembrane domain containing pellicle protein of Toxoplasma gondii enhances virulence and invasion after extracellular stress [0.03%]
弓形虫一种含有包囊壁结构域的膜蛋白在经历胞外压力后促进感染性和侵染性
T Matthew Payne,Peder J Lund,Laura J Knoll
T Matthew Payne
To identify Toxoplasma gondii genes important in the establishment of a persistent infection, we previously used signature-tagged mutagenesis to identify mutants with reduced cyst numbers in the brains of mice. One of the mutants, 95C5, has...
TSIDER1, a short and non-autonomous Salivarian trypanosome-specific retroposon related to the ingi6 subclade [0.03%]
一个短小且非自主的博氏泰勒虫属特异性逆转座子TSIDER1与ingi6亚支相关
Frédéric Bringaud,Matthew Berriman,Christiane Hertz-Fowler
Frédéric Bringaud
Retroposons of the ingi clade are the most abundant transposable elements identified in the trypanosomatid genomes. Some are long autonomous elements (ingi, L1Tc) while others, such as RIME and NARTc, are short non-coding elements that para...
A transcriptomic study on the pepsin-activated infective larvae of Angiostrongylus cantonensis [0.03%]
广东死亡雀鼠肺部 Cantonensis 异尖线虫病原体转录组学研究
Shih-Hsin Chang,Petrus Tang,Lian-Chen Wang
Shih-Hsin Chang
To investigate the pepsin-activated infective (third-stage) larvae of Angiostrongylus cantonensis at the transcriptomic level, 1496 ESTs were generated from a cDNA library and clustered into 161 contigs and 757 singletons. Among these unige...
Sarah J Tarr,R Ellen R Nisbet,Christopher J Howe
Sarah J Tarr
The antimalarial activity of the antibiotic thiostrepton has long been attributed to inhibition of apicoplast protein synthesis through binding of apicoplast ribosomal RNA. However, the kinetics of parasite death upon thiostrepton treatment...
Insights into blood feeding by schistosomes from a proteomic analysis of worm vomitus [0.03%]
基于蚯蚓呕吐的蛋白质组分析揭示出的血吸虫采血的新见解
Stephanie L Hall,Simon Braschi,Martha Truscott et al.
Stephanie L Hall et al.
Whilst the schistosome tegument has been intensively studied there is little information about processes in the gut, the other major interface with the bloodstream, apart from the well characterised cascade of proteases involved in haemoglo...
Joshua R Lacsina,Gregory LaMonte,Christopher V Nicchitta et al.
Joshua R Lacsina et al.
In the malaria parasite Plasmodium falciparum, global studies of translational regulation have been hampered by the inability to isolate malaria polysomes. We describe here a novel method for polysome profiling in P. falciparum, a powerful ...
Plasmodium falciparum enolase complements yeast enolase functions and associates with the parasite food vacuole [0.03%]
恶性疟原虫烯醇化酶具有酵母烯醇酶的功能并和寄生虫食物液泡相结合
Sujaan Das,Saudamini Shevade,Douglas J LaCount et al.
Sujaan Das et al.
Plasmodium falciparum enolase (Pfeno) localizes to the cytosol, nucleus, cell membrane and cytoskeletal elements, suggesting multiple non-glycolytic functions for this protein. Our recent observation of association of enolase with the food ...
Sabine A Stoffel,Vincent P Alibu,Jane Hubert et al.
Sabine A Stoffel et al.
A single copy gene, encoding a protein highly similar to transketolase from other systems, was identified in the Trypanosoma brucei genome. The gene was expressed in E. coli and the purified protein demonstrated transketolase activity with ...
A densely overlapping gene fragmentation approach improves yeast two-hybrid screens for Plasmodium falciparum proteins [0.03%]
一种密集重叠的基因分段方法可改进疟原虫蛋白质酵母双杂交筛选结果
Hakeenah F Brown,Ling Wang,Sudip Khadka et al.
Hakeenah F Brown et al.
Use of the yeast two-hybrid assay to study Plasmodium falciparum protein-protein interactions is limited by poor expression of P. falciparum genes in yeast and lack of easily implemented assays to confirm the results. We report here two met...