Johann Gout,Menar Ekizce,Elodie Roger et al.
Johann Gout et al.
Pancreatic ductal adenocarcinoma (PDAC) is a lethal solid malignancy, rapidly progressing and highly therapeutic resistant, as reflected by its very low five-year overall survival. Despite significant advancements in our understanding of it...
Hemant Singh,Mahmood Razzaghi,Hamed Ghorbanpoor et al.
Hemant Singh et al.
Carbon dots (CDs) are recently introduced carbon nanomaterials showing diverse properties like unique fluorescent behavior, low cost, ecofriendliness, electron mobility, potent antioxidant, antibacterial capabilities, good biocompatibility,...
A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood-brain barrier permeation [0.03%]
大脑药物输送的新时代：结合多价性及计算优化以穿过血脑屏障
Giulia Porro,Marco Basile,Zhengdong Xie et al.
Giulia Porro et al.
Efficient drug delivery across the blood-brain barrier (BBB) remains a significant obstacle in treating central nervous system (CNS) disorders. This review provides an in-depth analysis of the structural and molecular mechanisms underlying ...
Harnessing epigenetic inhibitors: A promising approach for overcoming challenges in pancreatic ductal adenocarcinoma treatment [0.03%]
表观遗传学抑制剂在克服胰腺导管腺癌治疗难题中的应用前景
Immacolata Maietta,África González-Fernández,Rosana Simón-Vázquez
Immacolata Maietta
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and often fatal form of malignancy frequently diagnosed at an advanced stage, posing significant challenges for treatment. The complex and intricate microenvironment of PDAC, characte...
Aptamer-based applications in delivering cancer gene therapies and beyond: state of the art and the missing links to clinical translation [0.03%]
基于适配体的癌症基因治疗递送及其它方面的应用：现状与临床转化缺失环节分析
Gabriele Coppola,Fabiola Cennamo,Giuseppe Ciccone et al.
Gabriele Coppola et al.
The possibility of correcting genetic and epigenetic alterations through gene therapies has been considered a cornerstone in oncology. However, modest results have been achieved in clinics, mainly due to inefficient tumor targeting and side...
3D printed metamaterials: properties, fabrication, and drug delivery applications [0.03%]
三维打印超材料：性能、制造及药物传输应用
Hemant Singh,Muath Tuffaha,Shivi Tripathi et al.
Hemant Singh et al.
Drug delivery is a process to deliver the right amount of drug to the right place at the right time, while minimizing possible side effects and maximizing beneficial effectiveness. This is accomplished by drug delivery systems (DDSs), which...
CRISPR/Cas bioimaging: From whole body biodistribution to single-cell dynamics [0.03%]
基于CRISPR/Cas的生物成像：从整体水平示踪到单细胞动态监测
Ekaterina Kolesova,Sabina Pulone,Dmitry Kostyushev et al.
Ekaterina Kolesova et al.
This review explores the transformative role of CRISPR/Cas systems in optical bioimaging, emphasizing how advancements in nanoparticle (NP) technologies are revolutionizing the visualization of gene-editing processes both in vitro and in vi...
Polypharmacology approaches for brain disorders aimed to enhance brain permeability and circadian clock targeting [0.03%]
旨在增强脑渗透性和靶向生物钟的多药理学方法用于大脑疾病的治疗
Dionysis Kampasis,Elisa Uliassi,Maria Laura Bolognesi
Dionysis Kampasis
Circadian rhythm disruption (CRD) is a common feature of several brain disorders. The restoration of circadian clock function and the development of circadian-based therapies may have significant therapeutic implications for brain diseases ...
Corrigendum to "Light sheet fluorescence microscopy for monitoring drug delivery: unlocking the developmental phases of embryos" [Adv Drug Del. Rev. 218 (2025) 115520] [0.03%]
关于“用于监测药物输送的光片荧光显微镜：解锁胚胎发育阶段”一文的勘误（卷218，115520）
Gagan Raju,Aymeric Le Gratiet,Giuseppe Sancataldo et al.
Gagan Raju et al.
Published Erratum
Advanced drug delivery reviews. 2025 May 27:115609. DOI:10.1016/j.addr.2025.115609 2025
Dna-based nanostructures for tumor microenvironment-responsive drug delivery [0.03%]
基于DNA的纳米结构用于肿瘤微环境响应型药物递送
Siqi Li,Mengdi Xu,Chi Yao et al.
Siqi Li et al.
DNA nanostructures, with sequence programmability, biocompatibility, and structural versatility, have emerged as promising tools for biomedical applications, particularly in targeted drug delivery and therapeutic interventions. The tumor mi...