Dynamic modulation of Leishmania cytochrome c oxidase subunit IV (LmCOX4) expression in response to mammalian temperature [0.03%]
利什曼原虫细胞色素c氧化酶亚基IV(LmCOX4)的表达对哺乳动物体温的动态调节响应机制研究
Farhana Shaheen,Isabel Stephany-Brassesco,Ben L Kelly
Farhana Shaheen
The Leishmania LACK antigen is a ribosome-associated protein that facilitates expression of mitochondrial cytochrome c oxidase subunit IV (LmCOX4) to support parasite mitochondrial fitness and virulence within the vertebrate host. To furthe...
Diversity and natural selection of Merozoite surface Protein-1 in three species of human malaria parasites: Contribution from South-East Asian isolates [0.03%]
三种人类疟原虫的裂殖子表面蛋白-1多样性及自然选择：东南亚分离株的研究贡献
Xiang Ting Goh,Yvonne A L Lim,Ping Chin Lee et al.
Xiang Ting Goh et al.
The present study aimed to examine the genetic diversity of human malaria parasites (i.e., P. falciparum, P. vivax and P. knowlesi) in Malaysia and southern Thailand targeting the 19-kDa C-terminal region of Merozoite Surface Protein-1 (MSP...
Matthew W A Dixon,Leann Tilley
Matthew W A Dixon
The sexual blood stages of the human malaria parasite Plasmodium falciparum undergo a remarkable transformation from a roughly spherical shape to an elongated crescent or "falciform" morphology from which the species gets its name. In this ...
A GRA2 minimal promoter improves the efficiency of TATi / Tet-Off conditional regulation of gene expression in Toxoplasma gondii [0.03%]
改进弓形虫中TATi/Tet-Off条件性基因表达的效率
Mohammad Farouq Sharifpour,Shadi Khadiv,Markus Meissner et al.
Mohammad Farouq Sharifpour et al.
A tetracycline-responsive transcription system (Tet-Off) adapted for use in Toxoplasma gondii (nicknamed TATi) is useful for molecular biological studies of this organism. Previous studies using TATi incorporated minimal promoters derived f...
Cloning, purification, and characterization of the 6-phosphogluconate dehydrogenase (6 PGDH) from Giardia lamblia [0.03%]
兰伯氏贾第虫6-磷酸葡萄糖酸脱氢酶的克隆、纯化及鉴定
Laura Morales-Luna,Beatriz Hernández-Ochoa,Víctor Martínez-Rosas et al.
Laura Morales-Luna et al.
Giardia lamblia, due to the habitat in which it develops, requires a continuous supply of intermediate compounds that allow it to survive in the host. The pentose phosphate pathway (PPP) provides essential molecules such as NADPH and ribulo...
Petra Schneider,Sarah E Reece
Petra Schneider
Malaria parasites exhibit a complex lifecycle, requiring extensive asexual replication in the liver and blood of the vertebrate host, and in the haemocoel of the insect vector. Yet, they must also undergo a single round of sexual reproducti...
Identification and characterisation of a phospholipid scramblase in the malaria parasite Plasmodium falciparum [0.03%]
恶性疟原虫磷脂翻转酶的鉴定与表征
Silvia Haase,Melanie Condron,David Miller et al.
Silvia Haase et al.
Recent studies highlight the emerging role of lipids as important messengers in malaria parasite biology. In an attempt to identify interacting proteins and regulators of these dynamic and versatile molecules, we hypothesised the involvemen...
Vesicle dynamics during the egress of malaria gametocytes from the red blood cell [0.03%]
疟疾病原体配子体出胞过程中液泡的动态变化过程
Sandra Bennink,Gabriele Pradel
Sandra Bennink
Malaria parasites are obligate intracellular pathogens that live in human red blood cells harbored by a parasitophorous vacuole. The parasites need to exit from the red blood cell to continue life-cycle progression and ensure human-to-mosqu...
Recent achievements and doors opened for coccidian parasite research and development through transcriptomics of enteric sexual stages [0.03%]
肠道性阶段转录组学为球虫寄生虫研究和开发带来的近期成就与新机遇
Chandra Ramakrishnan,Nicholas C Smith
Chandra Ramakrishnan
The Coccidia is the largest group of parasites within the Apicomplexa, a phylum of unicellular, obligate parasites characterized by the possession of an apical complex of organelles and structures in the asexual stages of their life cycles,...
Wendy Gibson
Wendy Gibson
Much of the vast evolutionary landscape occupied by Eukaryotes is dominated by protists. Though parasitism has arisen in many lineages, there are three main groups of parasitic protists of relevance to human and livestock health: the Apicom...