Immunological pathways triggered by Porphyromonas gingivalis in periodontitis: New insights into molecular mechanisms [0.03%]
牙龈卟啉单胞菌在牙周炎中激活的免疫学通路：分子机制新探
Klara Ferenc,Anna Bożek,Katarzyna Gawron
Klara Ferenc
Periodontitis (PD) is one of the most common chronic inflammatory diseases worldwide. One of the keystone causative agents of PD is considered an anaerobic, Gram-negative, opportunistic oral bacterium - Porphyromonas gingivalis, which has e...
Basmah M Eldakhakhny,Wesam H Abdulaal,Johra Khan et al.
Basmah M Eldakhakhny et al.
Pyroptosis is an inflammatory, necrotic, and lytic form of programmed cell death, involving activation of inflammasome complexes, inflammatory caspases, and the cleavage of gasdermins. Gasdermins are a large family of pore-forming proteins ...
Loss of GNB2L1 promotes expansion of CD74+ dendritic cells and contributes to development of diabetic foot ulcers [0.03%]
GNB2L1丢失促进CD74+树突状细胞扩增并参与糖尿病足溃疡发病发展
Yuan Wang,Bing Hang,Hongshan Liu et al.
Yuan Wang et al.
Refractory diabetic foot ulcers (DFUs) are characterized by low-grade chronic inflammation both locally and systemically. GNB2L1 has been reported to be associated with wound healing in diabetic rats, but the specific mechanism by which it ...
Fecal metabolomics in Crohn's disease reveal N-Acetylglutamine as a Th17/Treg modulator [0.03%]
基于代谢组学的粪便标志物发现黏膜免疫调节因子N-乙酰谷氨酰胺
Meijuan Han,Xuetao Dong,Ruxin Zhao et al.
Meijuan Han et al.
The gut microbiota is widely recognized as a key component in the pathogenesis of inflammatory bowel disease (IBD), and one of its primary modes of interaction with the host occurs via metabolites. Studies have confirmed that gut microbiota...
Coxsackievirus B3 regulates macrophage polarization through ANXA3 to promote the development of myocarditis [0.03%]
柯萨奇病毒B3通过ANXA3调节巨噬细胞极化以促进心肌炎的发展
Yanfei Chen,Xingzhu Liu,Lijuan Meng et al.
Yanfei Chen et al.
Background: Viral myocarditis (VMC) is a common inflammatory disease in children that is caused mainly by Coxsackievirus B3 (CVB3) infection. M1 macrophage polarization is a key pathological event in the progression of CV...
"Double-duty" dendritic cells in Xenopus laevis: Early vertebrate splenic APCs resemble conventional dendritic cells and limit native antigen presentation to B cells during a humoral response [0.03%]
非洲爪蟾Xenopus laevis的“一石二鸟”型树突状细胞：早期脊椎动物脾脏抗原递呈细胞类似于典型的树突状细胞，并通过限制初始体液免疫反应期间内源性抗原向B细胞的递呈，来控制生发中心的形成
Emily M Flowers,Xiwei Peng,Erik J Cruz et al.
Emily M Flowers et al.
XL cells are class IIhi, Ig-bearing cells found in splenic B cell follicles of the amphibian Xenopus laevis, bearing native antigen after immunization. XL cells are proposed to be myeloid cells serving the functions of both classical dendri...
Verticinone inhibits cell growth and induces pyroptosis via regulating AKT pathway in papillary thyroid cancer [0.03%]
垂体甲状腺癌中_verticinone_通过调节_AKT_途径抑制细胞生长和诱导细胞焦亡
Xincheng Liu,Yang Liu
Xincheng Liu
Background: Verticinone, an alkaloid isolated from Fritillaria, exhibits a range of biological activities. This study aims to investigate the effects of verticinone on papillary thyroid carcinoma (PTC), the most prevalent...
CD38 knockout attenuates type 2 diabetic renal injury by downregulating p53 and Bax via the ERK/JNK signaling pathway [0.03%]
通过ERK / JNK信号传导途径下调p53和Bax可减轻CD38敲除引起的2型糖尿病肾脏损伤
Dan Li,Yuna Du,Huiqing Zhang et al.
Dan Li et al.
Background: Diabetic nephropathy (DN), the leading cause of end-stage renal disease (ESRD), imposes substantial burdens on patients' health and socioeconomic status. Although current therapies targeting blood pressure, gl...
Innovations, challenges, and gaps in the development of an effective vaccine against Neisseria gonorrhoeae, a narrative review [0.03%]
奈瑟氏淋球菌有效疫苗的研发创新、挑战与缺口：叙述性回顾
Narjes Noori Goodarzi,Mohammad Reza Pourmand
Narjes Noori Goodarzi
Neisseria gonorrhoeae, the causative agent of gonorrhea, accounts for over 87 million new cases annually. It poses a serious threat to global health due to its high antimicrobial resistance. The development of an effective gonorrhea vaccine...
Catalpol enhances mTORC1/HIF-1α/PDHK1-mediated oxidative metabolism that leads to promote the differentiation of Treg cells in RA [0.03%]
Catalpol通过增强mTORC1/HIF-1α/PDK1介导的氧化代谢促进RA中Treg细胞的分化
Qiaoyu Zhang,Furong Wang,Peng Ding et al.
Qiaoyu Zhang et al.
Rheumatoid arthritis (RA) is a chronic autoimmune disease in which regulatory T (Treg) cell dysfunction contributes to its pathogenesis, although the mechanisms regulating Treg differentiation remain unclear. In this study, the effects of C...