Role of oxidative stress in the susceptibility to mitophagy of the skin fibroblasts and iPSC-derived neurons of patients with MERRF syndrome [0.03%]
线粒体DNA突变引起的MERRF综合征患者皮肤纤维母细胞和iPSC来源神经元发生自噬的氧化应激机制研究
Yu-Ting Wu,Hui-Yi Tay,Hsiao-Hui Liao et al.
Yu-Ting Wu et al.
Myoclonic epilepsy with ragged-red fibers (MERRF) syndrome is mainly caused by the m.8344A > G mutation and mitochondrial dysfunction, but the pathogenesis remains unclear. In this study, we demonstrated that carbonyl cyanide m-chlorophenyl...
Challenging mtDNA tRNA variant guidelines: Emphasizing single-cell analysis through four novel variants [0.03%]
挑战线粒体tRNA变异指南：通过四个新型变异强调单细胞分析的重要性
Prosper Chloé,Zereg Elamine,Chaussenot Annabelle et al.
Prosper Chloé et al.
The broad clinical and genetic heterogeneity of mitochondrial diseases makes diagnosis challenging. Accurate characterization of novel variants is crucial to reduce diagnostic uncertainty, guide treatment, and enable reliable genetic counse...
Electron microscopy visualization of cell-free mitochondrial DNA-associated vesicular structures in human plasma, serum, and saliva [0.03%]
人血浆、血液和唾液中无细胞线粒体DNA相关囊泡结构的电子显微镜可视化技术
Alexandra Volos,Soah Grace Franklin,Jeremy Michelson et al.
Alexandra Volos et al.
Human biofluids contain cell-free mitochondrial DNA (cf-mtDNA) and extracellular mitochondria (ex-Mito), creating the challenge of defining their origins, destinations, mechanisms of regulation, and purposes. To expand our understanding of ...
m6A-Mediated epitranscriptomic control of mitochondrial dysfunction in neurodegeneration [0.03%]
神经退行性疾病中通过m６Ａ介导的表转录组学调控线粒体功能障碍
Abhishek Jauhari
Abhishek Jauhari
Mitochondrial dysfunction is a common pathology of neurodegenerative diseases, which contributes to neuronal vulnerability via excessive oxidative stress, impaired bioenergetics, and dysregulated apoptosis. Emerging studies highlighted the ...
Discovery of FRAG-i: a small molecule inhibitor of Drp1 that modulates mitochondrial fission [0.03%]
线粒体分裂调节剂FRAG-i的发现及其作为Drp1抑制剂的作用
Şeyma Ateşoğlu,Sude Naz Çataltepe,Esra Bardakcı et al.
Şeyma Ateşoğlu et al.
Mitochondrial dynamics, regulated by the balance of fission and fusion, are essential for cellular homeostasis, and their disruption-particularly via excessive Drp1-dependent fission-contributes to cancer and other pathologies. Current Drp1...
A century of studies on mitochondrial cytochrome c oxidase [0.03%]
线粒体细胞色素c氧化酶的研究历程回顾——过去百年中的重要发现与未来问题
Ulrik Pedroza-Dávila,Yolanda Camacho-Villasana,Diego González-Halphen et al.
Ulrik Pedroza-Dávila et al.
Cytochrome c oxidase (CcO, complex IV) is the last component of the respiratory chain, catalyzing the reduction of oxygen to water and the translocation of protons to the inner membrane space. In 1925, David Keilin published his work on the...
Insights into mitochondrial-mediated immune responses in Galleria mellonella: A model for fungal pathogenesis and redox regulation [0.03%]
愈创木菌介导的免疫反应的新见解：一种真菌病原学和红氧调节的模型研究
Kaczmarek Agata,Boguś Mieczysława Irena
Kaczmarek Agata
Innate immunity's integration of redox signaling in pathogen defense is a key area in host-pathogen biology. Using Galleria mellonella infected with the fungus Conidiobolus coronatus, we reveal mitochondrial redox-mediated immune responses....
Quantitative proteomic profiling of neural cells-specific metabolic reprogramming in response to mitochondrial dysfunction using iMPAQT2 [0.03%]
利用iMPAQT2对线粒体功能障碍反应的神经元细胞特异性代谢重编程进行定量蛋白质组学分析
Akito Tani,Mikako Yagi,Natsuki Horiuchi et al.
Akito Tani et al.
Age-related mitochondrial dysfunction is increasingly recognized as a key contributor to neurodegenerative disease pathogenesis. In the central nervous system, neurons, oligodendrocytes, and astrocytes which derived from neural stem cells, ...
Predicting recurrence risk of leigh syndrome using prenatal mtDNA heteroplasmy assessment [0.03%]
利用产前mtDNA杂合性评估预测莱格威氏症复发风险
Maria Shishimorova,Hong Ma,Amy Koski et al.
Maria Shishimorova et al.
Predicting recurrence risk for mitochondrial DNA (mtDNA) disorders is challenging because heteroplasmy levels can shift during development. We examined whether prenatal heteroplasmy measurements predict postnatal outcomes for the pathogenic...
Distinct mitochondrial-derived vesicle pathways connect mitochondria with peroxisomes and lysosomes [0.03%]
不同的线粒体衍生囊泡途径连接线粒体与过氧化物酶体和溶酶体
Ayumu Sugiura,Kohta Nakamura,Heidi M McBride et al.
Ayumu Sugiura et al.
Mitochondrial-derived vesicles (MDVs) mediate selective trafficking of mitochondrial proteins and lipids to other organelles and contribute to organelle communication and mitochondrial quality control. While MDVs that deliver mitochondrial ...