Editorial to "Hard-to-treat cancer: part II: drug delivery technologies and therapeutics strategies for pancreatic tumors, a hard-to-treat cancer" [0.03%]
难治性癌症的专论：第二部分——胰腺癌给药技术与治疗策略（针对难治性肿瘤）
África González-Fernández,Rosana Simón-Vázquez
África González-Fernández
High-dose subcutaneous Administration of Biologics: Overcoming barriers through formulation and device innovation [0.03%]
高剂量生物制剂皮下给药：通过制剂和设备创新克服障碍
Tarik A Khan,Deep Bhattacharya,Twinkle R Christian et al.
Tarik A Khan et al.
The therapeutic landscape for biologics is rapidly transitioning from intravenous (IV) to subcutaneous (SC) administration, offering significant benefits in cost reduction and patient convenience through enabling treatment in flexible care ...
High-dose biologics and bioconjugates delivery: Integrating molecular optimization with device design and routes of administration [0.03%]
高剂量生物制剂和生物缀合物的输送：结合分子优化与装置设计及给药途径
Naresh K Budhavaram,Kevin Harrison Duffy,Abraham H Abouzeid et al.
Naresh K Budhavaram et al.
In recent years, biologics-based modalities have increased significantly across various therapeutic areas. Monoclonal antibodies (mAbs) and emerging bioconjugates such as antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugat...
Advanced intelligent drug-device combination systems: regulatory landscapes, technological foundations, and clinical translation [0.03%]
先进的智能药物设备组合系统：监管格局、技术基础和临床转化
Zhengci Wang,Han Zhou,Ruixi Liao et al.
Zhengci Wang et al.
Drug-device combinations (DDCs) have evolved from simple drug-coated implants into sophisticated intelligent platforms capable of real-time sensing, adaptive drug delivery, and closed-loop therapeutic control. This transformation is driven ...
Near-infrared fluorescence imaging-guided targeted drug delivery in gastric tumors: From molecular design to clinical translation [0.03%]
近红外荧光影像引导胃肿瘤靶向药物递送研究：从分子设计到临床转化
Yuanyuan Ji,Nassuf Mourdi,Kai Bao et al.
Yuanyuan Ji et al.
Intraoperative image guidance has become a central component of modern surgical oncology, with near-infrared (NIR) fluorescence imaging emerging as a powerful platform for real-time visualization and precision intervention. Owing to its fav...
A glimpse into the future of model-informed drug discovery and development [0.03%]
模型指导的药物发现和开发的未来展望
Yu-Wei Lin,S Y Amy Cheung,Hak-Kim Chan et al.
Yu-Wei Lin et al.
Redox responsive nanosystems for medicine: from reactive species mapping to precision treatment [0.03%]
用于医学的氧化还原响应型纳米系统：从活性物种定位到精确治疗
Rui Sang,Biyao Yang,Kainat Zahra et al.
Rui Sang et al.
Redox dysregulation is a hallmark of numerous pathological conditions, including cancer, chronic inflammatory diseases, fibrosis, neurodegenerative disorders and cardiovascular diseases, where aberrant production of reactive oxygen, nitroge...
Microfluidics meets organoids: Kidney and bladder-on-Chip models for preclinical drug delivery assessment [0.03%]
微流控与类器官技术结合：肾和膀胱芯片模型在临床前药物递送评估中的应用
C Ma,D Koh,T Nishimura et al.
C Ma et al.
High clinical attrition rates in drug development are frequently driven by unforeseen drug-induced nephrotoxicity, a challenge exacerbated by the profound interspecies differences and limited predictivity of conventional animal models. This...
Overcoming intratumoral transport barriers: Advances in local immunotherapy delivery platforms [0.03%]
克服瘤内运输障碍：局部免疫治疗递送平台的最新进展
Madison A Deeson,Corrine Ying Xuan Chua,Alessandro Grattoni
Madison A Deeson
Cancer remains a leading cause of death worldwide, and current systemic therapies are limited by poor tumor penetration and retention, systemic toxicities, and therapeutic resistance. Intratumoral (IT) immunotherapy offers a promising alter...
Nanoscale metal-organic frameworks regulate redox homeostasis for Cancer therapy [0.03%]
纳米金属有机框架调节氧化还原平衡用于癌症治疗
Yuxuan Xiong,Wenbin Lin
Yuxuan Xiong
Redox metabolism plays a pivotal role in cancer initiation, progression, and resistance, making it an attractive target for intervention. Nanoscale metal-organic frameworks (MOFs) have emerged as versatile platforms for redox modulation owi...