The activity and hydrogen peroxide sensitivity of the peroxiredoxins from the parasitic nematode Haemonchus contortus [0.03%]
圆线虫寄生线虫Haemonchus contortus过氧化物还原酶的活性及对过氧化氢的敏感性
Amanda L Hudson,Irene M Sotirchos,Mary W Davey
Amanda L Hudson
The requirement of aerobic organisms to control damage caused by reactive oxygen species has led to the evolution of the antioxidant systems. Peroxiredoxins are a large family of peroxidases which detoxify hydrogen peroxide at the expense o...
Evidence for prenylation-dependent targeting of a Ykt6 SNARE in Plasmodium falciparum [0.03%]
疟原虫中的牻牛儿焦磷酸化依赖性Ykt6 SNARE定位的证据
Lawrence Ayong,Thiago DaSilva,Jennifer Mauser et al.
Lawrence Ayong et al.
Ykt6 proteins are the most versatile fusogens in eukaryotic cells, and the only SNAREs that can be both prenylated and acylated at a C-terminal CAAX motif. Unlike yeast and mammalian cells where a single Ykt6 gene is expressed, the Plasmodi...
B J Davids,M A Gilbert,Q Liu et al.
B J Davids et al.
Proteolytic activity is important in the lifecycles of parasites and their interactions with hosts. Cysteine proteases have been best studied in Giardia, but other protease classes have been implicated in growth and/or differentiation. In t...
Hydrogenosome-localization of arginine deiminase in Trichomonas vaginalis [0.03%]
解脲支原体鸟氨酸脱羧酶定位于氢osomes
Mary Morada,Ondrej Smid,Vladimir Hampl et al.
Mary Morada et al.
The arginine dihydrolase (ADH) pathway has an analogous function to the urea cycle in mitochondria-containing cells, by removing nitrogen from amino acids and generating ATP. Subcellular localization of the ADH pathway enzymes in Trichomona...
Three acetylcholinesterases of the pinewood nematode, Bursaphelenchus xylophilus: insights into distinct physiological functions [0.03%]
松材线虫（Bursaphelenchus xylophilus）的三种乙酰胆碱酯酶：不同的生理功能分析
Jae Soon Kang,Dae-Weon Lee,Jae Young Choi et al.
Jae Soon Kang et al.
Acetylcholinesterase (AChE) plays a key role in postsynaptic transmission in most animals. Nematodes encode multiple AChEs, implying its functional diversity. To explore physiological functions of multiple AChEs, three distinct AChEs (BxACE...
The VSG C-terminal domain is inaccessible to antibodies on live trypanosomes [0.03%]
活锥虫体内的VSG C端结构域不受抗体系胞作用
Angela Schwede,Nicola Jones,Markus Engstler et al.
Angela Schwede et al.
In the mammalian host, the Trypanosoma brucei cell surface is covered with a densely packed protein coat of a single protein, the variant surface glycoprotein (VSG). The VSG is believed to shield invariant surface proteins from host antibod...
Complex I (NADH:ubiquinone oxidoreductase) is active in but non-essential for procyclic Trypanosoma brucei [0.03%]
布鲁氏锥虫的(procyclic) 复合体I（NADH：泛醌氧化还原酶）具有活性但非必需
Zdeněk Verner,Petra Cermáková,Ingrid Skodová et al.
Zdeněk Verner et al.
The requirement of complex I (NADH:ubiquionone oxidoreductase) for respiration in Trypanosoma brucei is controversial. Recent identification of homologues of its subunits in mitochondrial proteome resolved a question of its presence or abse...
Amornrat Geadkaew,Julia von Bülow,Eric Beitz et al.
Amornrat Geadkaew et al.
Fascioliasis, caused by liver flukes of the genus Fasciola, is an important disease of ruminants. In order to identify a potential new drug target we have studied aquaporin (AQP) in Fasciola gigantica. AQPs facilitate the transport of water...
Trypanosoma cruzi MSH2: Functional analyses on different parasite strains provide evidences for a role on the oxidative stress response [0.03%]
克氏锥虫MSH2功能分析：不同寄生虫菌株的分析结果为其在氧化应激反应中的作用提供了证据
Priscila C Campos,Viviane G Silva,Carolina Furtado et al.
Priscila C Campos et al.
Components of the DNA mismatch repair (MMR) pathway are major players in processes known to generate genetic diversity, such as mutagenesis and DNA recombination. Trypanosoma cruzi, the protozoan parasite that causes Chagas disease has a hi...
A rapid, efficient and economical method for generating leishmanial gene targeting constructs [0.03%]
一种快速、高效和经济的生成利什曼原虫基因敲除载体的方法
Audrey L Fulwiler,D Radika Soysa,Buddy Ullman et al.
Audrey L Fulwiler et al.
Targeted gene replacement is a powerful tool in Leishmania genetics that can be time-consuming to implement. One tedious aspect that delays progress is the multi-step construction of gene targeting vectors. To accelerate this process, we de...