Be a GEM: Biocontained, environmentally applied, genetically engineered microbes [0.03%]
做个GEM（遗传增强型微生物）：生物体所固有、环境友好、基因工程改造的微生物
Tae Seok Moon
Tae Seok Moon
Technological advances in engineering biology or synthetic biology have enabled practical applications of genetically engineered microbes (GEMs), including their use as living diagnostics and vehicles for therapeutics. However, technologica...
Seung Ho Lee,Roemer Pott Hofstede,Adrián Noriega de la Colina et al.
Seung Ho Lee et al.
Implantable systems for neurological chronotherapy are poised to revolutionize the treatment of central nervous system diseases and disorders. These devices enable precise, time-controlled drug delivery aligned with the body's circadian rhy...
Circadian attributes of neurological and psychiatric disorders as basis for their medication chronotherapy [0.03%]
神经和精神系统疾病的昼夜特性及其药物治疗的昼夜节律疗法原理
Sepideh Khoshnevis,Michael H Smolensky,Shahab Haghayegh
Sepideh Khoshnevis
This review focuses on (i) 24 h patterns in the symptom intensity of common neurologic and psychiatric disorders and (ii) medications prescribed for their management that have a recommended administration time or schedule, presumably to pot...
Intranasal and inhaled delivery systems for targeting circadian dysfunction in neurodegenerative disorders, perspective and future outlook [0.03%]
鼻腔和吸入给药系统在神经退行性障碍昼夜节律功能紊乱靶向治疗中的应用展望
Rhearne Ryan,Mathew N Leslie,Patrick He et al.
Rhearne Ryan et al.
Synchronisation of the suprachiasmatic nucleus (SCN) driven endogenous clock, located within the central nervous system (CNS), and exogenous time cues, is essential for maintaining circadian rhythmicity, homeostasis and overall wellbeing. D...
Intranasal NAP (Davunetide): Neuroprotection and circadian rhythmicity [0.03%]
鼻内NAP（Davunetide）：神经保护和昼夜节律性
Artur Galushkin,Illana Gozes
Artur Galushkin
In this review we examine the neuroprotective potential of NAP (davunetide), a small peptide derived from Activity-Dependent Neuroprotective Protein (ADNP), in the context of neurodevelopmental and neurodegenerative disorders. ADNP, a prote...
Devices to overcome the buccal mucosal barrier to administer Therapeutic Peptides [0.03%]
用于克服颊黏膜屏障以给药治疗肽的装置
Sahil Malhotra,Thomas Lijnse,Eoin O&#x; Cearbhaill et al.
Sahil Malhotra et al.
Peptide therapeutics are important in healthcare owing to their high target specificity, therapeutic efficacy, and relatively low side effect profile. Injections of these agents have improved thetreatment of chronic diseases including autoi...
Modulating the electronic structure of graphdiyne-based nanomaterials for engineering nano-bio interfaces in biomedical applications [0.03%]
基于石墨炔纳米材料的能带调控在生物医学应用中的纳米-生物界面的构建
Hui Wang,Xiaoyu Zhang,Jing Liu et al.
Hui Wang et al.
Graphdiyne (GDY), a two-dimensional (2D) carbon allotrope featuring a unique electronic structure, has attracted considerable attention due to its outstanding properties and potential applications in various fields, particularly in biomedic...
Optical coherence tomography for noninvasive monitoring of drug delivery [0.03%]
用于非侵入性监测药物递送的光学相干断层扫描技术
Salavat Aglyamov,Kirill V Larin
Salavat Aglyamov
Optical Coherence Tomography (OCT) has revolutionized various medical imaging and diagnostics fields, offering unprecedented insights into the microstructural compositions of biological tissues. In recent years, OCT applications have been e...
Nanoparticles targeting the central circadian clock: Potential applications for neurological disorders [0.03%]
靶向中枢生物钟的纳米颗粒：在神经障碍中的潜在应用
Marion Le Meur,Jaime Pignatelli,Paolo Blasi et al.
Marion Le Meur et al.
Circadian rhythms and their involvement with various human diseases, including neurological disorders, have become an intense area of research for the development of new pharmacological treatments. The location of the circadian clock machin...
Targeting Tumor-Associated Microbiome: A New Aspect of Modulating Tumor Microenvironment for Cancer Therapy [0.03%]
靶向肿瘤相关微生物组：调控肿瘤微环境进行癌症治疗的新方面
Wantong Song,Leaf Huang
Wantong Song