Platinum-based therapeutics as emerging multi-modal radiosensitizers in glioblastoma treatment [0.03%]
基于铂的治疗作为胶质母细胞瘤治疗中新兴的多模式放射增敏剂
Ananya H Elati,Erika W Davies,Mark V Mishra et al.
Ananya H Elati et al.
Glioblastoma (GBM) is a highly lethal brain cancer with poor patient prognosis and limited treatment options. Standard-of-care therapy involves maximally safe surgical resection followed by radiation therapy (RT) in combination with the alk...
Stimuli-Activatable protein degraders for targeted Cancer therapy: From prodrug design to Nanoplatform applications [0.03%]
用于癌症治疗的刺激响应型蛋白降解剂：从前药设计到纳米平台应用
Xingyu Jiang,Yinuo Chen,Yunna Gao et al.
Xingyu Jiang et al.
Disruption of proteostasis represents a critical pathological mechanism driving tumorigenesis and progression. Proteolysis targeting chimera (PROTAC) and molecular glue operating via the ubiquitin-proteasome pathway have created new therape...
Zhiai Xu,Bruno De Geest,Haijun Yu et al.
Zhiai Xu et al.
High concentration subcutaneous biological drug products: challenges and advancements [0.03%]
高浓度皮下生物药产品：挑战与进展
Guangli Hu,Mikolaj Milewski,Yogita Krishnamachari et al.
Guangli Hu et al.
Subcutaneous (SC) administration is often a preferred approach for biologic therapeutics, offering enhanced convenience, improved patient adherence, and reduced healthcare costs compared to traditional intravenous (IV) infusion. The growing...
A strategic guide of techniques for biomedical and tissue engineering applications to measure mechanical properties of soft matter, eye and skin [0.03%]
用于生物医学和组织工程应用的战略技术指南，用于测量软物质、眼睛和皮肤的机械性能
Claudia Muñoz Villaescusa,Diana van der Ven,Miguel A Quetzeri-Santiago et al.
Claudia Muñoz Villaescusa et al.
A comprehensive understanding of tissue mechanics at the microscale is critical for advancing personalised therapies, controlled drug release, and tissue engineering. Characterising the mechanical properties of complex, soft biological mate...
Synergies between data science methods and innovative drug delivery technologies [0.03%]
数据科学方法与创新药物输送技术之间的协同作用
David A Winkler
David A Winkler
Most areas of science and technology and beyond are undergoing an almost unprecedented rate of change, driven largely by the rapid growth in automation and robotics, computational power, and AI and machine learning algorithms. Many areas of...
The predictive edge: modeling and simulation in drug product development [0.03%]
预测性优势：制药产品开发中的模型与模拟
Sanjay Konagurthu,Dineli T S Ranathunga,Stephanie Buchanan et al.
Sanjay Konagurthu et al.
It is well-known that drug development is challenging and a time- and resource-intensive endeavor. Historically, it has relied heavily on trial-and-error, empirical approaches that yield a low probability of success. Despite continuous effo...
Rebecca I Sienel,Nikolaus Plesnila
Rebecca I Sienel
Central nervous system (CNS) injuries-such as stroke, traumatic brain injury, and perinatal hypoxia-trigger complex secondary cascades involving oxidative stress, inflammation, and apoptosis that limit recovery and therapeutic efficacy. Rec...
Artificial intelligence and machine learning guided optimization in drug delivery [0.03%]
人工智能与机器学习在药物递送中的指导优化作用
Helena Ros,Natasha Chan,Michael T Cook et al.
Helena Ros et al.
The optimisation of drug delivery systems is a complex, multidimensional challenge involving the interplay of formulation composition, process parameters, and biological performance. Traditional empirical and statistical approaches are incr...
Technology for Nucleic Acid Delivery in the treatment of Hematological malignancies [0.03%]
核酸递送技术在血液系统恶性肿瘤治疗中的应用
Saba Abbasi Dezfouli,Hasan Uludağ,Mohammad Nasrullah et al.
Saba Abbasi Dezfouli et al.
Blood (hematological) cancers display a wide spectrum of etiologies that can be attributed to specific molecular and chromosomal changes. While the uncontrolled proliferation of blood cells could be controlled to some degree by conventional...