Yoshikazu Isomura
Yoshikazu Isomura
Optineurin knock-out forms TDP-43 aggregates to regulate TDP-43 protein levels despite autophagic up-regulation and aberrant TDP-43 expression [0.03%]
Optineurin敲除形成TDP-43聚集体，尽管自噬上调和TDP-43异常表达，仍可调节TDP-43蛋白水平
Yuta Maetani,Takashi Kurashige,Yui Tada et al.
Yuta Maetani et al.
Optineurin is a causative gene of amyotrophic lateral sclerosis (ALS) and has many roles in processes such as autophagy and inflammation. However, it is unclear how optineurin causes ALS. Optineurin knock-out (Optn-KO) mice, which have been...
Yasuhiro Go
Yasuhiro Go
In neuroscience research, the primary goal is to understand the complex morphological and anatomical structures of the brain and their physiological and behavioral functional relationships or to understand the causality of diseases that man...
Early postural adjustments in cats during a reaching task reflect strategies to predict the forthcoming target location [0.03%]
猫在伸展任务中早期的姿态调整反映预测即将到来目标位置的策略
Toshi Nakajima,Mirai Takahashi,Kaoru Takakusaki
Toshi Nakajima
Many types of voluntary movement depend on appropriate postural adjustments. In most situations, such postural adjustments are influenced by learning and are therefore subject to prediction strategies developed through learning. To address ...
The Parental Brain: Anatomization of 75 Years of Neuroscience 1951-2024 [0.03%]
父母大脑：神经科学75年解剖学研究 1951-2024
Alessandro Carollo,Lucrezia Torre,Marc H Bornstein et al.
Alessandro Carollo et al.
Studies of the parental brain have garnered significant attention, revealing neurobiological and psychological changes associated with caregiving. Here, we provide a comprehensive, data-driven overview of the scientific literature on the pa...
Neural coding: Foundational concepts, statistical formulations, and recent advances [0.03%]
神经编码：基础概念、统计方法及最新进展
Hideaki Shimazaki
Hideaki Shimazaki
Neural coding refers to the processes by which external stimuli are translated into neural activity and represented in a manner that drives behavior. Research in this field aims to elucidate these processes by identifying the neural activit...
Spinal nociceptive hypersensitivity induced by intramuscular capsaicin in rats subjected to multiple continuous stress [0.03%]
反复多次应激大鼠肌内注射辣椒素致脊髓痛觉过敏的实验研究
Rikuo Yamamoto,Koji Wakatsuki,Masaya Yasui et al.
Rikuo Yamamoto et al.
Persistent physical and psychological stress is highly relevant to the development of chronic muscle pain; however, the neural mechanisms underlying stress-induced hyperalgesia remain largely unknown. This study aimed to elucidate the perip...
Metformin alleviates auditory cell senescence by mitophagy induction [0.03%]
二甲双胍通过诱导线粒体自噬来缓解听觉细胞的衰老
Sung Il Cho,Eu-Ri Jo,Hee Sun Jang
Sung Il Cho
Age-related hearing loss is the most common type of hearing loss in older adults. However, its underlying cellular mechanism is still unclear. Impaired mitochondrial function is a hallmark of various age-related pathologies. To maintain mit...
Yoshikage Muroi,Toshiaki Ishii
Yoshikage Muroi
Animals exhibit a wide range of stress responses aimed at restoring homeostasis and promoting adaptation. In response to stress, they employ coping mechanisms to maintain physiological balance. Dysregulated stress-coping strategies have bee...
Bridge protein-mediated viral targeting of cells expressing endogenous μ-opioid G protein-coupled receptors in the mouse and monkey brain [0.03%]
桥接蛋白介导的病毒靶向表达内源性μ型阿片受体G蛋白偶联受体的小鼠和猴子脑细胞
Riki Kamaguchi,Satoko Amemori,Ken-Ichi Amemori et al.
Riki Kamaguchi et al.
Targeting specific cell types is essential for understanding their functional roles in the brain. Although genetic approaches enable cell-type-specific targeting in animals, their application to higher mammalian species, such as nonhuman pr...