Maximizing therapeutic potential and safety: Exploring multi/dual-payload antibody conjugates as cancer theranostics [0.03%]
最大化治疗潜力和安全性：探索抗体偶联多/双payload作为癌症诊疗药物
Meysam Khosravifarsani,Fabrice Ngoh Njotu,Dede Api Fon et al.
Meysam Khosravifarsani et al.
Tumor heterogeneity greatly contributes to the failure of traditional cancer treatments. This leads to tumor relapse, recurrence, and ultimately metastasis, presenting serious clinical challenges. In recent decades, advances in antibody-bas...
Nanomedicine for targeting brain Neurodegeneration: Critical barriers and circadian rhythm Considerations [0.03%]
靶向脑神经退行性疾病的纳米药物：关键障碍与昼夜节律考量
Laura Pineiro-Alonso,Inés Rubio-Prego,Alexandra Lobyntseva et al.
Laura Pineiro-Alonso et al.
The development of novel therapies for central nervous system (CNS) diseases, particularly neurodegenerative disorders like Alzheimer's disease (AD), is a critical global health priority. Biotherapeutics, such as monoclonal antibodies (mAbs...
William Parker,Amanda Taylor,Aryan Razdan et al.
William Parker et al.
Saccharomyces boulardii (Sb) is a Generally Regarded As Safe (GRAS) probiotic yeast currently used to alleviate symptoms from various gastrointestinal diseases. Sb is a promising platform for probiotic and biotherapeutic engineering as it i...
Advances in enhancing photoprotection of sunscreens using hydrocarbon film formers and carbon nanomaterials [0.03%]
利用烃类成膜剂和碳纳米材料改善防晒霜光防护性能的研究进展
Ajoa J Addae,Jennifer Uyanga,Joey Chifamba et al.
Ajoa J Addae et al.
Recent developments in sunscreen formulations have been made to enhance sunscreen films formed on the surface of the skin. Film formation is of particular interest for sunscreens because the ability of solubilized ultraviolet (UV) filters t...
Advances in photoactivated carbon-based nanostructured materials for targeted cancer therapy [0.03%]
光激活的基于碳的纳米结构材料在靶向癌症治疗中的新进展
Maryam Eftekharifar,Reza Heidari,Neda Mohaghegh et al.
Maryam Eftekharifar et al.
In this review, we explore key innovations in photoactivated therapeutic programming of carbon-based nanomaterials (CBNs), focusing on their diverse nanostructural configurations and their exceptional photothermal, photochemical, and photoa...
Advanced microbiome therapeutics for oral delivery of peptides and proteins: Advances, challenges, and opportunities [0.03%]
先进的微生物药物递送疗法用于肽和蛋白质的口腔给药：进展、挑战与机遇
Hitesh P Gelli,Ruben Vazquez-Uribe,Stephen T Buckley et al.
Hitesh P Gelli et al.
Peptide and protein medicines have changed the therapeutic landscape for many diseases, yet oral delivery remains a significant challenge due to enzymatic degradation, instability, and poor permeability in the gastrointestinal tract. Advanc...
Size-dependent penetration depth of colloidal nanoparticles into cell spheroids [0.03%]
尺寸依赖的胶体纳米粒子穿透进入细胞球体中的深度
Dingcheng Zhu,Dennis Brückner,Martin Sosniok et al.
Dingcheng Zhu et al.
The penetration of nanoparticle (NP)-based drugs into tissue is essential for their use as nanomedicines. Systematic studies about how different NP properties, such as size, influence NP penetration are helpful for the development of NP-bas...
Enhancing organoid technology with carbon-based nanomaterial biosensors: Advancements, challenges, and future directions [0.03%]
基于碳纳米材料生物传感器的类器官技术增强：进展、挑战与未来方向
Zahra Rezaei,Niyou Wang,Yipei Yang et al.
Zahra Rezaei et al.
Various carbon-based nanomaterials (CBNs) have been utilized to develop nano- and microscale biosensors that enable real-time and continuous monitoring of biochemical and biophysical changes in living biological systems. The integration of ...
Paving the way for bacteria-based drug delivery: biohybrid microrobots emerging from microrobotics and synthetic biology [0.03%]
基于细菌的药物递送生物杂交微机器人：来自微型机器技术和合成生物学的新方法
Elena Totter,Emilie von Einsiedel,Lisa Regazzoni et al.
Elena Totter et al.
Advances in microrobotics and synthetic biology are paving the way for innovative solutions to long-standing challenges in drug delivery. Both fields have independently worked on engineering bacteria as a therapeutic system, focusing on enh...
Enhancing the persistence of engineered biotherapeutics in the gut: Adhesion, glycan metabolism, and environmental resistance [0.03%]
增强工程生物治疗在肠道中的持久性：黏附、糖代谢和环境耐受性
Yujin Lee,Hyun Gi Koh,Kyoung Heon Kim et al.
Yujin Lee et al.
Engineered live biotherapeutic products (eLBPs) are receiving increasing attention as next-generation therapeutics to treat a variety of diseases with high specificity and effectiveness. Despite their potential, eLBPs face challenges, such ...