A tetrameric acetylcholinesterase from the parasitic nematode Dictyocaulus viviparus associates with the vertebrate tail proteins PRiMA and ColQ [0.03%]
一种来自寄生线虫Dictyocaulus viviparus的四聚乙酰胆碱酯酶与脊椎动物尾部蛋白PRiMA和ColQ相关联
Leo Pezzementi,Eric Krejci,Arnaud Chatonnet et al.
Leo Pezzementi et al.
Dictyocaulus viviparus causes a serious lung disease of cattle. Similar to other parasitic nematodes, D. viviparus possesses several acetylcholinesterase (AChE) genes, one of which encodes a putative neuromuscular AChE, which contains a try...
Darren J Creek,Jana Anderson,Malcolm J McConville et al.
Darren J Creek et al.
Metabolomics aims to measure all low molecular weight chemicals within a given system in a manner analogous to transcriptomics, proteomics and genomics. In this review we highlight metabolomics approaches that are currently being applied to...
TbENF is an essential TbTFIIB-interacting trypanosomatid-specific factor [0.03%]
TbENF是一种必不可少的与TbTFIIB相互作用的纤毛虫属特有因子
Kellie Whitecavage Solnoki,Allison H Sing,Caitlyn J Sofa et al.
Kellie Whitecavage Solnoki et al.
Trypanosoma brucei, the causative agent of African Sleeping Sickness, is replete with unique biochemistry, including unusual features of gene transcription. The parasite also contains over 4500 non-annotated genes, representing novel bioche...
Developmental regulation of gene expression in the absence of transcriptional control: the case of kinetoplastids [0.03%]
无转录控制下的基因表达调控——以动基体类寄生虫为例
Susanne Kramer
Susanne Kramer
Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi and Leishmania, are the only known organisms that do not regulate the transcription of protein coding genes transcribed by RNA polymerase II. Yet, profound ...
Andrea F N Rosenberger,Lydia Hangelmann,Andreas Hofinger et al.
Andrea F N Rosenberger et al.
The presence of xylose and galactose residues in the structure of trichomonad lipoglycans was indicated by previous studies and the modification of any glycoconjugate with either monosaccharide requires the respective presence of the nucleo...
Expression differential of microsomal and cytosolic glutathione-S-transferases in Fasciola hepatica resistant at triclabendazole [0.03%]
对三氯苯达唑抗性华枝睾吸虫微粒体和胞浆谷胱甘肽-S-转移酶的表达差异分析
S Scarcella,P Lamenza,G Virkel et al.
S Scarcella et al.
In the present work, we evaluate in vitro the cytosolic and microsomal activity of glutathione-S-transferases in adults of Fasciola hepatica susceptible (Cullompton Strain) and resistant (Sligo Strain) to triclabendazole. The triclabendazol...
A novel Entamoeba histolytica inositol phosphate kinase catalyzes the formation of 5PP-Ins(1,2,3,4,6)P(5) [0.03%]
一种新型的Entamoeba histolytica肌醇磷酸盐激酶催化形成5PP-Ins(1,2,3,4,6)P(5)
Benjamin Löser,Marcus M Nalaskowski,Werner Fanick et al.
Benjamin Löser et al.
The parasitic protozoan Entamoeba histolytica is able to invade human tissues by secreting proteolytic enzymes. This secretion is regulated by inositol phosphate-mediated Ca(2+) release from internal stores. To further investigate the inosi...
Piero Bagnaresi,Myna Nakabashi,Andrew P Thomas et al.
Piero Bagnaresi et al.
Regarded as the circadian hormone in mammals, melatonin is a highly conserved molecule, present in nearly all species. In this review, we discuss the role of this indolamine and its precursors in the cell biology of parasites and the role o...
Development of an efficient in vitro transcription system for bloodstream form Trypanosoma brucei reveals life cycle-independent functionality of class I transcription factor A [0.03%]
一种有效的体外转录系统的开发揭示了布氏锥虫血吸虫形式I类转录因子A的独立于生活周期的功能性
Sung Hee Park,Tu N Nguyen,Arthur Günzl
Sung Hee Park
Trypanosomatid parasites possess extremely divergent transcription factors whose identification typically relied on biochemical, structural and functional analyses because they could not be identified by standard sequence analysis. For exam...
Molecular and functional characterization of an Entamoeba histolytica protein (EhMLCI) with features of a myosin essential light chain [0.03%]
具肌球蛋白轻链特征的伊氏利什曼原虫（EhMLCI）蛋白的分子和功能表征
Isaura Meza,J Daniel Díaz-Valencia,Elizabeth Franco et al.
Isaura Meza et al.
Entamoeba histolytica, a protozoan parasite of humans, relays on its striking motility to survive and invade host tissues. Characterization of the molecular components involved in motile processes is crucial to understand its pathogenicity....