Garrett F Beeghly,Amid Shakeri,Fatemeh Mirzapour-Shafiyi et al.
Garrett F Beeghly et al.
The precise spatial organization of the heart across molecular, cellular, and tissue length scales underpins cardiac function. Recreating this architecture in engineered heart tissues remains a central challenge, as cardiac morphogenesis in...
From implantable to wearable: recent advances in microfluidic platforms for precision drug delivery [0.03%]
从植入式到可穿戴式：精密药物输送微流体平台的最新进展
Fatma Moawad,Shihao Pei,Alfonso Nieto-Argüello et al.
Fatma Moawad et al.
Wearable and implantable microfluidic drug delivery systems have emerged as promising platforms that address key limitations of conventional systems, including poor dosing control, variable bioavailability, and systemic toxicities. By enabl...
Lexie W Q Xi,Zhuojian Look,Clemence Bonnet et al.
Lexie W Q Xi et al.
The key characteristics of the cornea, its transparency and avascularity, emerge from spatial organization of cell populations, extracellular matrix layers, biomechanical properties, and morphogenic cues. This review translates these organi...
Scalable process technologies for human pluripotent stem cells (hPSCs) expansion and differentiation [0.03%]
人多能干细胞(hPSCs)的体外扩增与分化培养工艺开发技术scalable process technologies for human pluripotent stem cells (hPSCs) expansion and differentiation
Kevin Cyrys,Robert Zweigerdt
Kevin Cyrys
Human pluripotent stem cells (hPSCs) can serve as an unlimited, renewable "raw material" for essentially any therapeutic cell product, placing them at an exciting intersection of biology, manufacturing and the emerging field of regenerative...
Toward bioengineered muscle-fat microphysiological systems for sports medicine and obesity therapeutics [0.03%]
用于运动医学和肥胖症治疗的肌肉脂肪微生理系统生物工程技术研究方向
Min Young Kim,Anicca D Harriot,Deok-Ho Kim
Min Young Kim
Muscle injuries represent a major healthcare burden, yet we lack platforms capable of predicting human responses to exercise, injury, and therapeutic interventions. Muscle-on-chip (MoC) technologies can now reproduce physiological force gen...
Xuanbo Zhang,Changrong Shi,Pei Huang et al.
Xuanbo Zhang et al.
Redox imbalance is a defining feature of the tumor microenvironment (TME). Tumor cells adapt to this oxidative pressure through robust antioxidant pathways, whereas immune cells are easily impaired, leading to poor antigen presentation, com...
Cowpea mosaic virus as a candidate for intratumoral immunotherapy: progress, challenges, and future directions [0.03%]
豇豆花叶病毒作为瘤内免疫治疗候选物：进展、挑战和未来方向
Ayumi E Pottenger,Anthony O Omole,Nicole F Steinmetz
Ayumi E Pottenger
Immunotherapy has emerged as a new pillar of cancer therapeutics that utilizes the patient's own immune system to target tumor cells, a particular advantage in the context of hard-to-treat cancers. Virus-based immunotherapies have shown gre...
Editorial to "Hard-to-treat cancer: part II: drug delivery technologies and therapeutics strategies for pancreatic tumors, a hard-to-treat cancer" [0.03%]
难治性癌症的专论：第二部分——胰腺癌给药技术与治疗策略（针对难治性肿瘤）
África González-Fernández,Rosana Simón-Vázquez
África González-Fernández
High-dose subcutaneous Administration of Biologics: Overcoming barriers through formulation and device innovation [0.03%]
高剂量生物制剂皮下给药：通过制剂和设备创新克服障碍
Tarik A Khan,Deep Bhattacharya,Twinkle R Christian et al.
Tarik A Khan et al.
The therapeutic landscape for biologics is rapidly transitioning from intravenous (IV) to subcutaneous (SC) administration, offering significant benefits in cost reduction and patient convenience through enabling treatment in flexible care ...
High-dose biologics and bioconjugates delivery: Integrating molecular optimization with device design and routes of administration [0.03%]
高剂量生物制剂和生物缀合物的输送：结合分子优化与装置设计及给药途径
Naresh K Budhavaram,Kevin Harrison Duffy,Abraham H Abouzeid et al.
Naresh K Budhavaram et al.
In recent years, biologics-based modalities have increased significantly across various therapeutic areas. Monoclonal antibodies (mAbs) and emerging bioconjugates such as antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugat...