Breaking barriers in targeted Therapy: Advancing exosome Isolation, Engineering, and imaging [0.03%]
突破靶向治疗壁垒：推进外泌体分离、工程和成像技术的发展
Anastasiya Kostyusheva,Eugenia Romano,Neng Yan et al.
Anastasiya Kostyusheva et al.
Exosomes have emerged as promising tools for targeted drug delivery in biomedical applications and medicine. This review delves into the scientific advancements, challenges, and future prospects specifically associated with these technologi...
Yiqing Lu,Parinaz Jabbari,Anton Mukhamedshin et al.
Yiqing Lu et al.
Once an exotic add-on to fluorescence microscopy for life science research, fluorescence lifetime imaging (FLIm) has become a powerful and increasingly utilised technique owing to its self-calibration nature, which affords superior quantifi...
Light sheet fluorescence microscopy for monitoring drug delivery: Unlocking the developmental phases of embryos [0.03%]
用于监测药物输送的光片荧光显微镜：解锁胚胎发育阶段
Gagan Raju,Aymeric Le Gratiet,Giuseppe Sancataldo et al.
Gagan Raju et al.
Light sheet fluorescence microscopy (LSFM) has emerged as a transformative imaging technique in the study of drug delivery and embryonic development, offering high-resolution, real-time visualization with minimal phototoxicity. This review ...
Ting Hou,Xiaoling Huang,Jiahui Lai et al.
Ting Hou et al.
The microbiome, consisting of a wide range of both beneficial and harmful microorganisms, is vital to various physiological and pathological processes in the human body, including cancer pathogenesis. Tumor progression is often accompanied ...
3D printing of pharmaceutical dosage forms: Recent advances and applications [0.03%]
制药剂型的3D打印： recent 近期的 advances 进步和应用 应用
Tobias Auel,Aaron Felix Christofer Mentrup,Lee Roy Oldfield et al.
Tobias Auel et al.
Three-dimensional (3D) printing, also referred to as additive manufacturing, is considered to be a game-changing technology in many industries and is also considered to have potential use cases in pharmaceutical manufacturing, especially if...
Yuan Xiong,Mahesh N Samtani,Daniele Ouellet
Yuan Xiong
The last two decades have witnessed profound changes in how advanced computational tools can help leverage tons of data to improve our knowledge, and ultimately reduce cost and increase productivity in drug development. Pharmacometrics has ...
3D extrusion bioprinting of microbial inks for biomedical applications [0.03%]
用于生物医学应用的微生物墨水的3D挤出式生物打印技术
Nicolas Burns,Arjun Rajesh,Avinash Manjula-Basavanna et al.
Nicolas Burns et al.
In recent years, the field of 3D bioprinting has witnessed the intriguing development of a new type of bioink known as microbial inks. Bioinks, typically associated with mammalian cells, have been reimagined to involve microbes, enabling ma...
Monitoring kinetic processes of drugs and metabolites: Surface-enhanced Raman spectroscopy [0.03%]
监测药物及其代谢物的动力学过程：表面增强拉曼光谱法
Zhewen Luo,Haoran Chen,Xinyuan Bi et al.
Zhewen Luo et al.
Monitoring the kinetic changes of drugs and metabolites plays a crucial role in fundamental research, preclinical and clinical application. Raman spectroscopy (RS) is regarded as a fingerprinting technique that can reflect molecular structu...
Heqi Xu,Shaokun Zhang,Kaidong Song et al.
Heqi Xu et al.
Recently, the conventional criterion of "one-size-fits-all" is not qualified for each individual patient, requiring precision medicine for enhanced therapeutic effects. Besides, drug screening is a high-cost and time-consuming process which...
Visualizing kinetics of diffusional penetration in tissues using OCT-based strain imaging [0.03%]
基于OCT的应变成像在组织扩散渗透动力学可视化中的应用研究
Y M Alexandrovskaya,A A Sovetsky,E M Kasianenko et al.
Y M Alexandrovskaya et al.
We report a new application of the recently developed technique, Optical Coherence Elastography (OCE) to quantitatively visualize kinetics of osmotic strains due to diffusive penetration of various osmotically active solutions into biologic...