Recent advances in numerical simulation of magnetically guided drug delivery systems and applications [0.03%]
磁控药物传输系统数值模拟研究进展及应用实例
Zhenyang Xu,Tayebeh Mousavi,Xiaoli Liu et al.
Zhenyang Xu et al.
Magnetically guided drug delivery (MGDD) employs magnetic forces acting on magnetically responsive drug delivery systems (DDS) to direct therapeutic agents toward diseased regions, thereby enhancing local drug accumulation while minimising ...
Perspectives and trends in gas delivery systems based on ultrasound responsive nanomaterials for cancer therapy [0.03%]
基于超声响应纳米材料的癌症治疗供气系统的新进展及未来趋势
Jooho Moon,Hanhee Cho,Jeonghun Yu et al.
Jooho Moon et al.
Gas-based therapeutic strategies (e.g., nitric oxide and carbon dioxide delivery) have shown promising potential for modulating the tumor microenvironment and enhancing anticancer efficacy. However, their clinical translation is limited by ...
GMP-compliant manufacturing of iPSC-derived therapeutic cell products: Technologies, applications, risks and limitations [0.03%]
符合GMP规范的诱导多能干细胞来源治疗性细胞产品的生产工艺：技术、应用、风险及局限性
Alexandra Haase,Arjang Ruhparwar,Ulrich Martin
Alexandra Haase
The development of induced pluripotent stem cells (iPSCs) has transformed the field of regenerative medicine. However, to use iPSCs for therapeutic applications, iPSC-based products must be produced under Good Manufacturing Practice (GMP) c...
Implications of genetic and epigenetic aberrations to the tumorigenicity of human pluripotent stem cells [0.03%]
遗传和表观遗传异常对人类多能干细胞致癌性的影响
Gal Keshet,Ivana Barbaric,Nissim Benvenisty
Gal Keshet
Human pluripotent stem cells (hPSCs) hold immense promise for cell replacement therapies due to their capacity to give rise to derivatives of the three embryonic germ layers and their ability to divide indefinitely in culture. Since their f...
Microbial heterogeneity-mediated treatment evasion and the potential for engineered live biotherapeutic products [0.03%]
微生物异质性介导的治疗逃避及工程化活体生物药物的潜在应用
Eli G Cytrynbaum,Megan N McClean
Eli G Cytrynbaum
Microbial populations exhibit both genetic and non-genetic heterogeneity. In the clinical context, this heterogeneity is of concern as it provides subsets of microbial populations with enhanced immune evasion abilities and antimicrobial res...
Guiding design and performance of nonviral nucleic acid delivery vehicles via machine learning [0.03%]
基于机器学习的非病毒核酸递送载体的设计、性能研究及展望
John A Hutchinson,Sidharth Panda,Plinio D Rosales et al.
John A Hutchinson et al.
Machine Learning (ML) techniques have enabled the advancement of many technologies throughout the pharmaceutical industry, especially for drug discovery. One of the most rapidly growing technologies within the pharmaceutical space is gene t...
Advanced oral therapies for colorectal cancer via nanomedicine and microbiota modulation [0.03%]
纳米医学和微生态调节在结直肠癌口服用药中的应用
Yu Wang,Cheng Chen,Xin Xiao et al.
Yu Wang et al.
Colorectal cancer (CRC) is the third most common malignancy and the second most lethal cancer worldwide and has become a significant burden on global healthcare. The primary treatments for CRC include surgery, chemotherapy, and targeted the...
Red to near-infrared carbon dots: synthesis, cellular interactions, drug loading, and therapeutic applications [0.03%]
从红色到近红外碳点的合成、细胞作用、药物负载及治疗应用
Pooria Lesani,Iman Zare,Mansi Khetarpaul et al.
Pooria Lesani et al.
The emergence of nanoparticles (NPs) has profoundly revolutionized targeted drug delivery systems, overcoming numerous limitations associated with conventional therapies. Red to near-infrared (NIR) emissive carbon dots (RNCDs) have emerged ...
Informing development of brain cancer therapies within "preclinical trials" using ex vivo patient tumors [0.03%]
利用“临床前试验”外植体患者肿瘤推动脑癌治疗发展
Adebimpe Adefolaju,David E Kram,Breanna Mann et al.
Adebimpe Adefolaju et al.
Brain and nervous system cancers account for only ~1.3% of new cancer diagnoses but rank ninth in US cancer mortality, a disparity partly driven by limited therapeutic options and inadequate preclinical models that misrepresent a drug's the...
Polymer-based nanomedicines: Supporting multimodal approaches to glioblastoma Multiforme treatment [0.03%]
聚合物基纳米药物：支持多模式治疗胶质母细胞瘤的方法
Amina Benaicha-Fernández,Stuart P Atkinson,Inmaculada Conejos-Sánchez et al.
Amina Benaicha-Fernández et al.
Glioblastoma multiforme (GBM) remains one of the most aggressive and lethal cancers affecting the central nervous system (CNS), with significant obstacles precluding effective diagnosis, treatment, and monitoring, including the presence of ...