Nuclear actin-related protein is required for chromosome segregation in Toxoplasma gondii [0.03%]
与核相关Actin的蛋白质要求在Toxoplasma gondii中进行染色体分离
Elena S Suvorova,Margaret M Lehmann,Stella Kratzer et al.
Elena S Suvorova et al.
Apicomplexa parasites use complex cell cycles to replicate that are not well understood mechanistically. We have established a robust forward genetic strategy to identify the essential components of parasite cell division. Here we describe ...
Alternative 2-keto acid oxidoreductases in Trichomonas vaginalis: artifact of histochemical staining [0.03%]
解脲乳头瘤原虫中的替代型2-酮酸氧化还原酶：组化染色的误差
Věra Zedníková,Neritza Campo Beltrán,Jan Tachezy et al.
Věra Zedníková et al.
Trichomonas vaginalis has been reported to possess alternative 2-keto acid oxidoreductases (KORs). These enzymes preferentially used indolepyruvate in a reaction that resembled that of pyruvate:ferredoxin oxidoreductase (PFO). However, the ...
Candidate anthelmintic resistance-associated gene expression and sequence polymorphisms in a triple-resistant field isolate of Haemonchus contortus [0.03%]
从一个多重耐药的田野分离株中候选抗蠕虫药物相关基因表达和序列多态性
Sally M Williamson,Bob Storey,Sue Howell et al.
Sally M Williamson et al.
An isolate of Haemonchus contortus, UGA/2004, highly resistant to benzimidazoles, levamisole, and ivermectin was isolated from sheep at the University of Georgia, and passaged through experimentally infected goats. We measured the expressio...
Analysis of transcriptional regulation of tetracycline responsive genes in Brugia malayi [0.03%]
马来丝虫四环素响应基因转录调控分析
Canhui Liu,Patrick Vander Kelen,Elodie Ghedin et al.
Canhui Liu et al.
The Wolbachia endosymbiont of the human filarial parasites is necessary for parasite reproduction, making it an attractive chemotherapeutic target. Previous studies have demonstrated that mRNA levels of several nuclearly encoded genes are a...
A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes [0.03%]
一种针对恶性疟原虫晚期配子体高通量药物筛选的方法
Christopher L Peatey,Timothy P Spicer,Peter S Hodder et al.
Christopher L Peatey et al.
Recent success in the global reduction campaign against malaria has resulted in the possibility that it may be feasible to drastically reduce or even eradicate malaria even without the introduction of a vaccine. However, while there has bee...
Identification of phage display peptides with affinity for the tegument of Schistosoma japonicum schistosomula [0.03%]
用于日本血吸虫童虫包囊蛋白的肽指认及亲合力研究
Yan Liu,Paul J Brindley,Qingren Zeng et al.
Yan Liu et al.
Peptides, bound to the tegument of live Schistosoma japonicum schistosomula, were differentially screened by phage display in vitro using three rounds of reverse absorption and bio-panning. Three M13 phage peptides were isolated and identif...
Leishmania donovani encodes a functional enzyme involved in vitamin C biosynthesis: arabino-1,4-lactone oxidase [0.03%]
利什曼原塘ensis donovani存在参与维生素C生物合成的酶分子：阿拉伯糖1，4-内酯氧化酶
Neha Biyani,Rentala Madhubala
Neha Biyani
Plants and most animals can synthesize ascorbate (vitamin C) for their own requirements, but humans have lost this ability during evolution. The last step in the biosynthesis of L-ascorbic acid involves the conversion of an aldonolactone su...
IMP dehydrogenase deficiency in Leishmania donovani causes a restrictive growth phenotype in promastigotes but is not essential for infection in mice [0.03%]
利杜体 Donovan 巨噬细胞病缺泛 IMP 脱氢酶导致原mastigote生长受限，但不是感染小鼠所必需的
Audrey L Fulwiler,Jan M Boitz,Caslin Gilroy et al.
Audrey L Fulwiler et al.
Leishmania cannot synthesize purines de novo and therefore must scavenge purines from its host for survival and growth. Biochemical and genomic analyses have indicated that Leishmania species express three potential routes for the synthesis...
Spatial and temporal consistency of putative reference genes for real-time PCR in a model tapeworm [0.03%]
潜在参考基因的时空一致性及其在链状带绦虫中的应用性能评价
Natalia N Pouchkina-Stantcheva,Lucas J Cunningham,Peter D Olson
Natalia N Pouchkina-Stantcheva
Relative quantification of gene expression by real-time PCR relies on the use of reference genes whose expressed levels remain consistent across experimental conditions. Here we compare expression levels of commonly employed endogenous hous...
TsAg5, a Taenia solium cysticercus protein with a marginal trypsin-like activity in the diagnosis of human neurocysticercosis [0.03%]
TsAg5：一种具有轻微胰蛋白酶样活性的猪囊尾蚴蛋白在人类神经囊尾虫病诊断中的作用
Analiz Rueda,Cecilia Sifuentes,Robert H Gilman et al.
Analiz Rueda et al.
Neurocysticercosis is an endemic parasitic disease caused by Taenia solium larva. Although the mechanism of infection is not completely understood, it is likely driven by proteolytic activity that degrades the intestinal wall to facilitate ...