Biophysical analysis of the membrane-proximal Venus Flytrap domain of ESAG4 receptor-like adenylate cyclase from Trypanosoma brucei [0.03%]
隐翅虫ESAG4受体样腺苷酸环化酶的膜近端捕虫器结构域的生物物理分析
Desirée O Alves,Rob Geens,Hiam R da Silva Arruda et al.
Desirée O Alves et al.
The protozoan parasite Trypanosoma brucei possesses a large family of transmembrane receptor-like adenylate cyclases (RACs), primarily located to the flagellar surface and involved in sensing of the extracellular environment. RACs exhibit a...
Tissue and circulating levels of IL-17A and FoxP3+ in patients with scabies: Correlation with clinical features [0.03%]
疥疮患者IL-17A和FoxP3+的皮肤及血清水平变化及其临床意义
Amira M Matar,Wafaa A Shehata,Mona A Kora et al.
Amira M Matar et al.
The scabies mite is known to induce a complicated immune response that involves both innate and long-term adaptive immunity. Many immune effectors and pathways are involved. Th17/Treg balance can influence the complex immune response to sca...
Using machine learning to dissect host kinases required for Leishmania internalization and development [0.03%]
利用机器学习解析宿主泛素连接酶对利什曼原生动物胞吞和发育的依赖性
Ling Wei,Umaru Barrie,Gina M Aloisio et al.
Ling Wei et al.
The Leishmania life cycle alternates between promastigotes, found in the sandfly, and amastigotes, found in mammals. When an infected sandfly bites a host, promastigotes are engulfed by phagocytes (i.e., neutrophils, dendritic cells, and ma...
The genetically encoded calcium indicator GCaMP3 reveals spontaneous calcium oscillations at asexual stages of the human malaria parasite Plasmodium falciparum [0.03%]
基因编码的钙离子指示器GCaMP3揭示出人类疟原虫无性阶段的钙离子自发振荡现象
Benedito M Dos Santos,Mateus F Pecenin,Lucas Borges-Pereira et al.
Benedito M Dos Santos et al.
Most protocols used to study the dynamics of calcium (Ca2+) in the malaria parasite are based on dyes, which are invasive and do not allow discrimination between the signal from the host cell and the parasite. To avoid this pitfall, we have...
Neuroprotective effects of CysLT2R antagonist on Angiostrongylus cantonensis-induced edema and meningoencephalitis [0.03%]
APD86059(CYSLT2拮抗剂)对广州管圆线虫感染诱导脑水肿和脑膜脑炎的神经保护作用研究
Ke-Min Chen,Kuang-Ping Lan,Shih-Chan Lai
Ke-Min Chen
Cysteinyl leukotrienes (CysLTs) can induce a disruption of the blood-brain barrier (BBB), and this reaction is mediated by cysteinyl-leukotriene receptors. In this study, we used A. cantonensis-induced eosinophilic meningoencephalitis as a ...
Target screening using RNA interference in the sheep abomasal nematode parasite Haemonchus contortus [0.03%]
羊皱胃寄生线虫宿主的靶基因筛选及RNA干扰作用研究Haemonchus contortus
Charlotte Bouchet,Saleh Umair,Susan Stasiuk et al.
Charlotte Bouchet et al.
RNA interference (RNAi) on parasitic nematodes has been described as a valuable tool for screening putative targets that could be used as novel drug and/or vaccine candidates. This study aimed to set up a pipeline to identify potential targ...
Avirulent UG10 Entamoeba histolytica mutant derived from HM-1:IMSS strain shows limited genome variability and aberrant 5-methyl cytosine genomic distribution [0.03%]
无致病性的UG10突变体（来源于HM-1：IMSS株）显示有限的基因组变异及异常的5-甲基胞嘧啶基因分布特征
Naurú Idalia Vargas-Maya,Alika K Maunakea,Fátima Berenice Ramírez-Montiel et al.
Naurú Idalia Vargas-Maya et al.
Entamoeba histolytica, an intestinal parasite of global significance, poses substantial health risks with its associated high morbidity and mortality rates. Despite the current repertoire of molecular tools for the study of gene function in...
Therapeutic potential of hydantoin and thiohydantoin compounds against Schistosoma mansoni: An integrated in vitro, DNA, ultrastructural, and ADMET in silico approach [0.03%]
含氢苯并二氮杂卓和硫氢苯并二氮杂卓化合物抗曼氏血吸虫的药物作用机制及潜在治疗价值：体外、DNA、超微结构以及ADMET整合计算研究
Antônio Sérgio de Almeida Júnior,Mayse Manuele Freitas Viana Leal,Diego Santa Clara Marques et al.
Antônio Sérgio de Almeida Júnior et al.
The study aimed to conduct in vitro biological assessments of hydantoin and thiohydantoin compounds against mature Schistosoma mansoni worms, evaluate their cytotoxic effects and predict their pharmacokinetic parameters using computational ...
Strategies for diagnosing Nosema bombycis (Microsporidia: Nosematidae); the agent of pebrine disease [0.03%]
蚕微孢子虫(Pebrie病病原)的诊断策略
Masoumeh Bagheri,Shirin Dehghan,Azadeh Zahmatkesh
Masoumeh Bagheri
Pebrine disease, caused by Nosema bombycis (N. bombycis), is the most important pathogen known to the silk industry. Historical evidence from several countries shows that the outbreaks of pebrine disease have largely caused the decline of t...
Pyridopyrimidinones as a new chemotype of calcium dependent protein kinase 1 (CDPK1) inhibitors for Cryptosporidium [0.03%]
一种新的化学类型吡啶并嘧啶酮作为钙依赖性蛋白激酶1(CDPK1)抑制剂用于隐孢子虫病治疗
Elise Waldron-Young,Wissarut Wijitrmektong,Ryan Choi et al.
Elise Waldron-Young et al.
The protozoan protein kinase calcium-dependent protein kinase 1 (CDPK1) has emerged as a potential therapeutic target for the treatment of cryptosporidiosis. A focused screen of known kinase inhibitors identified a pyridopyrimidinone as a n...