Role of PIP39 in oxidative stress response appears conserved in kinetoplastids [0.03%]
毕氏梨形虫和锥虫中的PIPs在氧化压力反应中扮演重要角色
Hina Durrani,James A Bjork,Sara L Zimmer
Hina Durrani
Kinetoplastids, a group of flagellated protists that are often insect intestinal parasites, encounter various sources of oxidative stress. Such stressors include reactive oxygen species, both internally produced within the protist, and indu...
Dynamics of the Trypanosoma cruzi infection in adipose tissue: Assessing gene expression of PNPLA2, FASN, and ACAT1 under Benzonidazole treatment and indirect mononuclear immune cells interaction [0.03%]
查加斯病原虫感染脂肪组织的动态变化：苯扎尼达唑治疗和间接单核免疫细胞相互作用下的PNPLA2，FASN 和ACAT1基因表达分析
Ana Carla da Silva,Leyllane Rafael Moreira,Cíntia Nascimento da Costa Oliveira et al.
Ana Carla da Silva et al.
Trypanosoma cruzi is a parasite with a high capacity to adapt to the host. Animal models have already demonstrated that the tropism of this parasite occurs not only in cardiac/digestive tissues but also in adipose tissue (AT). That said, th...
Formation of functional E3 ligase complexes with UBC2 and UEV1 of Leishmania mexicana [0.03%]
利什曼原虫E3连接酶复合物的形成及其与UBC2和UEV1的作用关系研究
Rebecca J Burge,Katie H Jameson,Vincent Geoghegan et al.
Rebecca J Burge et al.
In eukaryotic cells, molecular fate and cellular responses are shaped by multicomponent enzyme systems which reversibly attach ubiquitin and ubiquitin-like modifiers to target proteins. The extent of the ubiquitin proteasome system in Leish...
Plasmodium falciparum proteases as new drug targets with special focus on metalloproteases [0.03%]
疟原虫蛋白酶作为新的药物靶点及其金属蛋白酶研究进展
Prabhash Jyoti Mahanta,Kimjolly Lhouvum
Prabhash Jyoti Mahanta
Malaria poses a significant global health threat particularly due to the prevalence of Plasmodium falciparum infection. With the emergence of parasite resistance to existing drugs including the recently discovered artemisinin, ongoing resea...
Mapping the transporter-substrate interactions of the Trypanosoma cruzi NB1 nucleobase transporter reveals the basis for its high affinity and selectivity for hypoxanthine and guanine and lack of nucleoside uptake [0.03%]
对克氏锥虫NB1核碱基转运蛋白的转运体-底物相互作用进行mapping，揭示了其对次黄嘌呤和鸟嘌呤高亲和力和选择性的基础及缺乏核苷摄取的原因
Mustafa M Aldfer,Fabian Hulpia,Serge van Calenbergh et al.
Mustafa M Aldfer et al.
Trypanosoma cruzi is a protozoan parasite and the etiological agent of Chagas disease, a debilitating and sometimes fatal disease that continues to spread to new areas. Yet, Chagas disease is still only treated with two related nitro compou...
Sergio O Angel,Laura Vanagas,Andres M Alonso
Sergio O Angel
Toxoplasma has high host flexibility, infecting all nucleated cells of mammals and birds. This implies that during its infective process the parasite must constantly adapt to different environmental situations, which in turn leads to modifi...
A systematic review and meta-analysis on the current status of anthelmintic resistance in equine nematodes: A global perspective [0.03%]
马圆线虫抗驱虫药物机制的系统评价和元分析：全球视角
Enjia Cai,Rongzheng Wu,Yuhong Wu et al.
Enjia Cai et al.
Background: The intensive application of anthelmintics in equine has led to considerable resistance in cyathostomins and Parascaris equorum. It has been well documented that benzimidazole (BZ) and pyrantel resistance is w...
Alterations in the metabolism of Pseudosuccinea columella (Mollusca: Gastropoda) caused by Heterorhabditis bacteriophora HP88 (Rhabditida: Heterorhabditidae) [0.03%]
球盖盘螺(Pseudosuccinea columella)(腹足动物：柄眼亚纲)的代谢因细菌性异杆菌(Heterorhabditis bacteriophora HP88)(类圆线虫目：异杆科)而发生改变
Victor Menezes Tunholi,Natânia do Carmo Sperandio,Vinícius Menezes Tunholi-Alves et al.
Victor Menezes Tunholi et al.
The gastropod Pseudosuccinea columella participates in the dissemination of Fasciola hepatica in the environment, acting as the main intermediate host of this parasite in Brazil. The present study sought to elucidate the possible pathogenic...
Imaging of genomic loci in Trypanosoma brucei using an optimised LacO-LacI system [0.03%]
利用优化的LacO-LacI系统在布氏锥虫中对基因组位点进行成像
James Budzak,Ione Goodwin,Calvin Tiengwe et al.
James Budzak et al.
Visualisation of genomic loci by microscopy is essential for understanding nuclear organisation, particularly at the single cell level. One powerful technique for studying the positioning of genomic loci is through the Lac Operator-Lac Repr...
Elucidating the structure-function attributes of a trypanosomal arginyl-tRNA synthetase [0.03%]
揭示锥虫精氨酰-tRNA合成酶的结构功能属性
Pratyasha Bhowal,Bappaditya Roy,Sayak Ganguli et al.
Pratyasha Bhowal et al.
Aminoacyl-tRNA synthetases (aaRSs) are fundamental components of the protein translation machinery. In light of their pivotal role in protein synthesis and structural divergence among species, they have always been considered potential targ...