Italo Rodrigo Calori,Ana Paula Pereira Guimaraes,Antonio Claudio Tedesco
Italo Rodrigo Calori
Additive manufacturing has transformed traditional methods to fabricate theranostic, allowing the production of more complex devices that address evolving diagnostic and therapeutic demands. In this context, three-dimensional (3D) printing ...
Advanced adhesion and targeting strategies to prolong gut residence time and improve eLBP efficacy in colonic diseases [0.03%]
先进的黏附和靶向策略延长肠道驻留时间以改善结肠疾病中的口服低剂量给药疗效
Alita Miller,Sri Sruthi Potluru,Sarah Thormann et al.
Alita Miller et al.
Engineered live biotherapeutic products (eLBPs) are genetically modified microorganisms being explored as a novel treatment modality for gastrointestinal (GI) diseases. The therapeutic potential is driven by their ability to selectively int...
Investigating the restriction-modification barrier to DNA delivery in human gut probiotic bacteria for streamlined genetic tool development [0.03%]
探究人类肠道益生菌细菌中DNA传递的限制修饰屏障以实现遗传工具开发的简化流程
Qiaochu Li,Ibrahim Al&#x; Abri,Nathan Crook et al.
Qiaochu Li et al.
Human gut bacteria have the potential to serve as next-generation therapeutics to many disease conditions, although poor genetic tractability limits mechanistic understanding and engineering capabilities in most strains. A major barrier to ...
The complex and intricate relationship between incremental science, innovation and recognition [0.03%]
增量科学、创新和认可之间的复杂关系
Charlotte A Birkmanis,David W Grainger,Dietmar W Hutmacher
Charlotte A Birkmanis
Science, technology, and innovation are related but distinct, leading to different research incentives. Incremental science, such as refining methods and validating findings, ensures robust results and understanding, laying the groundwork f...
Hydrogen sulfide in cancer therapy: Intelligent delivery platforms and synergistic therapeutic paradigms [0.03%]
癌症治疗中的硫化氢：智能递送平台和协同治疗模式
Nailin Yang,Yichi Cai,Shumin Sun et al.
Nailin Yang et al.
Hydrogen sulfide (H2S) has emerged as a pivotal gaseous signaling molecule in cancer therapy, demonstrating unique dose-dependent therapeutic effects that have established new paradigms for gas-mediated treatments. To enable precise H2S del...
Microbiome-active drug delivery systems (MADDS): Leveraging microbial stimuli for controlled drug release [0.03%]
基于微生物刺激的药物递送系统(MADDS)：用于控制药物释放
Srinivas Kamath,Amin Ariaee,Amer Abdelhafez et al.
Srinivas Kamath et al.
The human microbiome comprises diverse microbial communities that inhabit tissues and biofluids throughout the body, including the gastrointestinal tract, lungs, vagina, and skin. These sites create dynamic microenvironments rich in enzymes...
Composition, stabilization and delivery of virus-based vaccines: considerations to break free of the cold chain [0.03%]
基于病毒的疫苗的组成、稳定和输送：打破冷链限制的考虑因素
Amaka J Epoh,Jailen H Doyle,Irnela Bajrovic et al.
Amaka J Epoh et al.
Within the last 50 years, the emergence and re-emergence of widespread severe viral infections have caused some of the deadliest global pandemics. Thus, development of novel technologies that effectively stabilize and deliver virus-based va...
iPSC-derived T cells and macrophages: Manufacturing and next-generation application approaches [0.03%]
基于 iPSC 的 T 细胞和巨噬细胞：制造及下一代应用方法
Débora Basílio-Queirós,Isabelle Rivière,Sjoukje J C van der Stegen et al.
Débora Basílio-Queirós et al.
Chimeric antigen receptor (CAR) technology has transformed the immunotherapy field with significant success in the treatment of hematological diseases. Nonetheless, challenges in scalability, donor variability as well as in the treatment of...
Cold atmospheric plasma for gas therapy and gas-activated drug delivery [0.03%]
冷等离子体气体治疗及活化给药体系研究进展
Qiaoyun Li,Jaehyun Choi,Namjo Shin et al.
Qiaoyun Li et al.
Cold atmospheric plasma (CAP) has emerged as a promising tool for in situ gas delivery due to its ability to generate reactive oxygen and nitrogen species, which play a crucial role in oxidative stress-mediated therapeutic effects. As the f...
Paediatric formulation challenges for enteral feeding tube administration - Current understanding and future directions [0.03%]
肠饲管给药的儿科剂型挑战：当前认识与未来方向
Sifan Hu,Noelia Nieto González,Jennifer Walsh et al.
Sifan Hu et al.
Enteral administration of oral dosage forms is a highly desirable treatment approach for children having impaired swallowing ability or limited gastro-intestinal access. However, the complex interplay between drug formulation and enteral fe...