Antibody-drug conjugates as multimodal therapies against hard-to-treat cancers [0.03%]
抗体-药物偶联物作为治疗难治性癌症的多模式疗法
Georgina B Armstrong,Harriet Graham,Anthony Cheung et al.
Georgina B Armstrong et al.
Antibody-drug conjugates (ADCs) are rapidly emerging as an effective multimodal approach for the targeted delivery of cytotoxic small molecule to tumours with aberrantly overexpressed markers. Recent advances in antibody engineering and the...
Lights out for Superbugs: Is antimicrobial blue light a potential approach for future infection Control? [0.03%]
灭掉超级细菌：抗菌蓝光是未来感控的潜在手段吗？
Gizem D Ozdemir,Carolina Dos Anjos,Mehmet A Ozdemir et al.
Gizem D Ozdemir et al.
The rise of antimicrobial resistance (AMR) poses a significant threat to global health, as traditional antimicrobials are increasingly losing efficacy against a broad spectrum of pathogens. Antimicrobial blue light (aBL), an innovative ligh...
Harnessing carbon nanomaterials for reactive oxygen species regulation: Insights into generation, scavenging, and sensing [0.03%]
碳纳米材料在活性氧调节中的应用：生成、捕获和检测研究进展
Zhanpeng Jim Liu,Arpita Roy,Yuting Zheng et al.
Zhanpeng Jim Liu et al.
Carbon nanomaterials (CBNs) have driven significant research advances in medicine over the past decades due to their unique structures and properties. In particular, the role of CBNs in regulating reactive oxygen species (ROS) has been exte...
Navigating the complexities of pancreatic ductal adenocarcinoma: A review on therapeutic models and RAS inhibitors [0.03%]
胰腺导管腺癌的治疗模型及RAS抑制剂的研究进展综述
Sara Barrambana,Elena Zamorano-Domínguez,Vasiliki Liaki et al.
Sara Barrambana et al.
Pancreatic cancer is one of the most lethal types of cancer, known for a poor prognosis. Currently, the standard of care for unresectable tumors consists of combinations of cytotoxic chemotherapy. Thus far, targeted therapies against specif...
Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications [0.03%]
凝胶蛋白集成的碳纳米材料在纳米医学中的应用：从生物传感和生物打印到组织工程和其他生物医学应用
Mahdi Saeidirad,Nooshin Naderi,Saminalsadat Sehat et al.
Mahdi Saeidirad et al.
Carbon nanomaterials (CNMs) in combination with hydrogels (gelatin (Gel)) have shown significant potential in diagnostic and therapeutic applications. This study highlights their significant potential and explores their transformative role ...
Gut-brain-immune interactions: exploring probiotics as a drug delivery platform for neurological disease [0.03%]
肠道-大脑-免疫相互作用：探索益生菌作为神经疾病药物递送平台的可能性
Chinmayi R Gudi,Michael J Wannemuehler,Thomas J Mansell
Chinmayi R Gudi
The gut-brain-immune (GBI) axis, connecting gut microbes, neural tissue, and the cells of the immune system, plays a critical role in human health, particularly in relation to neurological diseases. Research in this field over the last few ...
Overcoming therapy resistance in pancreatic cancer: challenges and emerging strategies [0.03%]
克服胰腺癌治疗耐药性的挑战与新兴策略
Taymin du Toit-Thompson,Lionel Leck,Josef Gillson et al.
Taymin du Toit-Thompson et al.
Pancreatic cancer (PC) is one of the deadliest types of cancer, with a 5-year survival rate of ∼12.5 %. It is expected to become the second leading cause of cancer-related deaths by 2030. Despite recent advances in treatment options by adv...
From cell-SELEX to tissue-SELEX for targeted drug delivery and aptamer nanomedicine [0.03%]
从细胞SELEX到组织SELEX在靶向药物递送和适配体纳米医学中的应用
Ka-Ying Wong,Man-Sau Wong,Jung Heon Lee et al.
Ka-Ying Wong et al.
Aptamers are nucleic acid-based ligands that can selectively bind to target molecules. Because of their unique target-binding properties, the use of aptamers for targeting cell surface molecules has attracted broad research interest. The fi...
Mohammed Shahrudin Ibrahim,Abdul Rahim Ferhan,Chenchen Zhou et al.
Mohammed Shahrudin Ibrahim et al.
The rising demand for therapeutics, driven by aging populations and chronic diseases, challenges the pharmaceutical manufacturing of sustainable drug delivery systems. While development of microcarriers from natural sources such as plant or...
The Intersection of circadian rhythms and the blood-brain barrier with drug efficacy and delivery in neurological disorders [0.03%]
昼夜节律和血脑屏障与神经障碍的药物疗效和输送之间的交叉点关系研究
Kyra A Schindler,Silvia Torices,Nicolette Schurhoff et al.
Kyra A Schindler et al.
Circadian rhythms typically maintain a 24-hour cycle which determines the regulation of many genes and proteins including, but not limited to, those which control the permeability of the blood brain barrier (BBB). The BBB acts as a boundary...