From molecule to absorption: a multiscale framework for subcutaneous biologic delivery [0.03%]
从分子到吸收：皮下生物制剂递送的多尺度框架
Mario de Lucio,Vivek Sree,Galen Shi et al.
Mario de Lucio et al.
Subcutaneous (SC) injection has become the preferred route for self-administered monoclonal antibodies (mAbs), yet achieving consistent bioavailability remains challenging because molecular-scale interactions (protein self-association) prop...
Pharmacokinetic modeling to optimize development and therapeutic potential of mAb-based therapies [0.03%]
基于药代动力学的建模优化开发单克隆抗体药物的治疗潜力
Xiaoqing Fan,Chengcong Chen,Lin Zhang et al.
Xiaoqing Fan et al.
Monoclonal antibody (mAb)-based therapies have revolutionized modern medicine, offering highly specific and effective treatments for a wide range of diseases, including cancer, autoimmune disorders, infectious diseases, and neurological con...
Harnessing reactive oxygen species for precision medicine: ROS-Activatable PROTACs for lung Cancer [0.03%]
利用活性氧物种进行精准医疗：ROS激活型降解剂在肺癌治疗中的应用
M Olazábal-Morán,C Blázquez-Barbadillo,E Pérez-Izquierdo et al.
M Olazábal-Morán et al.
Reactive oxygen species (ROS) play a pivotal role in maintaining cellular balance, functioning both as essential messengers in signaling pathways and as agents of oxidative damage. In cancer their influence is paradoxical: moderate ROS leve...
Protein-based nanocarriers in the management of hard-to-treat solid tumours [0.03%]
基于蛋白质的纳米载体在难治性实体瘤治疗中的应用
Alexander S Evtushenko,Beatriz Lozano Torres,Ljiljana Fruk
Alexander S Evtushenko
Despite a steady decline in overall cancer mortality, the survival rates of certain hard-to-treat cancers of the lung, liver, oesophagus, pancreas, and brain remain strikingly low. A key unmet need in this field is the development of effect...
Microphysiological systems to accelerate and De-risk AAV Gene therapy development [0.03%]
用于加速和降低AAV基因治疗研发风险的微生理系统
Patrizia Tornabene,Estelle Berreur,Adrian Roth et al.
Patrizia Tornabene et al.
While adeno-associated viral (AAV) vectors are the leading platform in gene therapy - with eight regulatory-approved products spanning multiple disease areas - their clinical performance remains only partially predictable. A major challenge...
Molecular Modeling and machine learning for predicting high-concentration antibody viscosity [0.03%]
分子模拟和机器学习预测高浓度抗体粘度
Dariya Baizhigitova,I-En Wu,Lateefat Kalejaye et al.
Dariya Baizhigitova et al.
High-concentration monoclonal antibody formulations are essential for subcutaneous delivery but often exhibit elevated viscosity, posing challenges in drug development, manufacturing, and administration. Understanding high concentration vis...
Nanodrug delivery systems in tumor immunotherapy: From immune activation to tumor reprogramming [0.03%]
肿瘤免疫治疗中的纳米药物递送系统：从免疫激活到肿瘤重编程
Dengxuan Mao,Bingqian Li,Jing Li et al.
Dengxuan Mao et al.
Nanodrug delivery systems (NDDSs) offer distinctive advantages in tumor immunotherapy, not only by enhancing drug distribution, targeting, and bioavailability but also by actively engaging in immune regulation through multiple mechanisms. I...
From conventional screening to self-driving discovery: Organ-on-Chip platforms as engines for AI-guided nanomedicine [0.03%]
从传统筛选到自主发现：器官芯片平台作为人工智能引导纳米药物的引擎
Kimia Asadi Jozani,Karen Shen,Nicky Anvarihamedani et al.
Kimia Asadi Jozani et al.
Nanoparticles have become an essential platform for next-generation drug delivery and therapeutic development, yet clinical translation remains limited by an incomplete understanding of their interactions within human biological systems. Or...
Wei Wang,Yuxin Fang,Chunquan Sheng
Wei Wang
While proteolysis-targeting chimeras (PROTACs) represent a breakthrough in targeted protein degradation (TPD), their applicability is restricted by fundamental limitations. Mechanistically, they are mainly limited to proteins with accessibl...
Paula K N Alves,Ian C Sutton,James D Byrne et al.
Paula K N Alves et al.
Gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H₂S), are small endogenously produced signaling molecules that regulate critical intra- and intercellular processes. These gases modulate ion channe...