Opportunities for artificial intelligence and synthetic biology in designing living drug delivery systems [0.03%]
人工 intelligence 和合成生物学在活体药物递送系统设计中的机遇
Jason H Yang,Caleb J Bashor
Jason H Yang
Advances in artificial intelligence (AI) and synthetic biology are transforming biological research and biotechnology. These fields are for the first time enabling the design and development of human and bacterial cells that can serve as "l...
Artificial intelligence and machine learning in smart vaginal formulation development [0.03%]
人工智能与机器学习在智能阴道制剂开发中的应用
Deborah A Ogundemuren,Vivek Agrahari,Andrew P Wong et al.
Deborah A Ogundemuren et al.
Vaginal drug delivery in women's health remains underutilized and insufficiently studied, largely due to the complexity and dynamic nature of the vaginal microenvironment. Variations in vaginal pH, hormonal levels, and microbiota compositio...
Engineering the blood-brain barrier on chip: advances in preclinical drug penetration and disease modeling [0.03%]
芯片上的血脑屏障工程：临床前药物渗透和疾病建模的进展
Cheick Sissoko,Sarah Spitz,Zhengyu Zhang et al.
Cheick Sissoko et al.
The blood-brain barrier (BBB) remains the single most significant obstacle to the successful delivery of therapeutics to the central nervous system (CNS), with over 98% of small-molecule drugs failing to penetrate the brain parenchyma. Conv...
Single-atom nanozymes: Bridging atomic design and biomedical function through structure-activity-property relationships [0.03%]
单原子纳米酶：通过结构-活性-性质关系连接原子设计与生物医学功能
Sin Yuan Chong,Kang Liang,Jieying Liang
Sin Yuan Chong
Single-atom nanozymes (SAzymes), featuring atomically dispersed active sites with well-defined coordination environments, have emerged as a powerful nanoplatform for mimicking metalloenzyme activity with high catalytic precision. However, t...
Manufacturing process development strategies for high concentration biologic drug products: from downstream processing to fill-finish [0.03%]
高浓度生物药物产品的制造工艺开发策略：从下游工艺到最终配制和灌装过程
Rama Prajapati,Mittal Darji,Seyyed Majid Eslami et al.
Rama Prajapati et al.
There is a growing demand for high-concentration protein formulations (HCPFs), driven by certain therapeutics that require high doses and the volume limitations of subcutaneous administration. However, downstream processing and fill-finish ...
Engineering brain-penetrant PROTACs: Bridging molecular design and CNS delivery [0.03%]
工程穿透大脑的PROTACS：分子设计与CNS递送之间的桥梁
Xinuo Li,Jinran Li,Yuan Sun et al.
Xinuo Li et al.
The drug development for central nervous system (CNS) disorders, particularly neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, faces formidable challenges. While proteolysis-targeting c...
Nanotechnology enabled proximity-induced protein degradation from multiscale bottlenecks to precision therapeutics [0.03%]
从多尺度瓶颈到精准治疗的纳米技术介导的近端蛋白降解
Xiaoning Pan,Huiyuan Jin,Jian Song et al.
Xiaoning Pan et al.
Proximity-induced protein degradation (PIPD) extends pharmacological intervention beyond occupancy-based inhibition by exploiting endogenous proteasomal or lysosomal pathways to eliminate disease-relevant proteins. However, when targeted de...
Overcoming barriers to delivery of biologics by novel approaches and advanced delivery systems [0.03%]
通过新颖方法和先进递送系统克服生物制剂递送障碍
Stephen Dela Ahator,Silvia Franzè,Sybil Obuobi et al.
Stephen Dela Ahator et al.
Biologics is emerging as fastest growing field of drug development offering specificity and high therapeutic potential. However, their therapeutic efficacy is dependent on their route of administration and targeted delivery. Unlike small mo...
Bifunctional proximity-inducing strategies for targeted and programmable post-translational modifications [0.03%]
用于靶向和程序化蛋白质翻译后修饰的双功能临近诱导策略
Sadiya Tanga,Pallabi Das,Tuhin Baran Samoi et al.
Sadiya Tanga et al.
The development of proteolysis-targeting chimeras (PROTACs) from their initial idea to their rise as a more comprehensive platform for proximity-driven regulation of protein function is traced in this review. We describe the design principl...
Microfluidic reactors for the synthesis of inorganic and hybrid nanoparticles for drug delivery [0.03%]
用于药物传输的无机和杂化纳米颗粒合成的微流控反应器
Víctor Sebastián
Víctor Sebastián
Inorganic nanoparticles (NPs) have played a central role in the development of nanomedicine, offering unique physicochemical properties that enable imaging, therapy, and multifunctional drug delivery. Despite extensive progress, the clinica...