De-novo discovery of posttranslational histone modifications in Schistosoma mansoni stages [0.03%]
受精卵细胞从头发现新型组蛋白修饰
Giulliana Galdini Costa,João Paulo da Luz Silva,Larissa Franco Moreira et al.
Giulliana Galdini Costa et al.
Schistosoma mansoni, a parasitic flatworm, causes schistosomiasis. Approximately 250 million people are infected and require drug treatment. Currently, Praziquantel is the only available drug, but it is ineffective against early infective s...
Probing the role of interfacial residues in the activity and structural stability of Adenylosuccinate lyase from Leishmania donovani [0.03%]
利什曼原点阿尼鲁丁酸裂解酶活性及结构稳定性的界面残基作用机理研究
Mochi Jigneshkumar A,Jani Jaykumar,Pappachan Anju
Mochi Jigneshkumar A
Leishmania donovani ADSL is a tetrameric protein involved in the purine metabolism where the active site is formed from residues belonging to three different subunits. In this study, the amino acid residues- E334, N335 and R370 of LdADSL we...
Comparative transcriptomics suggests conserved mechanisms of anhydrobiosis in the entomopathogenic nematode Heterorhabditis indica [0.03%]
比较转录组学表明粘缩线虫(indica)的干旱休眠机制是保守的
B Manimaran,J P Tejkumar,C Parameshwaran et al.
B Manimaran et al.
Anhydrobiosis is an evolutionarily conserved phenomenon observed across a diverse range of organisms. We have deployed a cross-species search to identify the homologs for anhydrobiosis-specific transcripts from Heterorhabditis indica. It re...
From Mystery to mechanism: The role of Base J in transcription termination and gene regulation in trypanosomatids and other kinetoplastids [0.03%]
从神秘到机制：碱基J在梨形鞭毛虫和其他动鞭毛目生物转录终止和基因调控中的作用
Ellie Watts,Veronica Harris,Terry K Smith
Ellie Watts
The modified nucleotide β-D-glucopyranosyloxymethyluracil (Base J) is found uniquely in kinetoplastids. Accumulating evidence has linked J to gene expression regulation, though its precise mechanistic role has remained elusive. Recent stud...
Preliminary in vitro evaluation of the immunomodulatory, schistosomicidal, antibacterial, antifungal, and antitumor activities of naphthyl-thiazole compounds [0.03%]
萘并噻唑类化合物的体外免疫调节、抗血吸虫、抗菌、抗真菌和抗肿瘤活性的初步评价
Karla Crystina Costa Dos Santos,Arthur Van Lauter Albuquerque Pereira,Arthur Félix Freire da Silva et al.
Karla Crystina Costa Dos Santos et al.
The search for new compounds with multiple therapeutic actions is crucial to address public health challenges such as microbial and parasitic resistance, as well as cancer. In this context, this study evaluated the in vitro immunomodulatory...
Temperature-dependent changes in lipid composition of the cestode Schistocephalus solidus [0.03%]
旋环虫（Schistocephalus solidus）脂质组成的温度依赖性变化
Ekaterina V Borvinskaya,Natalia N Fokina
Ekaterina V Borvinskaya
This study investigated lipid dynamics in larvae and sexually mature Schistocephalus solidus, a cestode parasite that transitions between cold-blooded fish and warm-blooded avian hosts. The lipid content was analyzed in relation to the envi...
Anti-inflammatory effects of valdecoxib found in Clonorchis sinensis excretory/secretory products in an Ankylosing Spondylitis [0.03%]
肝吸虫排泄/分泌产物中valdecoxib的抗炎作用在强直性脊柱炎中的研究
Yu Jeong Lee,Moon-Ju Kim,Sung Min Yu et al.
Yu Jeong Lee et al.
Clonorchis sinensis, a liver fluke, secretes immunomodulatory molecules that may suppress inflammation in autoimmune diseases such as ankylosing spondylitis (AS). However, the specific bioactive compounds involved remain largely unidentifie...
Multifaceted antimalarial effects of curcumin: Targeting PfGSK3, cytokine modulation, and histological improvements [0.03%]
姜黄素的多重抗疟效应：靶向PfGSK3、调节细胞因子及组织学改善作用
Amatul Hamizah Ali,Siti Nur Hidayah Jamil,Wan Rozianoor Mohd Hassan et al.
Amatul Hamizah Ali et al.
Curcumin, a polyphenolic compound exhibits various bioactivities, including antimalarial and anti-inflammatory effects. This study investigated the long-term antimalarial effects of curcumin through in vivo experiments using Plasmodium berg...
Molecular detection of chloroquine resistance in Plasmodium vivax isolates from North India: Analysis of single nucleotide polymorphisms in pvmdr1 gene [0.03%]
北印度地区卵形疟原虫氯喹抗药性的分子检测：pvmdr1基因单核苷酸多态性分析
Neha Nityadarshini,Raunak Bir,Jaya Biswas et al.
Neha Nityadarshini et al.
Objectives: Plasmodium vivax remains a major cause of malaria in India, with chloroquine still used as first-line therapy. However, molecular data on resistance markers are limited. This study aimed to detect mutations in...
Proteomic profiling of hydatid cyst fluid obtained in mouse strains exhibiting different susceptibility to secondary cystic echinococcosis [0.03%]
具有不同囊型细颈囊尾蚴病易感性的小鼠品系的水疱液蛋白质组分析
Ana Clara Muniz-Lagos,Marcela Cucher,María Clara González-Porcile et al.
Ana Clara Muniz-Lagos et al.
Cystic echinococcosis (CE), caused by Echinococcus granulosus sensu lato (s.l.), is a neglected tropical disease affecting over one million people worldwide. The proteomic composition of hydatid cyst fluid (HCF) varies depending on the host...