The essential cysteines in the CIPC motif of the thioredoxin-like Trypanosoma brucei MICOS subunit TbMic20 do not form an intramolecular disulfide bridge in vivo [0.03%]
布氏锥虫MICOS亚基TbMic20中的CIPC基序中的必要半胱氨酸在体内不形成分子内二硫键
Iosif Kaurov,Jiří Heller,Sebastian Deisenhammer et al.
Iosif Kaurov et al.
The mitochondrial protein import machinery of trypanosomatids is highly divergent from that of the well-studied models such as baker's yeast. A notable example is that the central catalyst of the mitochondrial intermembrane space import and...
Saranya Auparakkitanon,Prapin Wilairat,Prapon Wilairat
Saranya Auparakkitanon
Transcriptomic profiling of Bursaphelenchus xylophilus reveals differentially expressed genes in response to ethanol [0.03%]
乙醇应答性基因差异表达分析揭示了松材线虫的转录组谱型
Min Wang,Lin-Song Wang,Jun-Na Fang et al.
Min Wang et al.
Pinewood releases ethanol and other volatile compounds after Bursaphelenchus xylophilus infection. In the current study, we examined the influence of different ethanol concentrations on B. xylophilus reproduction. Low-concentrations of etha...
Protective immune potential of multiple antigenic peptide (MAP) constructs comprising peptides that are shared by several cysteine peptidases against Schistosoma mansoni infection in mice [0.03%]
数种半胱氨酸蛋白酶共有的多表位肽对曼氏血吸虫感染小鼠的免疫保护作用研究
Aya Al-Naseri,Samar Al-Absi,Noha Mahana et al.
Aya Al-Naseri et al.
In vaccine trials, Schistosoma mansoni cathepsin B1 (SmCB1), helminth cathepsins of the L family (e.g., SmCL3), and papain consistently induce highly significant reductions in challenge worm burden and egg viability, but generated no additi...
Alteration of the expression of sirtuins and var genes by heat shock in the malaria parasite Plasmodium falciparum [0.03%]
热休克对恶性疟原虫sirtuin及var基因表达的影响
Linda O Anagu,David R Hulse,Paul D Horrocks et al.
Linda O Anagu et al.
Background: In Plasmodium falciparum the monoallelic expression of var virulence genes is regulated through epigenetic mechanisms. A study in the Gambia showed that an increase in var genes commonly expressed in patients ...
The expression of cytokeratin and apoptosis-related molecules in echinococcosis related liver injury [0.03%]
棘球蚴病肝损害中细胞角蛋白及凋亡相关分子的表达
H C Yang,Z K Xing,H Shao et al.
H C Yang et al.
The study aimed to investigate the expression of cytokeratin and apoptosis-related molecules in the livers of two types of hepatic echinococcosis mice models and to preliminarily explore the relationship between the expression of cytokerati...
Plasmodium falciparum Cysteine Rich Secretory Protein uniquely localizes to one end of male gametes [0.03%]
疟原虫半胱氨酸丰富的分泌蛋白仅定位于雄配子的一端
Sudhir Kumar,Amanda S Leeb,Ashley M Vaughan et al.
Sudhir Kumar et al.
Fertilization is a central event during the life cycle of most eukaryotic organisms and involves gamete recognition and fusion, ultimately resulting in zygote formation. Gamete fertilization in the malaria-causing Plasmodium parasites occur...
Molecular mechanisms of hematological and biochemical alterations in malaria: A review [0.03%]
疟疾的血液学和生化改变的分子机制：综述
Innocent Uzochukwu Okagu,Rita Ngozi Aguchem,Chinonso Anthony Ezema et al.
Innocent Uzochukwu Okagu et al.
Malaria is a dangerous disease that contributes to millions of hospital visits and hundreds of thousands of deaths, especially in children residing in sub-Saharan Africa. Although several interventions such as vector control, case detection...
Codon usage in the flatworm Schistosoma mansoni is shaped by the mutational bias towards A+T and translational selection, which increases GC-ending codons in highly expressed genes [0.03%]
Schistosoma mansoni基因偏爱密码子的使用受A+T突变偏向和翻译选择的影响，这增加了高表达基因中以GC结尾的密码子的比例
Guillermo Lamolle,Andrés Iriarte,Héctor Musto
Guillermo Lamolle
Schistosoma mansoni is a trematode flatworm that parasitizes humans and produces a disease called bilharzia. At the genomic level, it is characterized by a low genomic GC content and an "isochore-like" structure, where GC-richest regions, m...
In vivo antibabesial activity and bioinformatic analysis of compounds derived from the Medicines for Malaria Venture box against Babesia microti [0.03%]
来源于医药防疟基金会化合物对巴贝斯虫体的体内和生物信息学分析
Mohamed Abdo Rizk,Shimaa Abd El-Salam El-Sayed,Rasha Eltaysh et al.
Mohamed Abdo Rizk et al.
Here, we have evaluated the inhibitory effects of Medicines for Malaria Venture (MMV) Malaria Box compounds that exhibited potent in vitro anti-bovine Babesia efficacy against the growth of B. microti in mice and conducted follow-up investi...