Serum cell-free mitochondrial DNA under a highly standardized and controlled stress induction [0.03%]
高度标准化和可控应激诱导下的血清游离线粒体DNA
Benedict Herhaus,Carina Daubermann,Elmo W I Neuberger et al.
Benedict Herhaus et al.
Cell-free mitochondrial DNA (ccf-mtDNA) is increasingly recognized as a biomarker of stress-related mitochondrial dysfunction. Acute psychological stress may induce ccf-mtDNA release, underscoring its potential role in stress physiology and...
Transcriptional activation by MNRR1 is effected by recruiting p300 and can be induced by minimal peptides [0.03%]
MNRR1通过募集p300激活转录并可被最小的多肽诱导
Neeraja Purandare,Vignesh Pasupathi,Deepesh Padhan et al.
Neeraja Purandare et al.
Mitochondrial Nuclear Retrograde Regulator 1 (MNRR1; also, CHCHD2, PARK22, AAG10), which functions in both the mitochondria and the nucleus, modulates mitochondrial function as well as cellular stress response. We have previously shown that...
PP2A inhibition alleviates DCD liver damage during prolonged cold ischemia by interfering Drp1 translocation and ER stress [0.03%]
PP2A抑制通过干扰Drp1易位和ER应激缓解DCD肝延长冷缺血损伤
Jianan Lan,Zhongshan Lu,Quanwei Cheng et al.
Jianan Lan et al.
Prolonged cold ischemia-warm reperfusion (PCI/WR) of donor livers is an independent risk factor for primary nonfunction (PNF) after liver transplantation (LT). Previous studies have demonstrated that may be related to hepatocyte apoptosis m...
Mitochondria transfer from myocytes to endothelial cells Promotes angiogenesis in skeletal muscle [0.03%]
线粒体从肌细胞转移到内皮细胞促进骨骼肌的血管生成
Yu-Feng Long,Ai-Jun Huang,Shuo Tang et al.
Yu-Feng Long et al.
Skeletal muscle and vascular health are closely interconnected, yet the mechanisms underlying their crosstalk remain poorly understood. This study investigates the role of mitochondria transfer from myocytes to endothelial cells. Using in v...
Sensitivity of primary mitochondrial disease fibroblasts to ferroptosis: The role of intracellular iron [0.03%]
原发性线粒体病成纤维细胞对铁死亡的敏感性：胞内铁的作用
Svetlana Pecheritsyna,Melisa Emel Ermert,Emina Podhumljak et al.
Svetlana Pecheritsyna et al.
Primary mitochondrial diseases (PMDs) are directly linked to oxidative phosphorylation (OXPHOS) dysfunction. Here, we investigated the selective sensitivity of PMD patient fibroblasts compared to healthy control primary human skin fibroblas...
Biallelic FOXRED1 mutations cause infantile mitochondrial encephalopathy with complex I disassembly and basal ganglia degeneration [0.03%]
FOXRED1双等位基因突变导致婴儿线粒体脑病、复杂I型解聚及基底节退行性病变
Cunhui Pan,Ruowei Zhu,Xi Huang et al.
Cunhui Pan et al.
Developmental and epileptic encephalopathy (DEE) is a severe neurological disorder. Biallelic mutations in the nuclear-encoded mitochondrial chaperone gene FOXRED1, a specific assembly factor for complex I, cause mitochondrial dysfunction; ...
Aagab-driven SHIP2 degradation rescues mitochondrial dysfunction in hypoxic-ischemic encephalopathy [0.03%]
溶血磷脂A磷酸酶驱动的SHIP2降解可修复缺氧缺血性脑病患者的线粒体功能损伤
Jinli Han,Lu He,Ling Chen et al.
Jinli Han et al.
Neonatal hypoxic-ischemic encephalopathy (HIE), a central nervous system disorder caused by oxygen deprivation and reduced cerebral blood flow, involves complex mechanisms including mitochondrial oxidative stress and neuronal injury. The Ra...
Stress at the gates: Mitochondrial import dysfunctions, response pathways, and therapeutic potential [0.03%]
线粒体蛋白导入障碍、响应通路及潜在的治疗方式：压力在大门处累积
Hélène Calais,Giulia Bertolin
Hélène Calais
Mitochondrial protein import is necessary to ensure the proper functioning of the organelle of the cell as a whole. More than 1000 proteins are synthesized on cytosolic ribosomes and then imported into mitochondria through translocases such...
Dysregulation of RUNX1 isoforms drives mitochondrial defects during neural differentiation in down syndrome [0.03%]
Down综合征神经分化过程中RUNX1异构体的失调导致线粒体缺陷
Yan-Na Liu,Qin Cai,Ke-Yi Li et al.
Yan-Na Liu et al.
Down syndrome (DS) is distinguished by neurodevelopmental abnormalities, with mitochondrial dysfunction. The Runt-related transcription factor 1 (RUNX1) gene, located within the Down Syndrome Critical Region (DSCR), is known to encode three...
The mitochondrial protein TMEM177 fine-tunes mammalian cytochrome c oxidase assembly [0.03%]
线粒体蛋白TMEM177调节哺乳动物细胞色素c氧化酶的组装
Jakob D Busch,Thomas Schöndorf,Dusanka Milenkovic et al.
Jakob D Busch et al.
The mitochondrial cytochrome c oxidase (COX, complex IV), a multi-subunit protein complex, plays a crucial role in cellular respiration by reducing oxygen to water and simultaneously pumping protons to enable oxidative phosphorylation (OXPH...