Stefana Duca,Sara Jamshidi Parvar,Luke Kumeta et al.
Stefana Duca et al.
Diffuse midline gliomas (DMGs) are a highly aggressive and inoperable type of paediatric brain tumours, with a median survival of less than one year. Therapeutic progress has been hindered by the tumour's anatomical location, its extensive ...
Toward pharmaceutical selective laser sintering 3D printing - a thermal and temperature-dependent analysis perspective [0.03%]
面向制药业的选择性激光烧结3D打印-热和温度依赖分析视角
Marta Łaszcz,Magdalena Urbanowicz,Ewelina Baran et al.
Marta Łaszcz et al.
The potential advantages of pharmaceutical additive manufacturing (AM) are thoroughly described in the literature. Challenges related to pharmaceutical AM are less discussed. Selective laser sintering (SLS) is one of the AM methods possible...
Tumor microenvironment subtyping in pancreatic ductal adenocarcinoma: New avenues for personalized therapeutic strategies [0.03%]
胰腺导管腺癌的肿瘤微环境分型：个性化治疗策略的新途径
Dharini Srinivasan,Johann Gout,Alexander Kleger et al.
Dharini Srinivasan et al.
In the past decade, single-cell-resolved approaches have uncovered the extensive heterogeneity of pancreatic ductal adenocarcinoma (PDAC), reshaping our understanding of this complex solid tumor. PDAC entities exhibit both intra- and inter-...
Sonodynamic therapy: transforming sound into light for hard-to-treat tumours [0.03%]
声动力疗法：将声波转化为光线治疗难治性肿瘤
Paul Cressey,Shazwan Bin Abd Shukor,Maya Thanou
Paul Cressey
Sonodynamic therapy (SDT) is an emerging therapeutic modality against hard-to-treat tumours. It involves the use of ultrasound (US) to excite sono-sensitive moieties to produce reactive oxygen species (ROS), which induce tumour cell death. ...
Egbe Vydaline Agbor Otu,Sergei Rozhkov,German Sosa et al.
Egbe Vydaline Agbor Otu et al.
Targeted drug delivery significantly enhances therapeutic efficacy across various diseases, particularly in cancer treatments, where conventional approaches such as chemotherapy and radiotherapy often cause severe side effects. In this cont...
Recent advances in intelligent oxygen delivery systems for tissue regeneration [0.03%]
用于组织再生的智能供氧系统最新研究进展
Xuehui Rui,Yiyang Jia,Ruochen Qiao et al.
Xuehui Rui et al.
Oxygen plays a critical regulatory role in tissue repair and regeneration. However, in the microenvironment of tissues with vascular damage, hypoxia is commonly present. This not only suppresses cell proliferation and differentiation but al...
Innovative engineering approaches to model host-microbiome interactions in vitro [0.03%]
创新工程方法在体外建模宿主-微生物组相互作用
Karen M Mancera Azamar,Samanvitha Deepthi Sudi,Zahra Mohammadalizadeh et al.
Karen M Mancera Azamar et al.
The human microbiome plays a critical role in health and disease. Disruptions in microbiota composition or function have been implicated not only as markers but also as drivers of diverse pathologies, creating opportunities for targeted mic...
Junru Li,Yongming Han,Na Chen et al.
Junru Li et al.
DNA exhibits remarkable versatility, which is attributed to its inherent molecular recognition capabilities, programmable sequences, and excellent biocompatibility. Among its various topological forms, branched DNA (bDNA), including Y-shape...
Chunfa Chen,Xiaoyu Xia,Cheng Tian et al.
Chunfa Chen et al.
DNA nanotechnology, a cutting-edge field that constructs sophisticated DNA-based nanostructures by harnessing the unparalleled programmability of DNA, has evolved into a powerful tool for applications in therapy, biosensing, logic computati...
Engineering in vivo behavior of DNA nanostructures toward organ-targeted drug delivery [0.03%]
工程在体内DNA纳米结构的行为定向器官药物输送
Jihoon Won,Seunghye Cho,Kyoung-Ran Kim et al.
Jihoon Won et al.
DNA nanostructures have emerged as programmable and biocompatible platforms for drug delivery, offering precise control over size, shape, and surface properties. Recent advances have demonstrated their potential for organ-targeted delivery ...