Optical coherence tomography for noninvasive monitoring of drug delivery [0.03%]
用于非侵入性监测药物递送的光学相干断层扫描技术
Salavat Aglyamov,Kirill V Larin
Salavat Aglyamov
Optical Coherence Tomography (OCT) has revolutionized various medical imaging and diagnostics fields, offering unprecedented insights into the microstructural compositions of biological tissues. In recent years, OCT applications have been e...
Nanoparticles targeting the central circadian clock: Potential applications for neurological disorders [0.03%]
靶向中枢生物钟的纳米颗粒：在神经障碍中的潜在应用
Marion Le Meur,Jaime Pignatelli,Paolo Blasi et al.
Marion Le Meur et al.
Circadian rhythms and their involvement with various human diseases, including neurological disorders, have become an intense area of research for the development of new pharmacological treatments. The location of the circadian clock machin...
Targeting Tumor-Associated Microbiome: A New Aspect of Modulating Tumor Microenvironment for Cancer Therapy [0.03%]
靶向肿瘤相关微生物组：调控肿瘤微环境进行癌症治疗的新方面
Wantong Song,Leaf Huang
Wantong Song
3D printing in musculoskeletal interface engineering: Current progress and future directions [0.03%]
肌肉骨骼界面工程中的3D打印技术：现状与未来方向
Tianpeng Xu,Jingdong Rao,Yongyi Mo et al.
Tianpeng Xu et al.
The musculoskeletal system relies on critical tissue interfaces for its function; however, these interfaces are often compromised by injuries and diseases. Restoration of these interfaces is complex by nature which renders traditional treat...
Mayumi Hasegawa,Shinichi Kijima
Mayumi Hasegawa
In Japan, there has been a growing adoption of Model Informed Drug Development (MIDD) approaches as the rationale for optimal dose decision and modeling outputs have supported better characterizing the risk-benefit profile of a drug by acce...
Beyond the EPR effect: Intravital microscopy analysis of nanoparticle drug delivery to tumors [0.03%]
超越EPR效应：利用活体显微镜分析肿瘤的纳米颗粒药物传输过程
Iaroslav B Belyaev,Olga Yu Griaznova,Alexey V Yaremenko et al.
Iaroslav B Belyaev et al.
Delivery of nanoparticles (NPs) to solid tumors has long relied on enhanced permeability and retention (EPR) effect, involving permeation of NPs through a leaky vasculature with prolonged retention by reduced lymphatic drainage in tumor. Re...
Léa Guerassimoff,Stefaan C De Smedt,Félix Sauvage et al.
Léa Guerassimoff et al.
Acoustic tweezers are a highly promising technology for targeted drug delivery thanks to their unique capabilities: (i) they can effectively operate in both in vitro and in vivo environments, (ii) they can manipulate a wide range of particl...
Asmita Banstola,Zuan-Tao Lin,Yongli Li et al.
Asmita Banstola et al.
Light, a non-invasive tool integrated with cutting-edge nanotechnologies, has driven transformative advancements in imaging-based diagnosis and drug delivery for cancer and bacterial treatments. This review discusses recent progress in thes...
Recent advances in 3D bioprinted neural models: A systematic review on the applications to drug discovery [0.03%]
近期基于3D生物打印的神经模型在药物发现中的应用进展——系统综述
Amanda Orr,Farnoosh Kalantarnia,Shama Nazir et al.
Amanda Orr et al.
The design of neural tissue models with architectural and biochemical relevance to native tissues opens the way for the fundamental study and development of therapies for many disorders with limited treatment options. Here, we systematicall...
Additive manufacturing in spatial patterning for spinal cord injury treatment [0.03%]
用于脊髓损伤治疗的构建设备空间图案的加法制造技术
Christy Kwokdinata,Sing Yian Chew
Christy Kwokdinata
Combinatorial treatments integrating cells and biomolecules within scaffolds have been investigated to address the multifactorial nature of spinal cord injury (SCI). Current regenerative treatments have been ineffective as they do not consi...