Evaluation of PEN2-ATP6AP1 axis as an antiparasitic target for metformin based on phylogeny analysis and molecular docking [0.03%]
基于系统发育分析和分子对接的二甲双胍抗寄生虫靶点PEN2-ATP6AP1轴评估研究
Congshan Liu,Shangrui Zhang,Jian Xue et al.
Congshan Liu et al.
Background: Metformin (Met), the first-line drug used in the treatment for type 2 diabetes mellitus, is effective against a variety of parasites. However, the molecular target of Met at clinical dose against various paras...
Coenzyme Q10 exhibits anti-inflammatory and immune-modulatory thereby decelerating the occurrence of experimental cerebral malaria [0.03%]
辅酶Q10展示抗炎和免疫调控功能从而延缓实验性脑疟疾的发生
James Nyabuga Nyariki,Njogu M Kimani,Peter Shikuku Kibet et al.
James Nyabuga Nyariki et al.
Cerebral Malaria (CM) is associated with the complex neurological syndrome, whose pathology is mediated by severe inflammatory processes following infection with Plasmodium falciparum. Coenzyme-Q10 (Co-Q10) is a potent anti-inflammatory, an...
Anti-parasitic activity of a chimeric peptide Cecropin A (2-8)-Melittin (6-9) (CM11) against tachyzoites of Toxoplasma gondii and the BALB/c mouse model of acute toxoplasmosis [0.03%]
融合肽CM11(Cecropin A(2-8)-Melittin(6-9))对刚地弓形虫速殖子抗虫活性及小鼠急性弓形虫病模型的研究
Zahra Abbasali,Majid Pirestani,Abdolhossein Dalimi et al.
Zahra Abbasali et al.
Toxoplasmosis is a zoonotic disease that infects most animals, including humans. Pyrimethamine/sulfadiazine is the standard treatment for toxoplasmosis. Although this treatment has been successful, it is often associated with side effects t...
Therapeutic activity of eugenol towards mitigation of anaemia and oxidative organ damage caused by Plasmodium berghei [0.03%]
肉桂醇对伯氏疟原虫所致贫血及氧化器官损伤的治疗作用
Mukhtar Adeiza Suleiman,Mohammed Aliyu Usman,Samson Olayinka Awogbamila et al.
Mukhtar Adeiza Suleiman et al.
The parasite responsible for causing malaria infection, Plasmodium, is known to exhibit resistance to a number of already available treatments. This has prompted the continue search for new antimalarial drugs ranging from medicinal plant pa...
Disruption of a DNA fragment that encodes the microneme adhesive repeat domain-containing region of the BBOV_III011730 does not affect the blood stage growth of Babesia bovis in vitro [0.03%]
靶向Bbov_III011730编码的微孢子虫粘附重复区DNA片段对巴贝斯虫血阶段体外生长的影响
Bumduuren Tuvshintulga,Azirwan Guswanto,Arifin Budiman Nugraha et al.
Bumduuren Tuvshintulga et al.
Babesia bovis, an intraerythrocytic hemoprotozoan parasite, causes the most pathogenic form of bovine babesiosis, negatively impacting the cattle industry. Comprehensive knowledge of B. bovis biology is necessary for developing control meth...
Diclazuril-induced expression of CDK-related kinase 2 in the second-generation merozoites of Eimeria tenella [0.03%]
迪克洛齐雷尔诱发球孢子虫第二代裂殖体的CDK相关激酶2表达
Bian-Hua Zhou,Hai-Yan Ding,Jing-Yun Yang et al.
Bian-Hua Zhou et al.
Diclazuril is a classic anticoccidial drug. The key molecules of diclazuril in anticoccidial action allows target screening for the development of anticoccidial drugs. Cyclin-dependent kinases (CDK) are prominent target proteins in apicompl...
Transgenic overexpression of heat shock protein (HSP83) enhances protein kinase A activity, disrupts GP63 surface protease expression and alters promastigote morphology in Leishmania amazonensis [0.03%]
热休克蛋白(HSP83)转基因过表达增强蛋白激酶A活性，破坏GP63表面蛋白酶的表达并改变利什曼原塘抗酸病原体亚马逊型无鞭毛体形态
Catherine S Nation,Isabel Stephany-Brassesco,Ben L Kelly et al.
Catherine S Nation et al.
Leishmania parasites undergo morphological changes during their infectious life cycle, including developmental transitions within the sandfly vector, culminating in metacyclic stages that are pre-adapted for infection. Upon entering vertebr...
Nian Wang,Zhuanling Zhang,Lisi Huang et al.
Nian Wang et al.
Clonorchis sinensis (C. sinensis) is a fish-borne trematode that inhabits the bile duct of mammals including humans, cats, dogs, rats, and so on. In the complex life cycle of C. sinensis, the worm develops successively in two intermediate h...
Characterization of 21 microsatellite loci for the precocious, grass-shrimp trematode Alloglossidium renale [0.03%]
21个引物位点用于鉴定草虾早期感染的肝吸虫（肾小袋壳虫）藻口肾病原体物种
Jenna M Hulke,Charles D Criscione
Jenna M Hulke
We developed microsatellite markers to use in studying the population genetics of the trematode Alloglossidium renale, a fluke with a precocious life cycle where sexual maturation occurs in a grass shrimp. Among 21 tested loci in a Mississi...
Characteristics of Th9 cells in Schistosoma japonicum-infected C57BL/6 mouse mesenteric lymph node [0.03%]
日本血吸虫感染小鼠肠系淋巴结Th9细胞的特征分析
Huaina Qiu,Ruohan Wang,Junmin Xing et al.
Huaina Qiu et al.
Interleukin 9 (IL-9) is an effective cytokine secreted by newly defined Th9 cells, which is involved in allergic and infectious diseases. In this study, lymphocytes were isolated from mesenteric lymph node (MLN), spleen, liver, lung, and Pe...