Yeonju Boo,Sang-Hun Choi,Jihoon Kim et al.
Yeonju Boo et al.
Nitric oxide (NO) plays dual and context-dependent roles in the immune system, functioning as either an immunostimulatory or immunosuppressive mediator depending on its concentration, cellular source, and exposure dynamics. Dysregulated end...
Opportunities for machine learning and artificial intelligence in physiologically-based pharmacokinetic (PBPK) modeling [0.03%]
基于生理的药代动力学(PBPK)模型中机器学习和人工智能的应用机遇
Anne M Talkington,Yanguang Cao,Anthony J Kearsley et al.
Anne M Talkington et al.
Physiologically-based pharmacokinetic (PBPK) modeling is a powerful tool for quantitating and understanding the fate of drug and drug carriers in complex living systems. It is particularly valuable in situations where data are difficult to ...
Advancements in 3D-printing strategies towards developing effective implantable drug delivery systems: Recent applications and opportunities [0.03%]
面向有效植入药物输送系统的3D打印策略进展：近期应用与机遇
Kieran Lau,Hien A Tran,Renjian Tan et al.
Kieran Lau et al.
The development of implantable drug delivery systems has played a transformative role in modern medicine through enabling more precise, localized and sustained delivery of therapeutics. This has advantages over systemic delivery routes that...
A M van der Does,L V Schledorn,R Olmer
A M van der Does
Chronic lung diseases (CLD), including chronic obstructive pulmonary disease (COPD), pulmonary fibrosis and pulmonary hypertension, represent a significant health burden worldwide and their incidence is steadily increasing. Specifically, CO...
Shaobo Yang,Mengdi Yang,Maria Jennings et al.
Shaobo Yang et al.
Bacteria have emerged as versatile platforms for therapeutic delivery, owing to their inherent adaptability, genetic tractability, and ability to interface with the human microbiome and immune system. This review explores the evolution of b...
Recent advances in gene delivery for melanocyte-associated disorders [0.03%]
近期基因传递在黑色素细胞相关疾病治疗中的新进展
Tanya Chhibber,Dekker C Deacon,Hamidreza Ghandehari et al.
Tanya Chhibber et al.
Melanocytes are cells present at the epidermal-dermal junction of the skin that produce pigment melanin, which provides color to the skin, eyes, and hair. Dysregulation in melanocyte function, viability, or differentiation can result in mel...
20 years of flash nanoprecipitation - from controlled precipitation to global medicine [0.03%]
闪纳米沉淀技术诞生二十周年——从可控沉淀到全球医药
Kurt D Ristroph,Nathalie M Pinkerton,Chester E Markwalter et al.
Kurt D Ristroph et al.
In the twenty years since the development of Flash NanoPrecipitation (FNP) technology, an antisolvent precipitation technique that uses rapid turbulent mixing to drive self-assembly of polymeric or lipid nanoparticles, the platform has been...
Glioblastoma and blood-brain barrier cell interplay in vitro models for stratification of drug efficacy [0.03%]
体外模型中胶质母细胞瘤与血脑屏障细胞的相互作用用于药物疗效分类
Cecília Ferreira,Bruno Sarmento,Cláudia Martins
Cecília Ferreira
Glioblastoma (GBM) is the most lethal brain cancer in adults, with a dismal prognosis and no curative therapies available. The treatment landscape remains largely stagnant, relying on tumor resection, temozolomide (TMZ) chemotherapy, and ra...
Optical technologies in monitoring mobility and delivery of drugs and metabolic agents [0.03%]
光学技术在监控药物及代谢载体输送方面的应用
Valery V Tuchin,Tianhong Dai,Luís M Oliveira
Valery V Tuchin
Yingying Li,Tatiana N Zamay,Natalia A Luzan et al.
Yingying Li et al.
Cancer treatment has transitioned from traditional chemotherapy to the molecular medicine era, emphasizing personalized therapy at the molecular level. Aptamers, also known as 'chemical antibodies', play a pivotal role in advancing molecula...