Microphysiological ("organ-on-a-chip") models of pulmonary infections for developing novel anti-infectives [0.03%]
肺部感染的微生理学（“芯片上的器官”)模型在开发新型抗感染药物中的应用
Anne Rindchen,Nicole Schneider-Daum,Claus-Michael Lehr
Anne Rindchen
Infectious diseases are among the leading death causes globally, with the lung being particularly vulnerable due to its continuous exposure to inhaled pathogens. Yet, anti-infective research and drug development are hampered by the lack of ...
Yunching Chen,Lorenz Meinel,Hyuncheol Kim
Yunching Chen
Pharmacokinetic modeling and quantitative prediction of subcutaneous absorption of antibody-based therapeutics - An update [0.03%]
抗体药物治疗的皮下吸收药代动力学模型及定量预测研究进展
Anna Siemiątkowska,Celine Park,Leonid Kagan
Anna Siemiątkowska
A significant advancement has been made in recent years in understanding subcutaneous (SC) absorption of biologics. Still, the accurate prediction of human SC absorption of antibody-based therapeutics remains an unmet need. A review article...
Garrett F Beeghly,Amid Shakeri,Fatemeh Mirzapour-Shafiyi et al.
Garrett F Beeghly et al.
The precise spatial organization of the heart across molecular, cellular, and tissue length scales underpins cardiac function. Recreating this architecture in engineered heart tissues remains a central challenge, as cardiac morphogenesis in...
From implantable to wearable: recent advances in microfluidic platforms for precision drug delivery [0.03%]
从植入式到可穿戴式：精密药物输送微流体平台的最新进展
Fatma Moawad,Shihao Pei,Alfonso Nieto-Argüello et al.
Fatma Moawad et al.
Wearable and implantable microfluidic drug delivery systems have emerged as promising platforms that address key limitations of conventional systems, including poor dosing control, variable bioavailability, and systemic toxicities. By enabl...
Lexie W Q Xi,Zhuojian Look,Clemence Bonnet et al.
Lexie W Q Xi et al.
The key characteristics of the cornea, its transparency and avascularity, emerge from spatial organization of cell populations, extracellular matrix layers, biomechanical properties, and morphogenic cues. This review translates these organi...
Scalable process technologies for human pluripotent stem cells (hPSCs) expansion and differentiation [0.03%]
人多能干细胞(hPSCs)的体外扩增与分化培养工艺开发技术scalable process technologies for human pluripotent stem cells (hPSCs) expansion and differentiation
Kevin Cyrys,Robert Zweigerdt
Kevin Cyrys
Human pluripotent stem cells (hPSCs) can serve as an unlimited, renewable "raw material" for essentially any therapeutic cell product, placing them at an exciting intersection of biology, manufacturing and the emerging field of regenerative...
Toward bioengineered muscle-fat microphysiological systems for sports medicine and obesity therapeutics [0.03%]
用于运动医学和肥胖症治疗的肌肉脂肪微生理系统生物工程技术研究方向
Min Young Kim,Anicca D Harriot,Deok-Ho Kim
Min Young Kim
Muscle injuries represent a major healthcare burden, yet we lack platforms capable of predicting human responses to exercise, injury, and therapeutic interventions. Muscle-on-chip (MoC) technologies can now reproduce physiological force gen...
Xuanbo Zhang,Changrong Shi,Pei Huang et al.
Xuanbo Zhang et al.
Redox imbalance is a defining feature of the tumor microenvironment (TME). Tumor cells adapt to this oxidative pressure through robust antioxidant pathways, whereas immune cells are easily impaired, leading to poor antigen presentation, com...
Cowpea mosaic virus as a candidate for intratumoral immunotherapy: progress, challenges, and future directions [0.03%]
豇豆花叶病毒作为瘤内免疫治疗候选物：进展、挑战和未来方向
Ayumi E Pottenger,Anthony O Omole,Nicole F Steinmetz
Ayumi E Pottenger
Immunotherapy has emerged as a new pillar of cancer therapeutics that utilizes the patient's own immune system to target tumor cells, a particular advantage in the context of hard-to-treat cancers. Virus-based immunotherapies have shown gre...