GenBank-derived global inventory of benzimidazole resistance markers in the Haemonchus contortus β-tubulin 1 gene [0.03%]
源自GenBank的绵羊鼻腔线虫β-微管蛋白1基因中的苯并咪唑抗性标记物的全球目录
Abdullah Azeem,Muhammad Kasib Khan,Muhammad Shahid Mehmood et al.
Abdullah Azeem et al.
Haemonchus contortus is a highly pathogenic gastrointestinal nematode of ruminants and a major cause of production losses in small livestock systems. Its rapid life cycle and blood-feeding habit make it one of the most damaging helminths af...
Polygenic control of Rhipicephalus microplus infestation in purebred and crossbred cattle revealed by GWAS [0.03%]
全基因组关联研究揭示的纯种和杂交牛体内的Rhipicephalus microplus寄生多基因控制规律
M R S Simões,G S Campos,C C G Gomes et al.
M R S Simões et al.
Selecting cattle for enhanced resistance to ticks is essential for improving herd productivity and safeguarding animal welfare. In Brazilian production systems, tick resistance is a key factor influencing competitiveness in domestic and exp...
Knockdown resistance in mosquito vectors: Molecular mechanisms, global spread, and future directions for sustainable vector control [0.03%]
蚊虫载体的抗击倒性：分子机制、全球传播和可持续媒介控制的未来方向
S G Antony Godson
S G Antony Godson
Pyrethroid insecticides remain central to malaria and dengue vector control programmes. However, their long-term effectiveness is increasingly threatened by knockdown resistance (kdr). kdr arises from mutations in the voltage-gated sodium c...
Linda Sandblad,Lars Backman
Linda Sandblad
The Encephaliozoon cuniculi is an obligate intracellular microsporidian parasite with a highly reduced genome, yet it contains several key components of an actin cytoskeleton. In this study, we characterise the α-actinin-like protein from ...
Charlotte Bouchet,Jacqueline Knight,Sheralee Cleland et al.
Charlotte Bouchet et al.
In a recent study, bioinformatics and RNA interference (RNAi) were used to look for the genes responsible for the acute lethal or developmental arrest in Haemonchus contortus. Out of the fifty-six H. contortus genes selected as potential ta...
Kenneth Austin,Vincent A Obachi,Florence L Muzenda et al.
Kenneth Austin et al.
Trypanosoma cruzi, the etiological agent of Chagas disease, depends on glycolysis for ATP production, rendering its glycolytic enzymes attractive targets for therapeutic development. Here, we report the high-resolution crystal structures of...
In vitro and in silico evaluation of plant compounds as inhibitors of glutathione S-transferase from Rhipicephalus microplus and R. decoloratus [0.03%]
体外和计算机模拟评估植物化合物作为Rhipicephalus microplus和R.decoloratus谷胱甘肽S-转移酶抑制剂的效果
Wallyson André Dos Santos Bezerra,Claudia Quintino da Rocha,Itabajara da Silva Vaz Junior et al.
Wallyson André Dos Santos Bezerra et al.
Ticks are widely distributed ectoparasites that transmit several pathogens and cause significant losses in livestock production. Resistance to commercial acaricides has become increasingly common, stimulating the search for new molecules wi...
Exploring the potential role of Opisthorchis felineus infection in cholangiocarcinogenesis [0.03%]
探究猫肝吸虫感染在胆管癌发生中的潜在作用
Sidhant Jain
Sidhant Jain
The relationship between the liver fluke, Opisthorchis felineus (Of) and cholangiocarcinoma (CCA) has been assessed by a limited number of studies. In the case of animal models, such studies have pointed towards a causal association between...
Isolation and characterization of a novel glutamate-gated chloride channel subunit (GLC-2) from the canine heartworm Dirofilaria immitis [0.03%]
犬心丝虫谷氨酸门控氯离子通道新亚单位(GLC-2)的分离与鉴定
Jennifer Nichols,Sean G Forrester
Jennifer Nichols
Dirofilaria immitis is a parasitic nematode responsible for canine heartworm disease. Current heartworm treatment options include melarsomine chloridrate (an arsenical) to treat adult parasites and the macrocyclic lactones. Unfortunately, r...
Title: Multifunctional glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of parasites [0.03%]
题目：寄生虫多功能甘油醛-3-磷酸脱氢酶(GAPDH)
Pkk Mishra,P Joshi
Pkk Mishra
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an enzyme involved in glycolysis. However, non-glycolytic activities of this enzyme were subsequently discovered including DNA repair, cell death, membrane fusion and transport. Recent stu...