Does hydrogen peroxide contribute to the immunity against Malaria induced by whole attenuated plasmodial sporozoites? [0.03%]
过氧化氢对完整减毒虫孢子体诱导的疟疾免疫有贡献吗？
Bruno Douradinha
Bruno Douradinha
Plasmodium sporozoites can block apoptotic pathways within host hepatocytes, ensuring the survival of the parasite. However, attenuated plasmodial sporozoites are unable to prevent apoptosis, which provides many parasite antigens to immune ...
Novel anti-Acanthamoebic properties of raloxifene sulfonate/sulfamate derivatives [0.03%]
新型抗阿米巴原虫类风湿素磺酸/磺酰胺衍生物的活性作用
Ruqaiyyah Siddiqui,Mohammed I El-Gamal,Sreedevi Sajeev et al.
Ruqaiyyah Siddiqui et al.
Acanthamoeba are known to cause a vision threatening eye infection typically due to contact lens wear, and an infection of the central nervous system. The ability of these amoebae to switch phenotypes, from an active trophozoite to a resist...
Amino acid usage and protein expression levels in the flatworm Schistosoma mansoni [0.03%]
曼氏血吸虫中氨基酸使用和蛋白质表达水平的研究
Guillermo Lamolle,Andrés Iriarte,Diego Simón et al.
Guillermo Lamolle et al.
Schistosoma mansoni is a parasitic flatworm that causes a human disease called schistosomiasis, or bilharzia. At the genomic level, S. mansoni is AT-rich, but has some compositional heterogeneity. Indeed, some regions of its genome are GC-r...
Evaluation of PEN2-ATP6AP1 axis as an antiparasitic target for metformin based on phylogeny analysis and molecular docking [0.03%]
基于系统发育分析和分子对接的二甲双胍抗寄生虫靶点PEN2-ATP6AP1轴评估研究
Congshan Liu,Shangrui Zhang,Jian Xue et al.
Congshan Liu et al.
Background: Metformin (Met), the first-line drug used in the treatment for type 2 diabetes mellitus, is effective against a variety of parasites. However, the molecular target of Met at clinical dose against various paras...
Coenzyme Q10 exhibits anti-inflammatory and immune-modulatory thereby decelerating the occurrence of experimental cerebral malaria [0.03%]
辅酶Q10展示抗炎和免疫调控功能从而延缓实验性脑疟疾的发生
James Nyabuga Nyariki,Njogu M Kimani,Peter Shikuku Kibet et al.
James Nyabuga Nyariki et al.
Cerebral Malaria (CM) is associated with the complex neurological syndrome, whose pathology is mediated by severe inflammatory processes following infection with Plasmodium falciparum. Coenzyme-Q10 (Co-Q10) is a potent anti-inflammatory, an...
Anti-parasitic activity of a chimeric peptide Cecropin A (2-8)-Melittin (6-9) (CM11) against tachyzoites of Toxoplasma gondii and the BALB/c mouse model of acute toxoplasmosis [0.03%]
融合肽CM11(Cecropin A(2-8)-Melittin(6-9))对刚地弓形虫速殖子抗虫活性及小鼠急性弓形虫病模型的研究
Zahra Abbasali,Majid Pirestani,Abdolhossein Dalimi et al.
Zahra Abbasali et al.
Toxoplasmosis is a zoonotic disease that infects most animals, including humans. Pyrimethamine/sulfadiazine is the standard treatment for toxoplasmosis. Although this treatment has been successful, it is often associated with side effects t...
Therapeutic activity of eugenol towards mitigation of anaemia and oxidative organ damage caused by Plasmodium berghei [0.03%]
肉桂醇对伯氏疟原虫所致贫血及氧化器官损伤的治疗作用
Mukhtar Adeiza Suleiman,Mohammed Aliyu Usman,Samson Olayinka Awogbamila et al.
Mukhtar Adeiza Suleiman et al.
The parasite responsible for causing malaria infection, Plasmodium, is known to exhibit resistance to a number of already available treatments. This has prompted the continue search for new antimalarial drugs ranging from medicinal plant pa...
Disruption of a DNA fragment that encodes the microneme adhesive repeat domain-containing region of the BBOV_III011730 does not affect the blood stage growth of Babesia bovis in vitro [0.03%]
靶向Bbov_III011730编码的微孢子虫粘附重复区DNA片段对巴贝斯虫血阶段体外生长的影响
Bumduuren Tuvshintulga,Azirwan Guswanto,Arifin Budiman Nugraha et al.
Bumduuren Tuvshintulga et al.
Babesia bovis, an intraerythrocytic hemoprotozoan parasite, causes the most pathogenic form of bovine babesiosis, negatively impacting the cattle industry. Comprehensive knowledge of B. bovis biology is necessary for developing control meth...
Diclazuril-induced expression of CDK-related kinase 2 in the second-generation merozoites of Eimeria tenella [0.03%]
迪克洛齐雷尔诱发球孢子虫第二代裂殖体的CDK相关激酶2表达
Bian-Hua Zhou,Hai-Yan Ding,Jing-Yun Yang et al.
Bian-Hua Zhou et al.
Diclazuril is a classic anticoccidial drug. The key molecules of diclazuril in anticoccidial action allows target screening for the development of anticoccidial drugs. Cyclin-dependent kinases (CDK) are prominent target proteins in apicompl...
Transgenic overexpression of heat shock protein (HSP83) enhances protein kinase A activity, disrupts GP63 surface protease expression and alters promastigote morphology in Leishmania amazonensis [0.03%]
热休克蛋白(HSP83)转基因过表达增强蛋白激酶A活性，破坏GP63表面蛋白酶的表达并改变利什曼原塘抗酸病原体亚马逊型无鞭毛体形态
Catherine S Nation,Isabel Stephany-Brassesco,Ben L Kelly et al.
Catherine S Nation et al.
Leishmania parasites undergo morphological changes during their infectious life cycle, including developmental transitions within the sandfly vector, culminating in metacyclic stages that are pre-adapted for infection. Upon entering vertebr...