From conventional screening to self-driving discovery: Organ-on-Chip platforms as engines for AI-guided nanomedicine [0.03%]
从传统筛选到自主发现：器官芯片平台作为人工智能引导纳米药物的引擎
Kimia Asadi Jozani,Karen Shen,Nicky Anvarihamedani et al.
Kimia Asadi Jozani et al.
Nanoparticles have become an essential platform for next-generation drug delivery and therapeutic development, yet clinical translation remains limited by an incomplete understanding of their interactions within human biological systems. Or...
Wei Wang,Yuxin Fang,Chunquan Sheng
Wei Wang
While proteolysis-targeting chimeras (PROTACs) represent a breakthrough in targeted protein degradation (TPD), their applicability is restricted by fundamental limitations. Mechanistically, they are mainly limited to proteins with accessibl...
Paula K N Alves,Ian C Sutton,James D Byrne et al.
Paula K N Alves et al.
Gasotransmitters, including nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H₂S), are small endogenously produced signaling molecules that regulate critical intra- and intercellular processes. These gases modulate ion channe...
Matrix-integrated microfluidic tumor models for evaluating drug delivery systems and pre-clinical testing [0.03%]
矩阵集成微流体肿瘤模型用于评估药物输送系统和临床前测试
Paula Guerrero-López,Pilar Alamán-Díez,Soraya Hernández-Hatibi et al.
Paula Guerrero-López et al.
Drug delivery research strongly depends on experimental models that faithfully mimic the tumor microenvironment (TME) and its barriers to evaluate therapeutic efficacy. Conventional systems provide valuable insights but suffer from some lim...
NanoTAC in targeted protein degradation: Intelligent delivery platforms and synergistic therapeutic paradigms [0.03%]
纳米TAC在靶向蛋白降解中的应用：智能递送平台与协同治疗范式
Jieying Qian,Hongtao Duan,Qingqi Zheng et al.
Jieying Qian et al.
Targeted protein degradation (TPD) has reshaped therapeutic strategy by catalytically eliminating pathogenic proteins through engagement with endogenous proteolytic systems. In contrast to conventional inhibitors that transiently block enzy...
Stimuli-responsive nanodiamonds for precision pharmacokinetics, pharmacodynamics, and drug delivery applications [0.03%]
具有刺激响应性的纳米钻石在精准药物动力学、药效学和药物递送中的应用
Iman Zare,Mansour Jafari,Shima Zahed Nasab et al.
Iman Zare et al.
Nanodiamonds (NDs) have emerged as versatile and promising nanocarriers in pharmacological applications, attributed to their distinctive physicochemical characteristics such as tunable size, customizable surface chemistry, and outstanding b...
Rashin Mohammadi,Stavros Stavrakis,Andew J deMello
Rashin Mohammadi
Transfection defines the process of introducing foreign biomolecules, such as DNA, RNA, liposomes, nanoparticles, antibodies and antibody fragments, into the cytoplasm or nucleus of a eukaryotic cell, with the aim of engineering or recoding...
Bridged PROTAC, DNA-based PROTAC and hydrophobic tag technologies for targeted protein degradation [0.03%]
用于靶向蛋白降解的PROTAC桥接技术、DNA基PROTAC技术和疏水标签技术
Pengcheng Gao,Yue Zhong,Kaixiu Luo et al.
Pengcheng Gao et al.
Proteolysis targeting chimeras (PROTACs) represent an important breakthrough in therapeutic discovery by leveraging the ubiquitin-proteasome system (UPS) to induce targeted protein degradation (TPD). Unlike conventional small-molecule inhib...
Challenges and developments in the manufacturing of high-concentration biotherapeutic monoclonal antibodies [0.03%]
高浓度生物治疗型单克隆抗体的制造面临的挑战与发展
Anurag S Rathore,Subhankar Metya,Rashmi Sharma et al.
Anurag S Rathore et al.
The past two decades have witnessed the rise of biotherapeutics as safe and effective solutions for curing or managing a spectrum of hard-to-treat diseases. Monoclonal antibodies (mAbs) form one of those most successful subclasses of biothe...
Microfluidics for separation, detection, and engineering of extracellular vesicles [0.03%]
微流控技术在细胞外囊泡分离、检测及工程化中的应用
Lamia A Heikal,Sherif I Hamdallah,Salma E El-Habashy et al.
Lamia A Heikal et al.
This review presents a clear and engaging exploration of how microfluidic technologies are reshaping the field of extracellular vesicle (EV) research, bridging technical innovation with clinical relevance. It aims to connect fundamental mic...