Bioinspired approaches to encapsulate and deliver bacterial live biotherapeutic products [0.03%]
向细菌活生物治疗产品学习：包裹和递送细菌活生物治疗产品的方法
Noah Y Brittain,Joel A Finbloom
Noah Y Brittain
Bacteria-based therapies such as live biotherapeutic products (LBPs) allow for the in situ production of bioactive and therapeutic compounds, offering immense potential in the treatment of numerous diseases, including colitis, cancer, and m...
Predicting population dynamics of antimicrobial resistance using mechanistic modeling and machine learning [0.03%]
基于理论建模和机器学习预测抗菌药物的抗性人群动态变化
Zhengqing Zhou,Irida Shyti,Jaemin Kim et al.
Zhengqing Zhou et al.
Antimicrobial resistance (AMR) infections have become a global public health burden. The pipeline for new antibiotic discovery is draining due to the rapid emergence of resistance to new antibiotics, the limited economic return, and regulat...
Kelsey E Hern,Arthur Prindle
Kelsey E Hern
The known roles of human-associated microbes in health and disease have expanded in recent years. While the gut microbiome is the most well studied, the airway microbiome is gaining attention as an important gatekeeper of respiratory health...
Dandan Li,Huarui Liu,Xintong Li et al.
Dandan Li et al.
DNA, as a carrier of genetic information, has further been efficiently utilized as a foundational element in creating diverse nanostructures of different shapes and sizes through precise base pairing. With spatial addressability, structural...
Carbon dots as multi-modal contrast agents: opportunities and open challenges for in vivo bioimaging [0.03%]
碳点作为多功能对比剂：活体生物成像的机会与挑战
Elisa Sturabotti,Beatriz Sierra Serrano,Samantha Marcelino Apresto et al.
Elisa Sturabotti et al.
Carbon dots (CDs), a class of carbonaceous and fluorescent nanomaterials with ultra-small dimensions (below 10 nm), have become popular nanoparticles in several fields, such as nanomedicine, catalysis, sensing or electronics. Due to their c...
Advances in carbon nanomaterials and their polymeric composites in neural tissue engineering [0.03%]
用于神经组织工程的碳纳米材料及其聚合物复合材料的研究进展
Baishali Kanjilal,Prince David Okoro,Razieh Jaberi et al.
Baishali Kanjilal et al.
Carbon-based nanomaterials (CBMs) and their polymeric composites have garnered widespread interest in treating neurotrauma and neurodegenerative diseases, where restoring damaged central and peripheral nervous systems remains a persistent c...
Convection-enhanced delivery for brain malignancies: Technical parameters, formulation strategies and clinical perspectives [0.03%]
脑恶性肿瘤的对流增强递送：技术参数、配方策略和临床展望
Sara Jamshidi Parvar,Cheng In Wong,Andrew Lewis et al.
Sara Jamshidi Parvar et al.
The blood-brain barrier's protective nature greatly restricts the entrance of active pharmaceutical ingredients (APIs), presenting a significant challenge for effective drug delivery into the brain. Convection-enhanced delivery (CED) is eme...
Caenorhabditis elegans as an emerging high throughput chronotherapeutic drug screening platform for human neurodegenerative disorders [0.03%]
模式生物秀丽隐杆线虫成为人类神经退行性疾病药物筛选的新兴高效平台
Mrutyunjaya Panda,Maria Fakitsa,Maria Markaki et al.
Mrutyunjaya Panda et al.
An increase in the aging population is accompanied by increased susceptibility to age-associated neurodegeneration, with currently no cure. Despite the diversity of symptoms and etiologies, neurodegenerative disorders share mechanistic comm...
3D printing-enabled spatial patterning of biomimetic signals for bone tissue engineering [0.03%]
基于仿生信号的三维打印空间图案化技术在骨组织工程中的应用
Konstantinos Loukelis,Udayabhanu Jammalamadaka,Antonios G Mikos
Konstantinos Loukelis
Over the years, sustained research into the role of biomolecules in bone regeneration has provided valuable insights into their potential as therapeutic agents for tissue growth. However, challenges such as short half-lives and high product...
The molecular circadian clock: From fundamental mechanisms to therapeutic promise in neurological disorders [0.03%]
分子生物钟：从基本机制到神经疾病的治疗前景
Adam Campbell-Galland,Akanksha Bafna,Aarti Jagannath
Adam Campbell-Galland
Circadian rhythms are intrinsic biological processes in all forms of life, governed by a molecular clock, organising physiological and behavioural cycles to align with a 24-hour light-dark cycle. The disruption of these rhythms has been lin...