Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei [0.03%]
Tob55在布氏锥虫线粒体蛋白质生物发生中的作用
Shvetank Sharma,Ujjal K Singha,Minu Chaudhuri
Shvetank Sharma
Mitochondrial outer membrane (MOM) proteins in parasitic protozoa like Trypanosoma brucei are poorly characterized. In fungi and higher eukaryotes, Tob55 is responsible for the assembly of β-barrel proteins in the MOM. Here we show that T....
Elucidation of IgE-binding epitopes of Ani s 1: the major Anisakis simplex allergen [0.03%]
解读IgE结合表位Anisakis simplex：主要的蛋白过敏原
Yukihiro Kobayashi,Kaori Ikeda,Kazuo Shiomi
Yukihiro Kobayashi
Ani s 1, the major allergen of Anisakis simplex, is expected to be a useful antigen in allergen-specific immunotherapy of Anisakis allergy. To avoid side-effects such as anaphylactic shock in immunotherapy, it is desirable to use not native...
The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei [0.03%]
调控型G蛋白ARL2对布氏冈比亚小睡病原虫分裂期的进行是必要的
Helen P Price,Adam Peltan,Meg Stark et al.
Helen P Price et al.
The Arf-like (Arl) small GTPases have a diverse range of functions in the eukaryotic cell. Metazoan Arl2 acts as a regulator of microtubule biogenesis, binding to the tubulin-specific chaperone cofactor D. Arl2 also has a mitochondrial func...
The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei [0.03%]
调控型G蛋白ARL2对布氏锥虫分裂中期所必需
Helen P Price,Adam Peltan,Meg Stark et al.
Helen P Price et al.
The Arf-like (Arl) small GTPases have a diverse range of functions in the eukaryotic cell. Metazoan Arl2 acts as a regulator of microtubule biogenesis, binding to the tubulin-specific chaperone cofactor D. Arl2 also has a mitochondrial func...
A fluorescence-based assay for the uptake of CPD0801 (DB829) by African trypanosomes [0.03%]
基于荧光的非洲锥虫摄取CPD0801(DB829)的检测方法
Christopher P Ward,Karl E V Burgess,Richard J S Burchmore et al.
Christopher P Ward et al.
Drug therapies currently used for second stage Human African Trypanosomiasis (HAT) exhibit problems with toxicity, difficulty of administration, and resistance linked to the loss of transporter function. Key to the development of new drugs ...
Echinococcus multilocularis primary cells: improved isolation, small-scale cultivation and RNA interference [0.03%]
Echinococcus multilocularis原虫细胞的分离、体外培养及RNA干扰技术的研究
Markus Spiliotis,Chiaki Mizukami,Yuzaburo Oku et al.
Markus Spiliotis et al.
In this study we demonstrate RNA interference mediated knock-down of target gene expression in Echinococcus multilocularis primary cells on both the transcriptional and translational level. In addition, we report on an improved method for g...
3-Methyladenine blocks Toxoplasma gondii division prior to centrosome replication [0.03%]
3-甲基腺嘌呤在中心体复制之前阻止弓形虫分裂
Yubao Wang,Anuradha Karnataki,Marilyn Parsons et al.
Yubao Wang et al.
The apicomplexan Toxoplasma gondii replicates by endodyogeny, in which replicated organelles assemble into nascent daughter buds within the maternal parasite. The mechanisms governing this complex sequence are not understood. We now report ...
Identification of Dirofilaria immitis immunoreactive proteins recognized by sera from infected cats using two-dimensional electrophoresis and mass spectrometry [0.03%]
应用二维电泳和质谱技术鉴定并筛选犬恶丝虫感染猫血清识别的抗原蛋白
Javier González-Miguel,Rodrigo Morchón,Mar Siles-Lucas et al.
Javier González-Miguel et al.
The aim of the present work was to identify proteins of Dirofilaria immitis recognized by the immune system of naturally and experimentally infected cats, using two-dimensional electrophoresis and mass spectrometry. Thirty-five immunoreacti...
Protoporphyrinogen IX oxidase from Plasmodium falciparum is anaerobic and is localized to the mitochondrion [0.03%]
来源于恶性疟原虫的原卟啉素IX氧化酶不依赖氧气且定位于线粒体中
Viswanathan Arun Nagaraj,Rajavel Arumugam,Dasari Prasad et al.
Viswanathan Arun Nagaraj et al.
Earlier studies in this laboratory had shown that the malarial parasite can synthesize heme de novo and inhibition of the pathway leads to death of the parasite. It has been proposed that the pathway for the biosynthesis of heme in Plasmodi...
Identification of three CCp genes in Babesia divergens: novel markers for sexual stages parasites [0.03%]
伯氏巴贝斯虫CCp基因的鉴定：性周期寄生虫的新标记
C A M Becker,L Malandrin,D Depoix et al.
C A M Becker et al.
Babesia divergens, a tick-borne protozoan parasite of red blood cells, is the main agent of bovine and human babesiosis in Europe. Very few data are available concerning its life cycle and sexual reproduction inside the tick vector, Ixodes ...