Implications of genetic and epigenetic aberrations to the tumorigenicity of human pluripotent stem cells [0.03%]
遗传和表观遗传异常对人类多能干细胞致癌性的影响
Gal Keshet,Ivana Barbaric,Nissim Benvenisty
Gal Keshet
Human pluripotent stem cells (hPSCs) hold immense promise for cell replacement therapies due to their capacity to give rise to derivatives of the three embryonic germ layers and their ability to divide indefinitely in culture. Since their f...
Microbial heterogeneity-mediated treatment evasion and the potential for engineered live biotherapeutic products [0.03%]
微生物异质性介导的治疗逃避及工程化活体生物药物的潜在应用
Eli G Cytrynbaum,Megan N McClean
Eli G Cytrynbaum
Microbial populations exhibit both genetic and non-genetic heterogeneity. In the clinical context, this heterogeneity is of concern as it provides subsets of microbial populations with enhanced immune evasion abilities and antimicrobial res...
Guiding design and performance of nonviral nucleic acid delivery vehicles via machine learning [0.03%]
基于机器学习的非病毒核酸递送载体的设计、性能研究及展望
John A Hutchinson,Sidharth Panda,Plinio D Rosales et al.
John A Hutchinson et al.
Machine Learning (ML) techniques have enabled the advancement of many technologies throughout the pharmaceutical industry, especially for drug discovery. One of the most rapidly growing technologies within the pharmaceutical space is gene t...
Advanced oral therapies for colorectal cancer via nanomedicine and microbiota modulation [0.03%]
纳米医学和微生态调节在结直肠癌口服用药中的应用
Yu Wang,Cheng Chen,Xin Xiao et al.
Yu Wang et al.
Colorectal cancer (CRC) is the third most common malignancy and the second most lethal cancer worldwide and has become a significant burden on global healthcare. The primary treatments for CRC include surgery, chemotherapy, and targeted the...
Red to near-infrared carbon dots: synthesis, cellular interactions, drug loading, and therapeutic applications [0.03%]
从红色到近红外碳点的合成、细胞作用、药物负载及治疗应用
Pooria Lesani,Iman Zare,Mansi Khetarpaul et al.
Pooria Lesani et al.
The emergence of nanoparticles (NPs) has profoundly revolutionized targeted drug delivery systems, overcoming numerous limitations associated with conventional therapies. Red to near-infrared (NIR) emissive carbon dots (RNCDs) have emerged ...
Informing development of brain cancer therapies within "preclinical trials" using ex vivo patient tumors [0.03%]
利用“临床前试验”外植体患者肿瘤推动脑癌治疗发展
Adebimpe Adefolaju,David E Kram,Breanna Mann et al.
Adebimpe Adefolaju et al.
Brain and nervous system cancers account for only ~1.3% of new cancer diagnoses but rank ninth in US cancer mortality, a disparity partly driven by limited therapeutic options and inadequate preclinical models that misrepresent a drug's the...
Polymer-based nanomedicines: Supporting multimodal approaches to glioblastoma Multiforme treatment [0.03%]
聚合物基纳米药物：支持多模式治疗胶质母细胞瘤的方法
Amina Benaicha-Fernández,Stuart P Atkinson,Inmaculada Conejos-Sánchez et al.
Amina Benaicha-Fernández et al.
Glioblastoma multiforme (GBM) remains one of the most aggressive and lethal cancers affecting the central nervous system (CNS), with significant obstacles precluding effective diagnosis, treatment, and monitoring, including the presence of ...
Spatial patterning strategies for liver tissue engineering: Biofabrication technologies and applications [0.03%]
肝组织工程技术的空间图案策略：生物制造技术和应用
Haram Nah,Ashlin R Michell,Kerry M Rogy et al.
Haram Nah et al.
The liver is composed of hepatocytes and non-parenchymal cells arranged in precise spatial patterns that enable more than 500 metabolic, synthetic, and detoxification functions. Replicating this hierarchical structure and dynamic multicellu...
Pei Pan,Tao Liu,Lu Zhang et al.
Pei Pan et al.
The clinical translation of gas therapy, which employs medical gases such as nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H2S), hydrogen (H2), and sulfur dioxide (SO2), is mainly limited by the absence of delivery systems that...
Lam-Duc-Huy Nguyen,Sheng-Yao Peng,Cam-Hoa Mac et al.
Lam-Duc-Huy Nguyen et al.
Molecular hydrogen (H2) has emerged as a promising therapeutic agent owing to its selective antioxidant and anti-inflammatory properties, as well as its ability to modulate cellular signaling, metabolism, and immune responses. Beyond mitiga...